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Research papers 2000-2019

2019

Y. Du, J.L. Guo, J. Wang, A.G. Mikos, and S. Zhang, “Hierarchically Designed Bone Scaffolds: From Internal Cues to External Stimuli,” Biomaterials, 218, 119334 (20pp) (2019).

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Y.S. Kim, J.L. Guo, J. Lam, K.J. Grande-Allen, P.S. Engel, and A.G. Mikos, “Synthesis of Injectable, Thermally Responsive, Chondroitin Sulfate-Cross-Linked Poly(N-Isopropylacrylamide) Hydrogels,” ACS Biomater. Sci. Eng., 5, 6405-6413 (2019).

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E.R. Molina, L.K. Chim, M.C. Salazar, S.M. Mehta, B.A. Menegaz, S.-E. Lamhamedi-Cherradi, T. Satish, S. Mohiuddin, D. McCall, A.M. Zaske, B. Cuglievan, A.J. Lazar, D.W. Scott, K.J. Grande-Allen, J.A. Ludwig, and A.G. Mikos, “Mechanically Tunable Coaxial Electrospun Models of YAP/TAZ Mechanoresponse and IGF-1R Activation in Osteosarcoma,” Acta Biomaterialia, 100, 38-51 (2019).

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P.D. Kontoyiannis, G.L. Koons, R.S. Hicklen, A.G. Mikos, and D.P. Kontoyiannis, “Insect Bite-Associated Invasive Fungal Infections,” Open Forum Infect. Dis., 6, ofz385 (4pp) (2019).

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J. Lu, X. Yan, X. Sun, X. Shen, H. Yin, C. Wang, Y. Liu, C. Lu, H. Fu, S. Yang, Y. Wang, X. Sun, L. Zhao, S. Lu, A.G. Mikos, J. Peng, and X. Wang, “Synergistic Effects of Dual-Presenting VEGF- and BDNF-Mimetic Peptide Epitopes from Self-Assembling Peptide Hydrogels on Peripheral Nerve Regeneration,” Nanoscale, 11, 19943-19958 (2019).

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G.L. Koons, K. Schenke-Layland, and A.G. Mikos, “Why, When, Who, What, How, and Where for Writing Literature Review Articles,” Ann. Biomed. Eng., 47, 2334-2340 (2019).

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J. Navarro, J. Swayambunathan, M.E. Janes, M. Santoro, A.G. Mikos, and J.P. Fisher, “Dual-Chambered Membrane Bioreactor for Coculture of Stratified Cell Populations,” Biotechnol. Bioeng., 116, 3253-3268 (2019).

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J.L. Guo, Y.S. Kim, and A.G. Mikos, “Biomacromolecules for Tissue Engineering: Emerging Biomimetic Strategies,” Biomacromolecules, 20, 2904-2912 (2019).

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L. Diaz-Gomez, P.D. Kontoyiannis, A.J. Melchiorri, and A.G. Mikos, “Three-Dimensional Printing of Tissue Engineering Scaffolds with Horizontal Pore and Composition Gradients,” Tissue Eng. Part C: Methods, 25, 411-420 (2019).

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A.M. Tatara, E. Watson, N.D. Albert, P.D. Kontoyiannis, D.P. Kontoyiannis, and A.G. Mikos, “A Murine Model of Cutaneous Aspergillosis for Evaluation of Biomaterials-based Local Delivery Therapies,” J. Biomed. Mater. Res. Part A, 107A, 1867-1874 (2019).

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I. Lodoso-Torrecilla, E.C. Grosfeld, A. Marra, B.T. Smith, A.G. Mikos, D.J.O. Ulrich, J.A. Jansen, and J.J.J.P. van den Beucken, “Multimodal Porogen Platforms for Calcium Phosphate Cement Degradation,” J. Biomed. Mater. Res. Part A, 107A, 1713-1722 (2019).

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J.L. Guo, Y.S. Kim, V.Y. Xie, B.T. Smith, E. Watson, J. Lam, H.A. Pearce, P.S. Engel, and A.G. Mikos, “Modular, Tissue-Specific, and Biodegradable Hydrogel Cross-Linkers for Tissue Engineering,” Science Adv., 5, eaaw7396 (11pp) (2019).

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M.M. Smoak, A. Han, E. Watson, A. Kishan, K.J. Grande-Allen, E. Cosgriff-Hernandez, and A.G. Mikos, “Fabrication and Characterization of Electrospun Decellularized Muscle-Derived Scaffolds,” Tissue Eng. Part C: Methods, 25, 276-287 (2019).

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S.M. Bittner, B.T. Smith, L. Diaz-Gomez, C.D. Hudgins, A.J. Melchiorri, D.W. Scott, J.P. Fisher, and A.G. Mikos, “Fabrication and Mechanical Characterization of 3D Printed Vertical Uniform and Gradient Scaffolds for Bone and Osteochondral Tissue Engineering,” Acta Biomaterialia, 90, 37-48 (2019).

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A.M. Tatara, G.L. Koons, E. Watson, T.C. Piepergerdes, S.R. Shah, B.T. Smith, J. Shum, J.C. Melville, I.A. Hanna, N. Demian, T. Ho, A. Ratcliffe, J.J.J.P. van den Beucken, J.A. Jansen, M.E. Wong, and A.G. Mikos, “Biomaterials-Aided Mandibular Reconstruction Using In Vivo Bioreactors,” Proceed. Natl. Acad. Sci. USA, 116, 6954-6963 (2019).

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M. Senturk, G. Lin, Z. Zuo, D. Mao, E. Watson, A.G. Mikos, and H.J. Bellen, “Ubiquilins Regulate Autophagic Flux through mTOR Signalling and Lysosomal Acidification,” Nature Cell Biol., 21, 384-396 (2019).

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M.M. Smoak, H.A. Pearce, and A.G. Mikos, “Microfluidic Devices for Disease Modeling in Muscle Tissue,” Biomaterials, 198, 250-258 (2019).

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Y.S. Kim, M.M. Smoak, A.J. Melchiorri, and A.G. Mikos, “An Overview of the Tissue Engineering Market in the United States from 2011 to 2018,” Tissue Eng. Part A, 25, 1-8 (2019).

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L. Diaz-Gomez, B.T. Smith, P.D. Kontoyiannis, S.M. Bittner, A.J. Melchiorri, and A.G. Mikos, “Multimaterial Segmented Fiber Printing for Gradient Tissue Engineering,” Tissue Eng. Part C: Methods, 25, 12-24 (2019).

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Y.S. Kim, M. Majid, A.J. Melchiorri, and A.G. Mikos, “Applications of Decellularized Extracellular Matrix in Bone and Cartilage Tissue Engineering,” Bioeng. Transl. Med., 4, 83-95 (2019).

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G.L. Koons and A.G. Mikos, “Progress in Three-Dimensional Printing with Growth Factors,” J. Controlled Release, 295, 50-59 (2019).

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2018

S.M. Bittner, J.L. Guo, and A.G. Mikos, “Spatiotemporal Control of Growth Factors in Three- Dimensional Printed Scaffolds,” Bioprinting, 11, e00032 (10pp) (2018).

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A.M. Tatara, S. Wurster, C.R. Lockworth, N.D. Albert, T.J. Walsh, A.G. Mikos, G.T. Eisenhoffer, and D.P. Kontoyiannis, “Immunosuppressed Adult Zebrafish Model of Mucormycosis,” Antimicrob. Agents Chemother., 62, e00698-18 (2018).

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E.J. Lee, T.M. Robinson, J.J. Tabor, A.G. Mikos, and J. Suh, “Reverse Transduction Can Improve Efficiency of AAV Vectors in Transduction-Resistant Cells,” Biotechnol. Bioeng., 115, 3042-3049 (2018).

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S.M. Bittner, J.L. Guo, A. Melchiorri, and A.G. Mikos, “Three-Dimensional Printing of Multilayered Tissue Engineering Scaffolds,” Materials Today, 21, 861-874 (2018).

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S. Wang, Z. Zhao, Y. Yang, A.G. Mikos, Z. Qiu, T. Song, F. Cui, X. Wang, and C. Zhang, “A High-Strength Mineralized Collagen Bone Scaffold for Large-Sized Cranial Bone Defect Repair in Sheep,” Regener. Biomater., 5, 283-292 (2018).

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M. Whitely, S. Cereceres, P. Dhavalikar, K. Salhadar, T. Wilems, B. Smith, A.G. Mikos, and E. Cosgriff-Hernandez, “Improved In Situ Seeding of 3D Printed Scaffolds Using Cell-Releasing Hydrogels,” Biomaterials, 185, 194-204 (2018).

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J. Lu, X. Shen, X. Sun, H. Yin, S. Yang, C. Lu, Y. Wang, Y. Liu, Y. Huang, Z. Yang, X. Dong, C. Wang, Q. Guo, L. Zhao, X. Sun, S. Lu, A.G. Mikos, J. Peng, and X. Wang, “Increased Recruitment of Endogenous Stem Cells and Chondrogenic Differentiation by a Composite Scaffold Containing Bone Marrow Homing Peptide for Cartilage Regeneration,” Theranostics, 8, 5039-5058 (2018).

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B.T. Smith, A. Lu, E. Watson, M. Santoro, A.J. Melchiorri, E.C. Grosfeld, J.J.J.P. van den Beucken, J.A. Jansen, D.W. Scott, J.P. Fisher, and A.G. Mikos, “Incorporation of Fast Dissolving Glucose Porogens and Poly(Lactic-co-Glycolic Acid) Microparticles within Calcium Phosphate Cements for Bone Tissue Regeneration,” Acta Biomaterialia, 78, 341-350 (2018).

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J. Lu, X. Sun, H. Yin, X. Shen, S. Yang, Y. Wang, W. Jiang, Y. Sun, L. Zhao, X. Sun, S. Lu, A.G. Mikos, J. Peng, and X. Wang, “A Neurotrophic Peptide-Functionalized Self-Assembling Peptide Nanofiber Hydrogel Enhances Rat Sciatic Nerve Regeneration,” Nano Res., 11, 4599-4613 (2018).

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B. Akar, A.M. Tatara, A. Sutradhar, H.-Y. Hsiao, M. Miller, M.-H. Cheng, A.G. Mikos, and E.M. Brey, “Large Animal Models of an In Vivo Bioreactor for Engineering Vascularized Bone,” Tissue Eng. Part B: Reviews, 24, 317-325 (2018).

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J. Yang, J.L. Guo, A.G. Mikos, C. He, and G. Cheng, “Material Processing and Design of Biodegradable Metal Matrix Composites for Biomedical Applications,” Ann. Biomed. Eng., 46, 1229-1240 (2018).

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A.M. Tatara, D.P. Kontoyiannis, and A.G. Mikos, “Drug Delivery and Tissue Engineering to Promote Wound Healing in the Immunocompromised Host: Current Challenges and Future Directions,” Adv. Drug Deliv. Rev., 129, 319-329 (2018).

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J. Zhou, X. Yang, W. Liu, C. Wang, Y. Shen, F. Zhang, H. Zhu, H. Sun, J. Chen, J. Lam, A.G. Mikos, and C. Wang, “Injectable OPF/Graphene Oxide Hydrogels Provide Mechanical Support and Enhance Cell Electrical Signaling after Implantation into Myocardial Infarct,” Theranostics, 8, 3317-3330 (2018).

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A.M. Tatara, A.J. Rozich, P.D. Kontoyiannis, E. Watson, N.D. Albert, G.R. Bennett, and A.G. Mikos, “Econazole-Releasing Porous Space Maintainers for Fungal Periprosthetic Joint Infection,” J. Mater. Sci. Mater. Med., 29, 70 (2018).

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L.K. Chim and A.G. Mikos, “Biomechanical Forces in Tissue Engineered Tumor Models,” Curr. Opin. Biomed. Eng., 6, 42-50 (2018).

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J.E. Trachtenberg, M. Santoro, C. Williams III, C.M. Piard, B.T. Smith, J.K. Placone, B.A. Menegaz, E.R. Molina, S.-E. Lamhamedi-Cherradi, J.A. Ludwig, V.I. Sikavitsas, J.P. Fisher, and A.G. Mikos, “Effects of Shear Stress Gradients on Ewing Sarcoma Cells Using 3D Printed Scaffolds and Flow Perfusion,” ACS Biomater. Sci. Eng., 4, 347-356 (2018).

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J. Yang, G.L. Koons, G. Cheng, L. Zhao, A.G. Mikos, and F. Cui, “A Review on the Exploitation of Biodegradable Magnesium-Based Composites for Medical Applications,” Biomed. Mater., 13, 022001 (8pp) (2018).

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I. Lodoso-Torrecilla, N.A.P. van Gestel, L.A. Díaz-Gómez, E.C. Grosfeld, K. Laperre, J.G.C. Wolke, B.T. Smith, J.J. Arts, A.G. Mikos, J.A. Jansen, S. Hofmann, and J.J.J.P. van den Beucken, “Multimodal Pore Formation in Calcium Phosphate Cements,” J. Biomed. Mater. Res. Part A, 106A, 500-509 (2018).

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2017

E. Watson, A.M. Tatara, D.P. Kontoyiannis, and A.G. Mikos, “Inherently Antimicrobial Biodegradable Polymers in Tissue Engineering,” ACS Biomater. Sci. Eng., 3, 1207-1220 (2017).

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S.T. Heo, A.M. Tatara, C. Jiménez-Ortigosa, Y. Jiang, R.E. Lewis, J. Tarrand, F. Tverdek, N.D. Albert, P.E. Verweij, J.F. Meis, A.G. Mikos, D.S. Perlin, and D.P. Kontoyiannis, “Changes in In Vitro Susceptibility Patterns of Aspergillus to Triazoles and Correlation with Aspergillosis Outcome in a Tertiary Care Cancer Center, 1999-2015,” Clin. Infect. Dis., 65, 216-225 (2017).

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E.J. Lee, B.K. Huh, S.N. Kim, J.Y. Lee, C.G. Park, A.G. Mikos, and Y.B. Choy, “Application of Materials as Medical Devices with Localized Drug Delivery Capabilities for Enhanced Wound Repair,” Progr. Mater. Sci., 89, 392-410 (2017).

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L.G. Bracaglia, B.T. Smith, E. Watson, N. Arumugasaamy, A.G. Mikos, and J.P. Fisher, “3D Printing for the Design and Fabrication of Polymer-Based Gradient Scaffolds,” Acta Biomaterialia, 56, 3-13 (2017).

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S. Wang, Y. Yang, Z. Zhao, X. Wang, A.G. Mikos, Z. Qiu, T. Song, X. Sun, L. Zhao, C. Zhang, and F. Cui, “Mineralized Collagen-Based Composite Bone Materials for Cranial Bone Regeneration in Developing Sheep,” ACS Biomater. Sci. Eng., 3, 1092-1099 (2017).

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A.M. Tatara, E. Watson, T. Satish, D.W. Scott, D.P. Kontoyiannis, P.S. Engel, and A.G. Mikos, “Synthesis and Characterization of Diol-Based Unsaturated Polyesters: Poly(Diol Fumarate) and Poly(Diol Fumarate-co-Succinate),” Biomacromolecules, 18, 1724-1735 (2017).

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Y. Du, H. Liu, Q. Yang, S. Wang, J. Wang, J. Ma, I. Noh, A.G. Mikos, and S. Zhang, “Selective Laser Sintering Scaffold with Hierarchical Architecture and Gradient Composition for Osteochondral Repair in Rabbits,” Biomaterials, 137, 37-48 (2017).

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T. Guo, T.R. Holzberg, C.G. Lim, F. Gao, A. Gargava, J.E. Trachtenberg, A.G. Mikos, and J.P. Fisher, “3D Printing PLGA: A Quantitative Examination of the Effects of Polymer Composition and Printing Parameters on Print Resolution,” Biofabrication, 9, 024101 (11pp) (2017).

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J.E. Trachtenberg, J.K. Placone, B.T. Smith, J.P. Fisher, and A.G. Mikos, “Extrusion-Based 3D Printing of Poly(Propylene Fumarate) Scaffolds with Hydroxyapatite Gradients,” J. Biomater. Sci., Polym. Ed., 28, 532-554 (2017).

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B.T. Smith, M. Santoro, E.C. Grosfeld, S.R. Shah, J.J.J.P. van den Beucken, J.A. Jansen, and A.G. Mikos, “Incorporation of Fast Dissolving Glucose Porogens into an Injectable Calcium Phosphate Cement for Bone Tissue Engineering,” Acta Biomaterialia, 50, 68-77 (2017).

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S.R. Shah, B.T. Smith, A.M. Tatara, E.R. Molina, E.J. Lee, T.C. Piepergerdes, B.A. Uhrig, R.E. Guldberg, G.N. Bennett, J.C. Wenke, and A.G. Mikos, “Effects of Local Antibiotic Delivery from Porous Space Maintainers on Infection Clearance and Induction of an Osteogenic Membrane in an Infected Bone Defect,” Tissue Eng. Part A, 23, 91-100 (2017).

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M. Santoro, B.A. Menegaz, S.E. Lamhamedi-Cherradi, E.R. Molina, D. Wu, W. Priebe, J.A. Ludwig, and A.G. Mikos, “Modeling Stroma-Induced Drug Resistance in a Tissue-Engineered Tumor Model of Ewing Sarcoma,” Tissue Eng. Part A, 23, 80-89 (2017).

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T.N. Vo, A.M. Tatara, M. Santoro, J.J.J.P. van den Beucken, S.C.G. Leeuwenburgh, J.A. Jansen, and A.G. Mikos, “Acellular Mineral Deposition within Injectable, Dual-Gelling Hydrogels for Bone Tissue Engineering,” J. Biomed. Mater. Res. Part A, 105A, 110-117 (2017).

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2016

S.I. Simon, A.G. Mikos, and L.V. McIntire, “Fond Memories of our Mentor J. David Hellums, Annals of Biomedical Engineering,” Ann. Biomed. Eng., 44, 3157 (2016).

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M. Santoro, S.R. Shah, J.L. Walker, and A.G. Mikos, “Poly(Lactic Acid) Nanofibrous Scaffolds for Tissue Engineering,” Adv. Drug Deliv. Rev., 107, 206-212 (2016).

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A.M. Tatara, S.R. Shah, N. Demian, T. Ho, J. Shum, J.J.J.P. van den Beucken, J.A. Jansen, M.E. Wong, and A.G. Mikos, “Reconstruction of Large Mandibular Defects Using Autologous Tissues Generated from In Vivo Bioreactors,” Acta Biomaterialia, 45, 72-84 (2016).

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J.E. Trachtenberg, J.K. Placone, B.T. Smith, C.M. Piard, M. Santoro, D.W. Scott, J.P. Fisher, and A.G. Mikos, “Extrusion-Based 3D Printing of Poly(Propylene Fumarate) in a Full-Factorial Design,” ACS Biomater. Sci. Eng., 2, 1771-1780 (2016).

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S.-E. Lamhamedi-Cherradi, B.A. Menegaz, V. Ramamoorthy, D. Vishwamitra, Y. Wang, R.L. Maywald, A.S. Buford, I. Fokt, S. Skora, J. Wang, A. Naing, A.J. Lazar, E.M. Rohren, N.C. Daw, V. Subbiah, R.S. Benjamin, R. Ratan, W. Priebe, A.G. Mikos, H.M. Amin, and J.A. Ludwig, “IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma,” J. Natl. Cancer Inst., 108, djw182 (2016).

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S.R. Shah, S. Young, J.L. Goldman, J.A. Jansen, M.E. Wong, and A.G. Mikos, “A Composite Critical-Size Rabbit Mandibular Defect for Evaluation of Craniofacial Tissue Regeneration,” Nature Protocols, 11, 1989-2009 (2016).

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A.M. Tatara and A.G. Mikos, “Tissue Engineering in Orthopaedics,” J. Bone Joint Surg., 98, 1132-1139 (2016).

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A.M. Tatara, A.G. Mikos, and D.P. Kontoyiannis, “Factors Affecting Patient Outcome in Primary Cutaneous Aspergillosis,” Medicine, 95, e3747 (2016).

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T.N. Vo, Y. Tabata, and A.G. Mikos, “Effects of Cellular Parameters on the In Vitro Osteogenic Potential of Dual-Gelling Mesenchymal Stem Cell-Laden Hydrogels,” J. Biomater. Sci., Polym. Ed., 27, 1277-1290 (2016).

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S. Lu, E.J. Lee, J. Lam, Y. Tabata, and A.G. Mikos, “Evaluation of Gelatin Microparticles as Adherent-Substrates for Mesenchymal Stem Cells in a Hydrogel Composite,” Ann. Biomed. Eng., 44, 1894-1907 (2016).

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S.R. Shah, A.M. Tatara, J. Lam, S. Lu, D.W. Scott, G.N. Bennett, J.J.J.P. van den Beucken, J.A. Jansen, M.E. Wong, and A.G. Mikos, “Polymer-Based Local Antibiotic Delivery for Prevention of Polymicrobial Infection in Contaminated Mandibular Implants,” ACS Biomater. Sci. Eng., 2, 558-566 (2016).

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J. Lam, E.C. Clark, E.L.S. Fong, E.J. Lee, S. Lu, Y. Tabata, and A.G. Mikos, “Data Describing the Swelling Behavior and Cytocompatibility of Biodegradable Polyelectrolyte Hydrogels Incorporating Poly(L-Lysine) for Applications in Cartilage Tissue Engineering,” Data-in-Brief, 7, 614-619 (2016).

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J. Lam, E.C. Clark, E.L.S. Fong, E.J. Lee, S. Lu, Y. Tabata, and A.G. Mikos, “Evaluation of Cell-Laden Polyelectrolyte Hydrogels Incorporating Poly(L-Lysine) for Applications in Cartilage Tissue Engineering,” Biomaterials, 83, 332-346 (2016).

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T.N. Vo, S.R. Shah, S. Lu, A.M. Tatara, E.J. Lee, T.T. Roh, Y. Tabata, and A.G. Mikos, “Injectable Dual-Gelling Cell-Laden Composite Hydrogels for Bone Tissue Engineering,” Biomaterials, 83, 1-11 (2016).

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A.M. Tatara and A.G. Mikos, “2015 Lifetime Achievement Award of Tissue Engineering and Regenerative Medicine International Society-Americas: Antonios G. Mikos, PhD,” Tissue Eng. Part A, 22, 1-2 (2016).

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P.M. Mountziaris, S.R. Shah, J. Lam, G.N. Bennett, and A.G. Mikos, “A Rapid, Flexible Method for Incorporating Controlled Antibiotic Release into Porous Polymethylmethacrylate Space Maintainers for Craniofacial Reconstruction,” Biomater. Sci., 4, 121-129 (2016).

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E.L.S. Fong, X. Wan, J. Yang, M. Morgado, A.G. Mikos, D.A. Harrington, N.M. Navone, and M.C. Farach-Carson, “A 3D In Vitro Model of Patient-Derived Prostate Cancer Xenograft for Controlled Interrogation of In Vivo Tumor-Stromal Interactions,” Biomaterials, 77, 164-172 (2016).

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2015

B.T. Smith, J. Shum, M.E. Wong, A.G. Mikos, and S. Young, “Bone Tissue Engineering Challenges in Oral and Maxillofacial Surgery,” Adv. Exp. Med. Biol., 881, 57-78 (2015).

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S. Lu, J. Lam, J.E. Trachtenberg, E.J. Lee, H. Seyednejad, J.J.J.P. van den Beucken, Y. Tabata, F.K. Kasper, D.W. Scott, M.E. Wong, J.A. Jansen, and A.G. Mikos, “Correlation between the Repair of Cartilage and Subchondral Bone in an Osteochondral Defect Using Bilayered, Biodegradable Hydrogel Composites,” Tissue Eng. Part C: Methods, 21, 1216-1225 (2015).

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E.R. Molina, B.T. Smith, S.R. Shah, H. Shin, and A.G. Mikos, “Immunomodulatory Properties of Stem Cells and Bioactive Molecules for Tissue Engineering,” J. Controlled Release, 219, 107-118 (2015).

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B.M. Watson, T.N. Vo, P.S. Engel, and A.G. Mikos, “Biodegradable, In Situ-Forming Cell-Laden Hydrogel Composites of Hydroxyapatite Nanoparticles for Bone Regeneration,” Ind. Eng. Chem. Res., 54, 10206-10211 (2015).

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A.G. Mikos, P.C. Johnson, J.P. Fisher, and J.A. Jansen, “The Maturation of Tissue Engineering,” Tissue Eng. Part A, 21, 2473-2475 (2015).

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B.N. Sathy, B.M. Watson, L.A. Kinard, P.P. Spicer, R.L. Dahlin, A.G. Mikos, and S. Nair, “Bone Tissue Engineering with Multilayered Scaffolds – Part II: Combining Vascularization with Bone Formation in Critical-Sized Bone Defect,” Tissue Eng. Part A, 21, 2495-2503 (2015).

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B.N. Sathy, U. Mony, D. Menon, V.K. Baskaran, A.G. Mikos, and S. Nair, “Bone Tissue Engineering with Multilayered Scaffolds – Part I: An Approach for Vascularizing Engineered Constructs In Vivo,” Tissue Eng. Part A, 21, 2480-2494 (2015).

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S.K. Madhurakkat Perikamana, J. Lee, Y.B. Lee, Y.M. Shin, E.J. Lee, A.G. Mikos, and H. Shin, “Materials from Mussel-Inspired Chemistry for Cell and Tissue Engineering Applications,” Biomacromolecules, 16, 2541-2555 (2015).

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M. Santoro, S.E. Lamhamedi-Cherradi, B.A. Menegaz, J.A. Ludwig, and A.G. Mikos, “Flow Perfusion Effects on Three-Dimensional Culture and Drug Sensitivity of Ewing Sarcoma,” Proceed. Natl. Acad. Sci. USA, 112, 10304-10309 (2015).

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A.M. Tatara, S.R. Shah, C.E. Livingston, and A.G. Mikos, “Infected Animal Models for Tissue Engineering,” Methods, 84, 17-24 (2015).

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B.M. Watson, T.N. Vo, A.M. Tatara, S.R. Shah, D.W. Scott, P.S. Engel, and A.G. Mikos, “Biodegradable, Phosphate-Containing, Dual-Gelling Macromers for Cellular Delivery in Bone Tissue Engineering,” Biomaterials, 67, 286-296 (2015).

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J. Lam, S. Lu, F.K. Kasper, and A.G. Mikos, “Strategies for Controlled Delivery of Biologics for Cartilage Repair,” Adv. Drug Deliv. Rev., 84, 123-134 (2015).

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A.M. Tatara, S.R. Shah, M. Sotoudeh, A.M. Henslee, M.E. Wong, A. Ratcliffe, F.K. Kasper, and A.G. Mikos, “Effects of Electron Beam Sterilization on Mechanical Properties of a Porous Polymethylmethacrylate Space Maintenance Device,” J. Med. Dev., 9, 024501-1-024501-4 (2015).

[Abstract] [HTML] [PDF]

A.M. Tatara, J.D. Kretlow, P.P. Spicer, S. Lu, J. Lam, W. Liu, Y. Cao, G. Liu, J.D. Jackson, J.J. Yoo, A. Atala, J.J.J.P. van den Beucken, J.A. Jansen, F.K. Kasper, T. Ho, N. Demian, M.J. Miller, M.E. Wong, and A.G. Mikos, “Autologously Generated Tissue-Engineered Bone Flaps for Reconstruction of Large Mandibular Defects in an Ovine Model,” Tissue Eng. Part A, 21, 1520-1528 (2015).

[Abstract] [HTML] [PDF]

T.N. Vo, A.K. Ekenseair, P.P. Spicer, B.M. Watson, S.N. Tzouanas, T.T. Roh, and A.G. Mikos, “In Vitro and In Vivo Evaluation of Self-Mineralization and Biocompatibility of Injectable, Dual-Gelling Hydrogels for Bone Tissue Engineering,” J. Controlled Release, 205, 25-34 (2015).

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A.M. Henslee, D.M. Yoon, B.Y. Lu, J. Yu, A.A. Arango, L.P. Marruffo, L. Seng, T.D. Anver, H. Ather, M.B. Nair, S.O. Piper, N. Demian, M.E.K. Wong, F.K. Kasper, and A.G. Mikos, “Characterization of an Injectable, Degradable Polymer for Mechanical Stabilization of Mandibular Fractures,” J. Biomed. Mater. Res. Part B: Appl. Biomater., 103B, 529-538 (2015).

[Abstract] [HTML] [PDF]

J.E. Trachtenberg, T.N. Vo, and A.G. Mikos, “Pre-Clinical Characterization of Tissue Engineering Constructs for Bone and Cartilage Regeneration,” Ann. Biomed. Eng., 43, 681-696 (2015).

[Abstract] [HTML] [PDF]

S.R. Shah, C.A. Werlang, F.K. Kasper, and A.G. Mikos, “Novel Applications of Statins for Bone Regeneration,” Natl. Sci. Rev., 2, 85-99 (2015).

[Abstract] [HTML] [PDF]

L. Wang, S. Lu, J. Lam, F.K. Kasper, and A.G. Mikos, “Fabrication of Cell-Laden Macroporous Biodegradable Hydrogels with Tunable Porosities and Pore Sizes,” Tissue Eng. Part C: Methods, 21, 263-273 (2015).

[Abstract] [HTML] [PDF]

A.M. Henslee, S.R. Shah, M.E. Wong, A.G. Mikos, and F.K. Kasper, “Degradable, Antibiotic Releasing Poly(Propylene Fumarate)-Based Constructs for Craniofacial Space Maintenance Applications,” J. Biomed. Mater. Res. Part A, 103A, 1485-1497 (2015).

[Abstract] [HTML] [PDF]

2014

K.M. Hubka, R.L. Dahlin, V.V. Meretoja, F.K. Kasper, and A.G. Mikos, “Enhancing Chondrogenic Phenotype for Cartilage Tissue Engineering: Monoculture and Coculture of Articular Chondrocytes and Mesenchymal Stem Cells,” Tissue Eng. Part B: Reviews, 20, 641-654 (2014).

[Abstract] [HTML] [PDF]

S.-E. Lamhamedi-Cherradi, M. Santoro, V. Ramammoorthy, B.A. Menegaz, G. Bartholomeusz, L.R. Iles, H.M. Amin, A.J. Livingston, A.G. Mikos, and J.A. Ludwig, “3D Tissue-Engineered Model of Ewing’s Sarcoma,” Adv. Drug Deliv. Rev., 79-80, 155-171 (2014).

[Abstract] [HTML] [PDF]

A.M. Tatara, M.E. Wong, and A.G. Mikos, “In Vivo Bioreactors for Mandibular Reconstruction,” J. Dent. Res., 93, 1196-1202 (2014).

[Abstract] [HTML] [PDF]

R.L. Dahlin, V.V. Meretoja, M. Ni, F.K. Kasper, and A.G. Mikos, “Chondrogenic Phenotype of Articular Chondrocytes in Monoculture and Co-Culture with Mesenchymal Stem Cells in Flow Perfusion,” Tissue Eng. Part A, 20, 2883-2891 (2014).

[Abstract] [HTML] [PDF]

S.R. Shah, A.M. Henslee, P.P. Spicer, S. Yokota, S. Petrichenko, S. Allahabadi, G.N. Bennett, M.E. Wong, F.K. Kasper, and A.G. Mikos, “Effects of Antibiotic Physicochemical Properties on their Release Kinetics from Biodegradable Polymer Microparticles,” Pharm. Res., 31, 3379-3389 (2014).

[Abstract] [HTML] [PDF]

A.W.G. Nijhuis, S. Takemoto, M.R. Nejadnik, Y. Li, X. Yang, D.A. Ossipov, J. Hilborn, A.G. Mikos, M. Yoshinari, J.A. Jansen, and S.C.G. Leeuwenburgh, “Rapid Screening of Mineralization Capacity of Biomaterials by Means of Quantification of Enzymatically Deposited Calcium Phosphate,” Tissue Eng. Part C: Methods, 20, 838-850 (2014).

[Abstract] [HTML] [PDF]

J.E. Trachtenberg, P.M. Mountziaris, J.S. Miller, M. Wettergreen, F.K. Kasper, and A.G. Mikos, “Open-Source Three-Dimensional Printing of Biodegradable Polymer Scaffolds for Tissue Engineering,” J. Biomed. Mater. Res. Part A, 102A, 4326-4335 (2014).

[Abstract] [HTML] [PDF]

L.A. Kinard, R.L. Dahlin, J. Lam, S. Lu, E.J. Lee, F.K. Kasper, and A.G. Mikos, “Synthetic Biodegradable Hydrogel Delivery of Demineralized Bone Matrix for Bone Augmentation in a Rat Model,” Acta Biomaterialia, 10, 4574-4582 (2014).

[Abstract] [HTML] [PDF]

C.J. Needham, S.R. Shah, R.L. Dahlin, L.A. Kinard, J. Lam, B.M. Watson, S. Lu, F.K. Kasper, and A.G. Mikos, “Osteochondral Tissue Regeneration Through Polymeric Delivery of DNA Encoding for the SOX Trio and RUNX2,” Acta Biomaterialia, 10, 4103-4112 (2014).

[Abstract] [HTML] [PDF]

S. Lu, J. Lam, J.E. Trachtenberg, E.J. Lee, H. Seyednejad, J.J.J.P. van den Beucken, Y. Tabata, M.E. Wong, J.A. Jansen, A.G. Mikos, and F.K. Kasper, “Dual Growth Factor Delivery from Bilayered, Biodegradable Hydrogel Composites for Spatially-Guided Osteochondral Tissue Repair,” Biomaterials, 35, 8829-8839 (2014).

[Abstract] [HTML] [PDF]

J. Lam, S. Lu, E.J. Lee, J.E. Trachtenberg, V.V. Meretoja, R.L. Dahlin, J.J.J.P. van den Beucken, Y. Tabata, M.E. Wong, J.A. Jansen, A.G. Mikos, and F.K. Kasper, “Osteochondral Defect Repair Using Bilayered Hydrogels Encapsulating Both Chondrogenically and Osteogenically Pre-Differentiated Mesenchymal Stem Cells in a Rabbit Model,” Osteoarthritis Cartilage, 22, 1291-1300 (2014).

[Abstract] [HTML] [PDF]

J. Lam, K. Kim, S. Lu, Y. Tabata, D.W. Scott, A.G. Mikos, and F.K. Kasper, “A Factorial Analysis of the Combined Effects of Hydrogel Fabrication Parameters on the In Vitro Swelling and Degradation of Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels,” J. Biomed. Mater. Res. Part A, 102A, 3477-3487 (2014).

[Abstract] [HTML] [PDF]

M. Santoro, A.M. Tatara, and A.G. Mikos, “Gelatin Carriers for Drug and Cell Delivery in Tissue Engineering,” J. Controlled Release, 190, 210-218 (2014).

[Abstract] [HTML] [PDF]

E.L.S. Fong, M. Martinez, J. Yang, A.G. Mikos, N.M. Navone, D.A. Harrington, and M.C. Farach-Carson, “Hydrogel-Based 3D Model of Patient-Derived Prostate Xenograft Tumors Suitable for Drug Screening,” Mol. Pharm., 11, 2040-2050 (2014).

[Abstract] [HTML] [PDF]

R.L. Dahlin, J.G. Gershovich, F.K. Kasper, and A.G. Mikos, “Flow Perfusion Co-Culture of Human Mesenchymal Stem Cells and Endothelial Cells on Biodegradable Polymer Scaffolds,” Ann. Biomed. Eng., 42, 1381-1390 (2014).

[Abstract] [HTML] [PDF]

R.L. Dahlin, L.A. Kinard, J. Lam, C.J. Needham, S. Lu, F.K. Kasper, and A.G. Mikos, “Articular Chondrocytes and Mesenchymal Stem Cells Seeded on Biodegradable Scaffolds for the Repair of Cartilage in a Rat Osteochondral Defect Model,” Biomaterials, 35, 7460-7469 (2014).

[Abstract] [HTML] [PDF]

B.M. Watson, F.K. Kasper, P.S. Engel, and A.G. Mikos, “Synthesis and Characterization of Injectable, Biodegradable, Phosphate-Containing, Chemically Cross-Linkable, Thermoresponsive Macromers for Bone Tissue Engineering,” Biomacromolecules, 15, 1788-1796 (2014).

[Abstract] [HTML] [PDF]

L.A. Kinard, R.L. Dahlin, A.M. Henslee, P.P. Spicer, C.-Y. Chu, Y. Tabata, J.J.J.P. van den Beucken, J.A. Jansen, S. Young, M.E. Wong, F.K. Kasper, and A.G. Mikos, “Tissue Response to Composite Hydrogels for Vertical Bone Augmentation in the Rat,” J. Biomed. Mater. Res. Part A, 102A, 2079-2088 (2014).

[Abstract] [HTML] [PDF]

V.V. Meretoja, R.L. Dahlin, S. Wright, F.K. Kasper, and A.G. Mikos, “Articular Chondrocyte Redifferentiation in 3D Co-Cultures with Mesenchymal Stem Cells,” Tissue Eng. Part C: Methods, 20, 514-523 (2014).

[Abstract] [HTML] [PDF]

T.N. Vo, J.E. Trachtenberg, and A.G. Mikos, “In Vitro Techniques for Biomaterial Evaluation in Bone and Cartilage Tissue Engineering,” Regener. Med., J. Japan. Soc. Regener. Med., 13, 125-149 (2014).

 

A.M. Henslee, P.P. Spicer, S.R. Shah, A.M. Tatara, F.K. Kasper, A.G. Mikos, and M.E. Wong, “Use of Porous Space Maintainers in Staged Mandibular Reconstruction,” Oral Maxillofac. Surg. Clin. North Am., 26, 143-149 (2014).

[Abstract] [HTML] [PDF]

E.J. Levorson, P.M. Mountziaris, O. Hu, F.K. Kasper, and A.G. Mikos, “Cell-Derived Polymer/Extracellular Matrix Composite Scaffolds for Cartilage Regeneration, Part 1: Investigation of Cocultures and Seeding Densities for Improved Extracellular Matrix Deposition,” Tissue Eng. Part C: Methods, 20, 340-357 (2014).

[Abstract] [HTML] [PDF]

E.J. Levorson, O. Hu, P.M. Mountziaris, F.K. Kasper, and A.G. Mikos, “Cell-Derived Polymer/Extracellular Matrix Composite Scaffolds for Cartilage Regeneration, Part 2: Construct Devitalization and Determination of Chondroinductive Capacity,” Tissue Eng. Part C: Methods, 20, 358-372 (2014).

[Abstract] [HTML] [PDF]

E.J. Levorson, M. Santoro, F.K. Kasper, and A.G. Mikos, “Direct and Indirect Co-Culture of Chondrocytes and Mesenchymal Stem Cells for the Generation of Polymer/Extracellular Matrix Hybrid Constructs,” Acta Biomaterialia, 10, 1824-1835 (2014).

[Abstract] [HTML] [PDF]

S.N. Tzouanas, A.K. Ekenseair, F.K. Kasper, and A.G. Mikos, “Mesenchymal Stem Cell and Gelatin Microparticle Encapsulation in Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineering,” J. Biomed. Mater. Res. Part A, 102A, 1222-1230 (2014).

[Abstract] [HTML] [PDF]

B.M. Watson, F.K. Kasper, and A.G. Mikos, “Phosphorous-Containing Polymers for Regenerative Medicine,” Biomed. Mater., 9, 025014 (10pp) (2014).

[Abstract] [HTML] [PDF]

E.J. Lee, F.K. Kasper, and A.G. Mikos, “Biomaterials for Tissue Engineering,” Ann. Biomed. Eng., 42, 323-337 (2014).

[Abstract] [HTML] [PDF]

J. Ma, F. Yang, S.K. Both, M. Kersten-Niessen, M. Bongio, J. Pan, F.-Z. Cui, F.K. Kasper, A.G. Mikos, J.A. Jansen, and J.J.J.P. van den Beucken, “Comparison of Cell-Loading Methods in Hydrogel Systems,” J. Biomed. Mater. Res. Part A, 102A, 935-946 (2014).

[Abstract] [HTML] [PDF]

E.J. Lee, J.J. Tabor, and A.G. Mikos, “Leveraging Synthetic Biology for Tissue Engineering Applications,” Inflamm. Regener., 34, 15-22 (2014).

[Abstract] [HTML] [PDF]

J. Lam, S. Lu, Y. Tabata, A.G. Mikos, and F.K. Kasper, “Generation of Osteochondral Tissue Constructs with Chondrogenically and Osteogenically Pre-differentiated Mesenchymal Stem Cells Encapsulated in Bilayered Hydrogels,” Acta Biomaterialia, 10, 1112-1123 (2014).

[Abstract] [HTML] [PDF]

T.N. Vo, A.K. Ekenseair, F.K. Kasper, and A.G. Mikos, “Synthesis, Physicochemical Characterization, and Cytocompatibility of Bioresorbable, Dual-Gelling Injectable Hydrogels,” Biomacromolecules, 15, 132-142 (2014).

[Abstract] [HTML] [PDF]

E.L. Fong, M. Santoro, M.C. Farach-Carson, F.K. Kasper, and A.G. Mikos, “Tissue Engineering Perfusable Cancer Models,” Curr. Opin. Chem. Eng., 3, 112-117 (2014).

[Abstract] [HTML] [PDF]

C.G. Ambrose, T.A. Clyburn, J. Mika, G.R. Gogola, H.B. Kaplan, A. Wanger, and A.G. Mikos, “Evaluation of Antibiotic-Impregnated Microspheres for the Prevention of Implant-Associated Orthopaedic Infections,” J. Bone Joint Surg., 96, 128-134 (2014).

[Abstract] [HTML] [PDF]

C.J. Needham, S.R. Shah, P.M. Mountziaris, F.K. Kasper, and A.G. Mikos, “Modulation of Polyplex Release from Biodegradable Microparticles through Poly(Ethylenimine) Modification and Varying Loading Concentration,” Pharm. Res., 31, 77-85 (2014).

[Abstract] [HTML] [PDF]

R.L. Dahlin, M. Ni, V.V. Meretoja, F.K. Kasper, and A.G. Mikos, “TGF-ß3-Induced Chondrogenesis in Co-Cultures of Chondrocytes and Mesenchymal Stem Cells on Biodegradable Scaffolds,” Biomaterials, 35, 123-132 (2014).

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2013

S.R. Shah, F.K. Kasper, and A.G. Mikos, “Perspectives on the Prevention and Treatment of Infection for Orthopedic Tissue Engineering Applications,” Chin. Sci. Bull., 58, 4342-4348 (2013).

[Abstract] [HTML] [PDF]

J.G. Gershovich, R.L. Dahlin, F.K. Kasper, and A.G. Mikos, “Enhanced Osteogenesis in Cocultures with Human Mesenchymal Stem Cells and Endothelial Cells on Polymeric Microfiber Scaffolds,” Tissue Eng. Part A, 19, 2565-2576 (2013).

[Abstract] [HTML] [PDF]

M.R. Nejadnik, X. Yang, T. Mimura, Z. Tahmasebi Birgani, P. Habibovic, K. Itatani, J.A. Jansen, J. Hilborn, D.A. Ossipov, A.G. Mikos, and S.C.G. Leeuwenburgh, “Calcium-Mediated Secondary Cross-Linking of Bisphosphonated Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels,” Macromol. Biosci., 13, 1308-1313 (2013).

[Abstract] [HTML] [PDF]

E.J. Rivera, L.A. Tran, M. Hernandez-Rivera, D. Yoon, A.G. Mikos, I.A. Rusakova, B.Y. Cheong, M.G. Cabreira-Hansen, J.T. Willerson, E.C. Perin, and L.J. Wilson, “Bismuth@US-Tubes as a Potential Contrast Agent for X-Ray Imaging Applications,” J. Mater. Chem. B, 1, 4792-4800 (2013).

[Abstract] [HTML] [PDF]

J.E. Trachtenberg, P.M. Mountziaris, F.K. Kasper, and A.G. Mikos, “Fiber-Based Composite Tissue Engineering Scaffolds for Drug Delivery,” Israel J. Chem., 53, 646-654 (2013).

[Abstract] [HTML] [PDF]

P.P. Spicer, S.R. Shah, A.M. Henslee, B.M. Watson, L.A. Kinard, J.D. Kretlow, K. Bevil, L. Kattchee, G.N. Bennett, N. Demian, K. Mende, C.K. Murray, J.A. Jansen, M.E. Wong, A.G. Mikos, and F.K. Kasper, “Evaluation of Antibiotic Releasing Porous Polymethylmethacrylate Space Maintainers in an Infected Composite Tissue Defect Model,” Acta Biomaterialia, 9, 8832-8839 (2013).

[Abstract] [HTML] [PDF]

M. Bongio, M.R. Nejadnik, F.K. Kasper, A.G. Mikos, J.A. Jansen, S.C.G. Leeuwenburgh, and J.J.J.P. van den Beucken, “Development of an In Vitro Confinement Test to Predict the Clinical Handling of Polymer-Based Injectable Bone Substitutes,” Polym. Test., 32, 1379-1384 (2013).

[Abstract] [HTML] [PDF]

P.M. Mountziaris, E.D. Lehman, I. Mountziaris, D.C. Sing, F.K. Kasper, and A.G. Mikos, “Effect of Temporally Patterned TNF-a Delivery on In Vitro Osteogenic Differentiation of Mesenchymal Stem Cells Cultured on Biodegradable Polymer Scaffolds,” J. Biomater. Sci., Polym. Ed., 24, 1794-1813 (2013).

[Abstract] [HTML] [PDF]

L.A. Kinard, C.-Y. Chu, Y. Tabata, F.K. Kasper, and A.G. Mikos, “Bone Morphogenetic Protein-2 Release from Composite Hydrogels of Oligo(Poly(Ethylene Glycol) Fumarate) and Gelatin,” Pharm. Res., 30, 2332-2343 (2013).

[Abstract] [HTML] [PDF]

G. Lalwani, A.M. Henslee, B. Farshid, P. Parmar, L. Lin, Y.-X. Qin, F.K. Kasper, A.G. Mikos, and B. Sitharaman, “Tungsten Disulfide Nanotubes Reinforced Biodegradable Polymers for Bone Tissue Engineering,” Acta Biomaterialia, 9, 8365-8373 (2013).

[Abstract] [HTML] [PDF]

R.L. Dahlin, V.V. Meretoja, M. Ni, F.K. Kasper, and A.G. Mikos, “Hypoxia and Flow Perfusion Modulate Proliferation and Gene Expression of Articular Chondrocytes on Porous Scaffolds,” AIChE J., 59, 3158-3166 (2013).

[Abstract] [HTML] [PDF]

C.T. Lim, X. Ren, M.H. Afizah, S. Tarigan-Panjaitan, Z. Yang, Y. Wu, K.S. Chian, A.G. Mikos, and J.H. Hui, “Repair of Osteochondral Defects with Rehydrated Freeze-Dried Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels Seeded with Bone Marrow Mesenchymal Stem Cells in a Porcine Model,” Tissue Eng. Part A, 19, 1852-1861 (2013).

[Abstract] [HTML] [PDF]

S.R. Shah, A.M. Tatara, R.N. D’Souza, A.G. Mikos, and F.K. Kasper, “Evolving Strategies for Preventing Biofilm on Implantable Materials,” Materials Today, 16, 177-182 (2013).

[Abstract] [HTML] [PDF]

M. Bongio, M.R. Nejadnik, Z.T. Birgani, P. Habibovic, L.A. Kinard, F.K. Kasper, A.G. Mikos, J.A. Jansen, S.C.G. Leeuwenburgh, and J.J.J.P. van den Beucken, “In Vitro and In Vivo Enzyme-Mediated Biomineralization of Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels,” Macromol. Biosci., 13, 777-788 (2013).

[Abstract] [HTML] [PDF]

J.H. Hui, X. Ren, M.H. Afizah, K.S. Chian, and A.G. Mikos, “Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogel Enhances Osteochondral Repair in Porcine Femoral Condyle Defects,” Clin. Orthop. Rel. Res., 471, 1174-1185 (2013).

[Abstract] [HTML] [PDF]

L. Wang, D.M. Yoon, P.P. Spicer, A.M. Henslee, D.W. Scott, M.E. Wong, F.K. Kasper, and A.G. Mikos, “Characterization of Porous Polymethylmethacrylate Space Maintainers for Craniofacial Reconstruction,” J. Biomed. Mater. Res. Part B: Appl. Biomater., 101B, 813-825 (2013).

[Abstract] [HTML] [PDF]

E.L.S. Fong, S.-E. Lamhamedi-Cherradi, E. Burdett, V. Ramamoorthy, A.J. Lazar, F.K. Kasper, M.C. Farach-Carson, D. Vishwamitra, E.G. Demicco, B.A. Menegaz, H.M. Amin, A.G. Mikos, and J.A. Ludwig, “Modeling Ewing Sarcoma Tumors In Vitro with 3D Scaffolds,” Proceed. Natl. Acad. Sci. USA, 110, 6500-6505 (2013).

[Abstract] [HTML] [PDF]

K. Kim, J. Lam, S. Lu, P.P. Spicer, A. Lueckgen, Y. Tabata, M.E. Wong, J.A. Jansen, A.G. Mikos, and F.K. Kasper, “Osteochondral Tissue Regeneration Using a Bilayered Composite Hydrogel with Modulating Dual Growth Factor Release Kinetics in a Rabbit Model,” J. Controlled Release, 168, 166-178 (2013).

[Abstract] [HTML] [PDF]

G. Lalwani, A.M. Henslee, B. Farshid, L. Lin, F.K. Kasper, Y.-X. Qin, A.G. Mikos, and B. Sitharaman, “Two-Dimensional Nanostructure-Reinforced Biodegradable Polymeric Nanocomposites for Bone Tissue Engineering,” Biomacromolecules, 14, 900-909 (2013).

[Abstract] [HTML] [PDF]

R.A. Thibault, A.G. Mikos, and F.K. Kasper, “Osteogenic Differentiation of Mesenchymal Stem Cells on Demineralized and Devitalized Biodegradable Polymer and Extracellular Matrix Hybrid Constructs,” J. Biomed. Mater. Res. Part A, 101A, 1225-1236 (2013).

[Abstract] [HTML] [PDF]

V.V. Meretoja, R.L. Dahlin, S. Wright, F.K. Kasper, and A.G. Mikos, “The Effect of Hypoxia on the Chondrogenic Differentiation of Co-Cultured Articular Chondrocytes and Mesenchymal Stem Cells in Scaffolds,” Biomaterials, 34, 4266-4273 (2013).

[Abstract] [HTML] [PDF]

A.K. Ekenseair, F.K. Kasper, and A.G. Mikos, “Perspectives on the Interface of Drug Delivery and Tissue Engineering,” Adv. Drug Deliv. Rev., 65, 89-92 (2013).

[Abstract] [HTML] [PDF]

M. Bongio, J.J.J.P. van den Beucken, M.R. Nejadnik, Z.T. Birgani, P. Habibovic, L.A. Kinard, F.K. Kasper, A.G. Mikos, S.C.G. Leeuwenburgh, and J.A. Jansen, “Subcutaneous Tissue Response and Osteogenic Performance of Calcium Phosphate Nanoparticle-Enriched Hydrogels in the Tibial Medullary Cavity of Guinea Pigs,” Acta Biomaterialia, 9, 5464-5474 (2013).

[Abstract] [HTML] [PDF]

E.J. Levorson, P.R. Sreerekha, K.P. Chennazhi, F.K. Kasper, S.V. Nair, and A.G. Mikos, “Fabrication and Characterization of Multiscale Electrospun Scaffolds for Cartilage Regeneration,” Biomed. Mater., 8, 014103 (11pp) (2013).

[Abstract] [HTML] [PDF] [Interview with Erica Levorson]

R.A. Thibault, A.G. Mikos, and F.K. Kasper, “Scaffold/Extracellular Matrix Hybrid Constructs for Bone-Tissue Engineering,” Adv. Healthcare Mater., 2, 13-24 (2013).

[Abstract] [HTML] [PDF]

2012

A.A. Appel, J.C. Larson, S. Somo, Z. Zhong, P.P. Spicer, F.K. Kasper, A.B. Garson, A.M. Zysk, A.G. Mikos, M.A. Anastasio, and E.M. Brey, “Imaging of Poly(a-Hydroxy-Ester) Scaffolds with X-Ray Phase-Contrast Microcomputed Tomography,” Tissue Eng. Part C: Methods, 18, 859-865 (2012).

[Abstract] [HTML] [PDF]

A. Atala, F. K. Kasper, A. G. Mikos, “Engineering Complex Tissues,” Sci. Transl. Med. 4, 160rv12 (2012).

[Abstract] [HTML] [PDF]

R.L. Dahlin, V.V. Meretoja, M. Ni, F.K. Kasper, and A.G. Mikos, “Design of a High-Throughput Flow Perfusion Bioreactor System for Tissue Engineering,” Tissue Eng. Part C: Methods, 18, 817-820 (2012).

[Abstract] [HTML] [PDF]

P.P. Spicer, J.D. Kretlow, S. Young, J.A. Jansen, F.K. Kasper, and A.G. Mikos, “Evaluation of Bone Regeneration Using the Rat Critical Size Calvarial Defect,” Nature Protocols, 7, 1918-1929 (2012).

[Abstract] [HTML] [PDF]

E.L.S. Fong, B.M. Watson, F.K. Kasper, and A.G. Mikos, “Building Bridges: Leveraging Interdisciplinary Collaborations in the Development of Biomaterials to Meet Clinical Needs,” Adv. Mater., 24, 4995-5013 (2012).

[Abstract] [HTML] [PDF]

A.K. Ekenseair, K.W.M. Boere, S.N. Tzouanas, T.N. Vo, F.K. Kasper, and A.G. Mikos, “Structure-Property Evaluation of Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineering,” Biomacromolecules, 13, 2821-2830 (2012).

[Abstract] [HTML] [PDF]

T.E.L. Douglas, P.B. Messersmith, S. Chasan, A.G. Mikos, E.L.W. de Mulder, G. Dickson, D. Schaubroeck, L. Balcaen, F. Vanhaecke, P. Dubruel, J.A. Jansen, and S.C.G. Leeuwenburgh, “Enzymatic Mineralization of Hydrogels for Bone Tissue Engineering by Incorporation of Alkaline Phosphatase,” Macromol. Biosci., 12, 1077-1089 (2012).

[Abstract] [HTML] [PDF]

P.M. Mountziaris, S.N. Tzouanas, D.C. Sing, P.R. Kramer, F.K. Kasper, and A.G. Mikos, “Intra-Articular Controlled Release of Anti-Inflammatory siRNA with Biodegradable Polymer Microparticles Ameliorates Temporomandibular Joint Inflammation,” Acta Biomaterialia, 8, 3552-3560 (2012).

[Abstract] [HTML] [PDF]

T.N. Vo, F.K. Kasper, and A.G. Mikos, “Strategies for Controlled Delivery of Growth Factors and Cells for Bone Regeneration,” Adv. Drug Deliv. Rev., 64, 1292-1309 (2012).

[Abstract] [HTML] [PDF]

A.M. Henslee, D.-H. Gwak, A.G. Mikos, and F.K. Kasper, “Development of a Biodegradable Bone Cement for Craniofacial Applications,” J. Biomed. Mater. Res. Part A, 100A, 2252-2259 (2012).

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A.K. Ekenseair, K.W.M. Boere, S.N. Tzouanas, T.N. Vo, F.K. Kasper, and A.G. Mikos, “Synthesis and Characterization of Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineering,” Biomacromolecules, 13, 1908-1915 (2012).

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V.V. Meretoja, R.L. Dahlin, F.K. Kasper, and A.G. Mikos, “Enhanced Chondrogenesis in Co-Cultures with Articular Chondrocytes and Mesenchymal Stem Cells,” Biomaterials, 33, 6362-6369 (2012).

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L.A. Kinard, F.K. Kasper, and A.G. Mikos, “Synthesis of Oligo(Poly(Ethylene Glycol) Fumarate),” Nature Protocols, 7, 1219-1227 (2012).

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H. Wang, Z. Liu, D. Li, X. Guo, F.K. Kasper, C. Duan, J. Zhou, A.G. Mikos, and C. Wang, “Injectable Biodegradable Hydrogels for Embryonic Stem Cell Transplantation: Improved Cardiac Remodeling and Function of Myocardial Infarction,” J. Cell. Mol. Med., 16, 1310-1320 (2012).

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G. Somma, H.M. Alger, R.M. McGuire, J.D. Kretlow, F.R. Ruiz, S.A. Yatsenko, P. Stankiewicz, W. Harrison, E. Funk, A. Bergamaschi, J.S. Oghalai, A.G. Mikos, P.A. Overbeek, and F.A. Pereira, “Head Bobber: An Insertional Mutation Causes Inner Ear Defects, Hyperactive Circling, and Deafness,” J. Assoc. Res. Otolaryngol., 13, 335-349 (2012).

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C.J. Needham, A.K. Williams, S.A. Chew, F.K. Kasper, and A.G. Mikos, “Engineering a Polymeric Gene Delivery Vector Based on Poly(Ethylenimine) and Hyaluronic Acid,” Biomacromolecules, 13, 1429-1437 (2012).

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D. Dean, J. Wallace, A. Siblani, M.O. Wang, K. Kim, A.G. Mikos, and J.P. Fisher, “Continuous Digital Light Processing (cDLP): Highly Accurate Additive Manufacturing of Tissue Engineered Bone Scaffolds,” Virt. Phys. Prototyp., 7, 13-24 (2012).

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P.K. Avti, S. Hu, C. Favazza, A.G. Mikos, J.A. Jansen, K.R. Shroyer, L.V. Wang, and B. Sitharaman, “Detection, Mapping, and Quantification of Single Walled Carbon Nanotubes in Histological Specimens with Photoacoustic Microscopy,” PLoS ONE, 7(4), e35064 (2012).

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M.R. Nejadnik, A.G. Mikos, J.A. Jansen, and S.C.G. Leeuwenburgh, “Facilitating the Mineralization of Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogel by Incorporation of Hydroxyapatite Nanoparticles,” J. Biomed. Mater. Res. Part A, 100A, 1316-1323 (2012).

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P.M. Mountziaris, S.N. Tzouanas, and A.G. Mikos, “The Interplay of Bone-Like Extracellular Matrix and TNF-α Signaling on In Vitro Osteogenic Differentiation of Mesenchymal Stem Cells,” J. Biomed. Mater. Res. Part A, 100A, 1097-1106 (2012).

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P.P. Spicer, J.D. Kretlow, A.M. Henslee, M. Shi, S. Young, N. Demian, J.A. Jansen, M.E. Wong, A.G. Mikos, and F.K. Kasper, “In Situ Formation of Porous Space Maintainers in a Composite Tissue Defect,” J. Biomed. Mater. Res. Part A, 100A, 827-833 (2012).

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A.M. Martins, J.D. Kretlow, A.R. Costa-Pinto, P.B. Malafaya, E.M. Fernandes, N.M. Neves, C.M. Alves, A.G. Mikos, F.K. Kasper, and R.L. Reis, “Gradual Pore Formation in Natural Origin Scaffolds Throughout Subcutaneous Implantation,” J. Biomed. Mater. Res. Part A, 100A, 599-612 (2012).

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S. Srinivasan, R. Jayakumar, K.P. Chennazhi, E.J. Levorson, A.G. Mikos, and S.V. Nair, “Multiscale Fibrous Scaffolds in Regenerative Medicine,” Adv. Polym. Sci., 246, 1-20 (2012).

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2011

C. Nguyen, S. Young, J.D. Kretlow, A.G. Mikos, and M. Wong, “Surface Characteristics of Biomaterials Used for Space Maintenance in a Mandibular Defect: A Pilot Animal Study,” J. Oral Maxillofac. Surg., 69, 11-18 (2011).

[Abstract]

M. van der Zande, B. Sitharaman, X.F. Walboomers, L. Tran, J.S. Ananta, A. Veltien, L.J. Wilson, J.I. Álava, A. Heerschap, A.G. Mikos, and J.A. Jansen, “In Vivo Magnetic Resonance Imaging of the Distribution Pattern of Gadonanotubes Released from a Degrading Poly(Lactic-co-Glycolic Acid) Scaffold,” Tissue Eng. Part C: Methods, 17, 19-26 (2011).

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K. Kim, D. Dean, A. Lu, A.G. Mikos, and J.P. Fisher, “Early Osteogenic Signal Expression of Rat Bone Marrow Stromal Cells Is Influenced by Both Hydroxyapatite Nanoparticle Content and Initial Cell Seeding Density in Biodegradable Nanocomposite Scaffolds,” Acta Biomaterialia, 7, 1249-1264 (2011).

[Abstract] [PDF]

L. Klouda, K.R. Perkins, B.M. Watson, M.C. Hacker, S.J. Bryant, R.M. Raphael, F.K. Kasper, and A.G. Mikos, “Thermoresponsive, In Situ Crosslinkable Hydrogels Based on N-Isopropylacrylamide: Fabrication, Characterization and Mesenchymal Stem Cell Encapsulation,” Acta Biomaterialia, 7, 1460-1467 (2011).

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H. Liao, X.F. Walboomers, W.J.E.M. Habraken, Z. Zhang, Y. Li, D.W. Grijpma, A.G. Mikos, J.G.C. Wolke, and J.A. Jansen, “Injectable Calcium Phosphate Cement with PLGA, Gelatin and PTMC Microspheres in a Rabbit Femoral Defect,” Acta Biomaterialia, 7, 1752-1759 (2011).

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S.A. Chew, J.D. Kretlow, P.P. Spicer, A.W. Edwards, L.S. Baggett, Y. Tabata, F.K. Kasper, and A.G. Mikos, “Delivery of Plasmid DNA Encoding Bone Morphogenetic Protein-2 with a Biodegradable Branched Polycationic Polymer in a Critical-Size Rat Cranial Defect Model,” Tissue Eng. Part A, 17, 751-763 (2011).

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K. Kim, D. Dean, J. Wallace, R. Breithaupt, A.G. Mikos, and J.P. Fisher, “The Influence of Stereolithographic Scaffold Architecture and Composition on Osteogenic Signal Expression with Rat Bone Marrow Stromal Cells,” Biomaterials, 32, 3750-3763 (2011).

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P.M. Mountziaris, D.C. Sing, S.A. Chew, S.N. Tzouanas, E.D. Lehman, F.K. Kasper, and A.G. Mikos, “Controlled Release of Anti-Inflammatory siRNA from Biodegradable Polymeric Microparticles Intended for Intra-Articular Delivery to the Temporomandibular Joint,” Pharm. Res., 28, 1370-1384 (2011).

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M. Shi, J.D. Kretlow, P.P. Spicer, Y. Tabata, N. Demian, M.E. Wong, F.K. Kasper, and A.G. Mikos, “Antibiotic-Releasing Porous Polymethylmethacrylate/Gelatin/Antibiotic Constructs for Craniofacial Tissue Engineering,” J. Controlled Release, 152, 196-205 (2011).

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J.D. Kretlow and A.G. Mikos, “Bones to Biomaterials and Back Again – 20 Years of Taking Cues from Nature to Engineer Synthetic Polymer Scaffolds,” J. Biomed. Mater. Res. Part A, 98A, 323-331 (2011).

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M. Singh, M. Pierpoint, A.G. Mikos, and F.K. Kasper, “Chondrogenic Differentiation of Neonatal Human Dermal Fibroblasts Encapsulated in Alginate Beads with Hydrostatic Compression under Hypoxic Conditions in the Presence of Bone Morphogenetic Protein-2,” J. Biomed. Mater. Res. Part A, 98A, 412-424 (2011).

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J. Liao, K.E. Hammerick, G.A. Challen, M.A. Goodell, F.K. Kasper, and A.G. Mikos, “Investigating the Role of Hematopoietic Stem and Progenitor Cells in Regulating the Osteogenic Differentiation of Mesenchymal Stem Cells In Vitro,” J. Orthop. Res., 29, 1544-1553 (2011).

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A.M. Henslee, P.P. Spicer, D.M. Yoon, M.B. Nair, V.V. Meretoja, K.E. Witherel, J.A. Jansen, A.G. Mikos, and F.K. Kasper, “Biodegradable Composite Scaffolds Incorporating an Intramedullary Rod and Delivering Bone Morphogenetic Protein-2 for Stabilization and Bone Regeneration in Segmental Long Bone Defects,” Acta Biomaterialia, 7, 3627-3637 (2011).

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R.L. Dahlin, F.K. Kasper, and A.G. Mikos, “Polymeric Nanofibers in Tissue Engineering,” Tissue Eng. Part B: Reviews, 17, 349-364 (2011).

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M.B. Nair, J.D. Kretlow, A.G. Mikos, and F.K. Kasper, “Infection and Tissue Engineering in Segmental Bone Defects – A Mini Review,” Curr. Opin. Biotechnol., 22, 721-725 (2011).

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P.M. Mountziaris, P.P. Spicer, F.K. Kasper, and A.G. Mikos, “Harnessing and Modulating Inflammation in Strategies for Bone Regeneration,” Tissue Eng. Part B: Reviews, 17, 393-402 (2011).

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R.A. Thibault, A.G. Mikos, and F.K. Kasper, “Protein and Mineral Composition of Osteogenic Extracellular Matrix Constructs Generated with a Flow Perfusion Bioreactor,” Biomacromolecules, 12:4204-4212 (2011).

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M. Bongio, J.J.J.P. van den Beucken, M.R. Nejadnik, S.C.G. Leeuwenburgh, L.A. Kinard, F.K. Kasper, A.G. Mikos, and J.A. Jansen, “Biomimetic Modification of Synthetic Hydrogels by Incorporation of Adhesive Peptides and Calcium Phosphate Nanoparticles: In Vitro Evaluation of Cell Behavior,” Eur. Cells Mater., 22, 359-376 (2011).

[Abstract] [PDF]

2010

P.M. Mountziaris, S.N. Tzouanas, and A.G. Mikos, “Dose Effect of Tumor Necrosis Factor-α on In Vitro Osteogenic Differentiation of Mesenchymal Stem Cells on Biodegradable Polymeric Microfiber Scaffolds,” Biomaterials, 31, 1666-1675 (2010).

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A.S. Mistry, Q.P. Pham, C. Schouten, T. Yeh, E.M. Christenson, A.G. Mikos, and J.A. Jansen, “In Vivo Bone Biocompatibility and Degradation of Porous Fumarate-Based Polymer/Alumoxane Nanocomposites for Bone Tissue Engineering,” J. Biomed. Mater. Res. Part A, 92A, 451-462 (2010).

[Abstract] [HTML] [PDF]

X. Guo, H. Park, S. Young, J.D. Kretlow, J.J. van den Beucken, L.S. Baggett, Y. Tabata, F.K. Kasper, A.G. Mikos, and J.A. Jansen, “Repair of Osteochondral Defects with Biodegradable Hydrogel Composites Encapsulating Marrow Mesenchymal Stem Cells in a Rabbit Model,” Acta Biomaterialia, 6, 39-47 (2010).

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R.A. Thibault, L.S. Baggett, A.G. Mikos, and F.K. Kasper, “Osteogenic Differentiation of Mesenchymal Stem Cells on Pregenerated Extracellular Matrix Scaffolds in the Absence of Osteogenic Cell Culture Supplements,” Tissue Eng. Part A, 16, 431-440 (2010).

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A.M. Martins, C.M. Alves, F.K. Kasper, A.G. Mikos, and R.L. Reis, “Responsive and In Situ-Forming Chitosan Scaffolds for Bone Tissue Engineering Applications: An Overview of the Last Decade,” J. Mater. Chem., 20, 1638-1645 (2010).

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S.A. Chew, M.C. Hacker, A. Saraf, R.M. Raphael, F.K. Kasper, and A.G. Mikos, “Altering Amine Basicities in Biodegradable Branched Polycationic Polymers for Nonviral Gene Delivery,” Biomacromolecules, 11, 600-609 (2010).

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J.D. Kretlow, M.C. Hacker, L. Klouda, B.B. Ma, and A.G. Mikos, “Synthesis and Characterization of Dual Stimuli Responsive Macromers Based on Poly(N-Isopropylacrylamide) and Poly(Vinylphosphonic Acid),” Biomacromolecules, 11, 797-805 (2010).

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M. Shi, J.D. Kretlow, A. Nguyen, S. Young, L.S. Baggett, M.E. Wong, F.K. Kasper, and A.G. Mikos, “Antibiotic-Releasing Porous Polymethylmethacrylate Constructs for Osseous Space Maintenance and Infection Control,” Biomaterials, 31, 4146-4156 (2010).

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A. Saraf, L.S. Baggett, R.M. Raphael, F.K. Kasper, and A.G. Mikos, “Regulated Non-Viral Gene Delivery from Coaxial Electrospun Fiber Mesh Scaffolds,” J. Controlled Release, 143, 95-103 (2010).

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M.W. Zhang, H. Park, X. Guo, K. Nakamura, R.M. Raphael, F.K. Kasper, A.G. Mikos, and P.A. Tsonis, “Adapting Biodegradable Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels for Pigment Epithelial Cell Encapsulation and Lens Regeneration,” Tissue Eng. Part C: Methods, 16, 261-267 (2010).

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B. Sitharaman, M. van der Zande, J.S. Ananta, X. Shi, A. Veltien, X.F. Walboomers, L.J. Wilson, A.G. Mikos, A. Heerschap, and J.A. Jansen, “Magnetic Resonance Imaging Studies on Gadonanotube-Reinforced Biodegradable Polymer Nanocomposites,” J. Biomed. Mater. Res. Part A, 93A, 1454-1462 (2010).

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W.J.E.M. Habraken, H.B. Liao, Z. Zhang, J.G.C. Wolke, D.W. Grijpma, A.G. Mikos, J. Feijen, and J.A. Jansen, “In Vivo Degradation of Calcium Phosphate Cement Incorporated into Biodegradable Microspheres,” Acta Biomaterialia, 6, 2200-2211 (2010).

[Abstract]

J. Liao, X. Guo, D. Nelson, F.K. Kasper, and A.G. Mikos, “Modulation of Osteogenic Properties of Biodegradable Polymer/Extracellular Matrix Scaffolds Generated with a Flow Perfusion Bioreactor,” Acta Biomaterialia, 6, 2386-2393 (2010).

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E. Burdett, F.K. Kasper, A.G. Mikos, and J.A. Ludwig, “Engineering Tumors: A Tissue Engineering Perspective in Cancer Biology,” Tissue Eng. Part B: Reviews, 16, 351-359 (2010).

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X. Guo, J. Liao, H. Park, A. Saraf, R.M. Raphael, Y. Tabata, F.K. Kasper, and A.G. Mikos, “Effects of TGF-b3 and Preculture Period of Osteogenic Cells on the Chondrogenic Differentiation of Rabbit Marrow Mesenchymal Stem Cells Encapsulated in a Bilayered Hydrogel Composite,” Acta Biomaterialia, 6, 2920-2931 (2010).

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A.M. Martins, A. Saraf, R.A. Sousa, C.M. Alves, A.G. Mikos, F.K. Kasper, and R.L. Reis, “Combination of Enzymes and Flow Perfusion Conditions Improves Osteogenic Differentiation of Bone Marrow Stromal Cells Cultured upon Starch/Poly(ε-Caprolactone) Fiber Meshes,” J. Biomed. Mater. Res. Part A, 94A, 1061-1069 (2010).

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S.I. Ranganathan, D.M. Yoon, A.M. Henslee, M.B. Nair, C. Smid, F.K. Kasper, E. Tasciotti, A.G. Mikos, P. Decuzzi, and M. Ferrari, “Shaping the Micromechanical Behavior of Multi-Phase Composites for Bone Tissue Engineering,” Acta Biomaterialia, 6, 3448-3456 (2010).

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P.M. Mountziaris, D.C. Sing, A.G. Mikos, and P.R. Kramer, “Intra-Articular Microparticles for Drug Delivery to the TMJ,” J. Dent. Res., 89, 1039-1044 (2010).

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J. Liao, X. Guo, K.J. Grande-Allen, F.K. Kasper, and A.G. Mikos, “Bioactive Polymer/Extracellular Matrix Scaffolds Fabricated with a Flow Perfusion Bioreactor for Cartilage Tissue Engineering,” Biomaterials, 31, 8911-8920 (2010).

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P.P. Spicer and A.G. Mikos, “Fibrin Glue as a Drug Delivery System,” J. Controlled Release, 148, 49-55 (2010).

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J.D. Kretlow, M. Shi, S. Young, P.P. Spicer, N. Demian, J.A. Jansen, M.E. Wong, F.K. Kasper, and A.G. Mikos, “Evaluation of Soft Tissue Coverage over Porous Polymethylmethacrylate Space Maintainers within Nonhealing Alveolar Bone Defects,” Tissue Eng. Part C: Methods, 16, 1427-1438, 2010.

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K. Gkioni, S.C.G. Leeuwenburgh, T.E.L. Douglas, A.G. Mikos, and J.A. Jansen, “Mineralization of Hydrogels for Bone Regeneration,” Tissue Eng. Part B: Reviews, 16, 577-585 (2010).

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J.D. Kretlow, P.P. Spicer, J.A. Jansen, C.A. Vacanti, F.K. Kasper, and A.G. Mikos, “Uncultured Marrow Mononuclear Cells Delivered within Fibrin Glue Hydrogels to Porous Scaffolds Enhance Bone Regeneration within Critical-Sized Rat Cranial Defects,” Tissue Eng. Part A, 16, 3555-3568 (2010).

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2009

A. Saraf, G. Lozier, A. Haesslein, F.K. Kasper, R.M. Raphael, L.S. Baggett, and A.G. Mikos, “Fabrication of Nonwoven Coaxial Fiber Meshes by Electrospinning,” Tissue Eng. Part C: Methods, 15, 333-344 (2009).

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W.J.E.M. Habraken, J.G.C. Wolke, A.G. Mikos, and J.A. Jansen, “Porcine Gelatin Microsphere/Calcium Phosphate Cement Composites: An In Vitro Degradation Study,” J. Biomed. Mater. Res. Part B: Appl. Biomater., 91B, 555-561 (2009).

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E.W.H. Bodde, W.J.E.M. Habraken, A.G. Mikos, P.H.M. Spauwen, and J.A. Jansen, “Effect of Polymer Molecular Weight on the Bone Biological Activity of Biodegradable Polymer/Calcium Phosphate Cement Composites,” Tissue Eng. Part A, 15, 3183-3191 (2009).

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S.A. Chew, M.C. Hacker, A. Saraf, R.R. Raphael, F.K. Kasper, and A.G. Mikos, “Biodegradable Branched Polycationic Polymers with Varying Hydrophilic Spacers for Non-Viral Gene Delivery,” Biomacromolecules, 10, 2436-2445 (2009).

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W.J.E.M. Habraken, O.C. Boerman, J.G.C. Wolke, A.G. Mikos, and J.A. Jansen, “In Vitro Growth Factor Release from Injectable Calcium Phosphate Cements Containing Gelatin Microspheres,” J. Biomed. Mater. Res. Part A, 91A, 614-622 (2009).

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J.D. Kretlow, S. Young, L. Klouda, M. Wong, and A.G. Mikos, “Injectable Biomaterials for Regenerating Complex Craniofacial Tissues,” Adv. Mater., 21, 3368-3393 (2009).

[Abstract] [PDF]

S. Young, Z.S. Patel, J.D. Kretlow, M.B. Murphy, P.M. Mountziaris, L.S. Baggett, H. Ueda, Y. Tabata, J.A. Jansen, M. Wong, and A.G. Mikos, “Dose Effect of Dual Delivery of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein-2 on Bone Regeneration in a Rat Critical-Size Defect Model,” Tissue Eng. Part A, 15, 2347-2362 (2009).

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L. Klouda, M.C. Hacker, J.D. Kretlow, and A.G. Mikos, “Cytocompatibility Evaluation of Amphiphilic, Thermally Responsive and Chemically Crosslinkable Macromers for In Situ Forming Hydrogels,” Biomaterials, 30, 4558-4566 (2009).

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A.M. Martins, Q.P. Pham, P.B. Malafaya, R.M. Raphael, F.K. Kasper, R.L. Reis, and A.G. Mikos, “Natural Stimulus Responsive Scaffolds/Cells for Bone Tissue Engineering: Influence of Lysozyme upon Scaffold Degradation and Osteogenic Differentiation of Cultured Marrow Stromal Cells Induced by CaP Coatings,” Tissue Eng. Part A, 15, 1953-1963 (2009).

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K. Kim, D. Dean, A.G. Mikos, and J.P. Fisher, “Effect of Initial Cell Seeding Density on Early Osteogenic Signal Expression of Rat Bone Marrow Stromal Cells Cultured on Cross-Linked Poly(Propylene Fumarate) Disks,” Biomacromolecules, 10, 1810-1817 (2009).

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D.P. Link, J. van den Dolder, J.J.J.P. van den Beucken, W.J.E.M. Habraken, A. Soede, O.C. Boerman, A.G. Mikos, and J.A. Jansen, “Evaluation of an Orthotopically Implanted Calcium Phosphate Cement Containing Gelatin Microparticles,” J. Biomed. Mater. Res. Part A, 90A, 372-379 (2009).

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F.K. Kasper, K. Tanahashi, J.P. Fisher, and A.G. Mikos, “Synthesis of Poly(Propylene Fumarate),” Nature Protocols, 4, 518-525 (2009).

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X. Guo, H. Park, G. Liu, W. Liu, Y. Cao, Y. Tabata, F.K. Kasper, and A.G. Mikos, “In Vitro Generation of an Osteochondral Construct Using Injectable Hydrogel Composites Encapsulating Rabbit Marrow Mesenchymal Stem Cells,” Biomaterials, 30, 2741-2752 (2009).

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A.S. Mistry, S.H. Cheng, T. Yeh, E.M. Christenson, J.A. Jansen, and A.G. Mikos, “Fabrication and In Vitro Degradation of Porous Fumarate-Based Polymer/Alumoxane Nanocomposite Scaffolds for Bone Tissue Engineering,” J. Biomed. Mater. Res. Part A, 89A, 68-79 (2009).

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H. Park, X. Guo, J.S. Temenoff, Y. Tabata, A.I. Caplan, F.K. Kasper, and A.G. Mikos, “Effect of Swelling Ratio of Injectable Hydrogel Composites on Chondrogenic Differentiation of Encapsulated Rabbit Marrow Mesenchymal Stem Cells In Vitro,” Biomacromolecules, 10, 541-546 (2009).

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L. Klouda and A.G. Mikos, “Biomaterials, Drug Delivery and Bionanotechnology – The Research that Paved the Way: Professor Nicholas Peppas’ Research Over the Years,” Pharm. Res., 26, 599-600 (2009).

[Abstract]

M.C. Hacker, A. Haesslein, H. Ueda, W.J. Foster, C.A. Garcia, D.M. Ammon, R.N. Borazjani, J.F. Kunzler, J.C. Salamone, and A.G. Mikos, “Biodegradable Fumarate-Based Drug Delivery Systems for Ophthalmic Applications,” J. Biomed. Mater. Res. Part A, 88A, 976-989 (2009).

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H. Park, J.S. Temenoff, Y. Tabata, A.I. Caplan, R.M. Raphael, J.A. Jansen, and A.G. Mikos, “Effect of Dual Growth Factor Delivery on Chondrogenic Differentiation of Rabbit Marrow Mesenchymal Stem Cells Encapsulated in Injectable Hydrogel Composites,” J. Biomed. Mater. Res. Part A, 88A, 889-897 (2009).

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A.M. Martins, Q.P. Pham, P.B. Malafaya, R.A. Sousa, M.E. Gomes, R.M. Raphael, F.K. Kasper, R.L. Reis, and A.G. Mikos, “The Role of Lipase and a-Amylase in the Degradation of Starch/Poly(e-Caprolactone) Fiber Meshes and the Osteogenic Differentiation of Cultured Marrow Stromal Cells,” Tissue Eng. Part A, 15, 295-305 (2009).

[Abstract] [PDF]

P.M. Mountziaris, P.R. Kramer, and A.G. Mikos, “Emerging Intra-Articular Drug Delivery Systems for the Temporomandibular Joint,” Methods, 47, 134-140 (2009).

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Q.P. Pham, F.K. Kasper, A.S. Mistry, U. Sharma, A.W. Yasko, J.A. Jansen, and A.G. Mikos, “Analysis of the Osteoinductive Capacity and Angiogenicity of an In Vitro Generated Extracellular Matrix,” J. Biomed. Mater. Res. Part A, 88A, 295-303 (2009).

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A. Haesslein, M.C. Hacker, H. Ueda, D.M. Ammon, R.N. Borazjani, J.F. Kunzler, J.C. Salamone, and A.G. Mikos, “Matrix Modifications Modulate Ophthalmic Drug Delivery from Photo-Cross-Linked Poly(Propylene Fumarate)-Based Networks,” J. Biomater. Sci., Polym. Ed., 20, 49-69 (2009).

[Abstract]

2008

J.D. Kretlow and A.G. Mikos, “From Material to Tissue: Biomaterial Development, Scaffold Fabrication, and Tissue Engineering,” AIChE J., 54, 3048-3067 (2008).

J.D. Kretlow, Y.-Q. Jin, W. Liu, W.J. Zhang, T.-H. Hong, G. Zhou, L.S. Baggett, A.G. Mikos, and Y. Cao, “Donor Age and Cell Passage Affect Differentiation Potential of Murine Bone Marrow-Derived Stem Cells,” BMC Cell Biology, 9, 60 (2008).

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B. Sitharaman, T.Y. Zakharian, A. Saraf, P. Misra, J. Ashcroft, S. Pan, Q.P. Pham, A.G. Mikos, L.J. Wilson, and D.A. Engler, “Water-Soluble Fullerene (C60) Derivatives as Nonviral Gene-Delivery Vectors,” Mol. Pharmac., 5, 567-578 (2008).

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W.J.E.M. Habraken, L.T. de Jonge, J.G.C. Wolke, L. Yubao, A.G. Mikos, and J.A. Jansen, “Introduction of Gelatin Microspheres into an Injectable Calcium Phosphate Cement,” J. Biomed. Mater. Res. Part A, 87A, 643-655 (2008).

[Abstract] [HTML] [PDF]
E.W.H. Bodde, O.C. Boerman, F.G.M. Russel, A.G. Mikos, P.H.M. Spauwen, and J.A. Jansen, “The Kinetic and Biological Activity of Different Loaded rhBMP-2 Calcium Phosphate Cement Implants in Rats,” J. Biomed. Mater. Res. Part A, 87A, 780-791 (2008).

[Abstract] [HTML] [PDF]
D.P. Link, J. van den Dolder, J.J.J.P. van den Beucken, V.M. Cuijpers, J.G.C. Wolke, A.G. Mikos, and J.A. Jansen, “Evaluation of the Biocompatibility of Calcium Phosphate Cement/PLGA Microparticle Composites,” J. Biomed. Mater. Res. Part A, 87A, 760-769 (2008).

[Abstract] [HTML] [PDF]
Z.S. Patel, S. Young, Y. Tabata, J.A. Jansen, M.E.K. Wong, and A.G. Mikos, “Dual Delivery of an Angiogenic and an Osteogenic Growth Factor for Bone Regeneration in a Critical Size Defect Model,” Bone, 43, 931-940 (2008).

[Abstract]
E. Cosgriff-Hernandez and A.G. Mikos, “New Biomaterials as Scaffolds for Tissue Engineering,” Pharm. Res., 25, 2345-2347 (2008).

[Abstract]
Z.S. Patel, H. Ueda, M. Yamamoto, Y. Tabata, and A.G. Mikos, “In Vitro and In Vivo Release of Vascular Endothelial Growth Factor from Gelatin Microparticles and Biodegradable Composite Scaffolds,” Pharm. Res., 25, 2370-2378 (2008).

[Abstract]
J.P. Fisher, A.G. Mikos, P.C. Johnson, and J.A. Jansen, “A Continued Commitment to Quality Research in Tissue Engineering,” Tissue Eng. Part A, 14, 1457-1458 (2008).

[PDF]
S. Young, J.D. Kretlow, C. Nguyen, A.G. Bashoura, L.S. Baggett, J.A. Jansen, M. Wong, and A.G. Mikos, “Microcomputed Tomography Characterization of Neovascularization in Bone Tissue Engineering Applications,” Tissue Eng. Part B: Reviews, 14, 295-306 (2008).
[Abstract][ PDF]
W.J.E.M. Habraken, J.G.C. Wolke, A.G. Mikos, and J.A. Jansen, “PLGA Microsphere/Calcium Phosphate Cement Composites for Tissue Engineering: In Vitro Release and Degradation Characteristics,” J. Biomater. Sci., Polym. Ed., 19, 1171-1188 (2008).
[Abstract]
Z.S. Patel, M. Yamamoto, H. Ueda, Y. Tabata, and A.G. Mikos, “Biodegradable Gelatin Microparticles as Delivery Systems for the Controlled Release of Bone Morphogenetic Protein-2,” Acta Biomaterialia, 4, 1126-1138 (2008).
[HTML]
X. Shi, B. Sitharaman, Q.P. Pham, P.P. Spicer, J.L. Hudson, L.J. Wilson, J.M. Tour, R.M. Raphael, and A.G. Mikos, “In Vitro Cytotoxicity of Single-Walled Carbon Nanotube/Biodegradable Polymer Nanocomposites,” J. Biomed. Mater. Res. Part A, 86A, 813-823 (2008).
[Abstract] [HTML] [PDF]
B. Sitharaman, X. Shi, X.F. Walboomers, H. Liao, V. Cuijpers, L.J. Wilson, A.G. Mikos, and J.A. Jansen, “In Vivo Biocompatibility of Ultra-Short Single-Walled Carbon Nanotube/Biodegradable Polymer Nanocomposites for Bone Tissue Engineering,” Bone, 43, 362-370 (2008).
[HTML]
P.M. Mountziaris and A.G. Mikos, “Modulation of the Inflammatory Response for Enhanced Bone Tissue Regeneration,” Tissue Eng. Part B: Reviews, 14, 179-186 (2008).
[Abstract] [PDF]
M.C. Hacker, L. Klouda, B.B. Ma, J.D. Kretlow, and A.G. Mikos, “Synthesis and Characterization of Injectable, Thermally and Chemically Gelable, Amphiphilic Poly(N-Isopropylacrylamide)-Based Macromers,” Biomacromolecules, 9, 1558-1570 (2008).
[Abstract] [HTML] [PDF]
S. Young, A.G. Bashoura, T. Borden, L.S. Baggett, J.A. Jansen, M. Wong, and A.G. Mikos, “Development and Characterization of a Rabbit Alveolar Bone Nonhealing Defect Model,” J. Biomed. Mater. Res. Part A, 86A, 182-194 (2008).
[Abstract] [HTML] [PDF]
Q.P. Pham, F.K. Kasper, L.S. Baggett, R.M. Raphael, J.A. Jansen, and A.G. Mikos, “The Influence of an In Vitro Generated Bone-like Extracellular Matrix on Osteoblastic Gene Expression of Marrow Stromal Cells,” Biomaterials, 29, 2729-2739 (2008).
[HTML]
J.A. Jansen, A.G. Mikos, and P.C. Johnson, “A New Focus on the Methods of Tissue Engineering,” Tissue Eng. Part C: Methods, 14, 1 (2008).
[PDF]
W.J.E.M. Habraken, Z. Zhang, J.G.C. Wolke, D.W. Grijpma, A.G. Mikos, J. Feijen, and J.A. Jansen, “Introduction of Enzymatically Degradable Poly(Trimethylene Carbonate) Microspheres into an Injectable Calcium Phosphate Cement,” Biomaterials, 29, 2464-2476 (2008).
[HTML]
J.P. Fisher, A.G. Mikos, and P.C. Johnson, “Tomorrow’s Tissue Engineering Triumphs Require Understanding of Today’s Achievements,” Tissue Eng. Part B: Reviews, 14, 1 (2008).
[PDF]
A. Saraf, M.C. Hacker, B. Sitharaman, K.J. Grande-Allen, M.A. Barry, and A.G. Mikos, “Synthesis and Conformational Evaluation of a Novel Gene Delivery Vector for Human Mesenchymal Stem Cells,” Biomacromolecules, 9, 818-827 (2008).
[Abstract][HTML] [PDF]
Y. Khan, M.J. Yaszemski, A.G. Mikos, and C. Laurencin, “Tissue Engineering of Bone: Material and Matrix Considerations,” J. Bone Joint Surg., 90, 36-42 (2008).
[Abstract][HTML] [PDF]
E.W.H. Bodde, P.H.M. Spauwen, A.G. Mikos, and J.A. Jansen, “Closing Capacity of Segmental Radius Defects in Rabbits,” J. Biomed. Mater. Res. Part A, 85A, 206-217 (2008).
[Abstract] [HTML] [PDF]
D.P. Link, J. van den Dolder, J.J. van den Beucken, J.G. Wolke, A.G. Mikos, and J.A. Jansen, “Bone Response and Mechanical Strength of Rabbit Femoral Defects Filled with Injectable CaP Cements Containing TGF-β1 Loaded Gelatin Microparticles,” Biomaterials, 29, 675-682 (2008).
[HTML]
L. Klouda and A.G. Mikos, “Thermoresponsive Hydrogels in Biomedical Applications ,” Eur. J. Pharm. Biopharm., 68, 34-45 (2008).
[HTML]
A. Haesslein, M.C. Hacker, and A.G. Mikos, “Effects of Macromer Molecular Weight on In Vitro Opthalmic Drug Release from Photo-Crosslinked Matricies ,” Acta Biomater., 4, 1-10 (2008).
[HTML]

2007

E.M. Christenson, W. Soofi, J.L. Holm, N.R. Cameron, and A.G. Mikos, “Biodegradable Fumarate-Based PolyHIPEs as Tissue Engineering Scaffolds,” Biomacromolecules, 8, 3806-3814 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

P.C. Johnson, A.G. Mikos, J.P. Fisher, and J.A. Jansen, “Strategic Directions in Tissue Engineering,” Tissue Eng., 13, 2827-2837 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

A.S. Mistry, A.G. Mikos, and J.A. Jansen, “Degradation and Biocompatibility of a Poly(Propylene Fumarate)-Based/Alumoxane Nanocomposite for Bone Tissue Engineering,” J. Biomed. Mater. Res. Part A, 83A, 940-953 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

S. Kaihara, S. Matsumura, A.G. Mikos, and J.P. Fisher, “Synthesis of Poly(L-Lactide) and Polyglycolide by Ring-Opening Polymerization,” Nature Prot., 2, 2767-2771 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

H. Ueda, M.C. Hacker, A. Haesslein, S. Jo, D.M. Ammon, R.N. Borazjani, J.F. Kunzler, J.C. Salamone, and A.G. Mikos, “Injectable, In Situ Forming Poly(Propylene Fumarate)-Based Ocular Drug Delivery Systems,” J. Biomed. Mater. Res. Part A, 83A, 656-666 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

S.C.G. Leeuwenburgh, John A. Jansen, and A.G. Mikos, “Functionalization of Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels with Finely Dispersed Calcium Phosphate Nanocrystals for Bone-Substituting Purposes,” J. Biomater. Sci. Polym. Ed., 18, 1547-1564 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

M.B. Murphy, J.D. Hartgerink, A. Goepferich, and A.G. Mikos, “Synthesis and In Vitro Hydroxyapatite Binding of Peptides Conjugated to Calcium-Binding Moieties,” Biomacromolecules, 8, 2237-2243 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

X. Shi, B. Sitharaman, Q.P. Pham, F. Liang, K. Wu, W.E. Billups, L.J. Wilson, and A.G. Mikos, “Fabrication of Porous Ultra-Short Single-Walled Carbon Nanotube Nanocomposite Scaffolds for Bone Tissue Engineering,” Biomaterials, 28, 4078-4090 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

B. Sitharaman, L.A. Tran, Q.P. Pham, R.D. Bolskar, R. Muthupillai, S.D. Flamm, A.G. Mikos, and L.J. Wilson, “Gadofullerenes as Nanoscale Magnetic Labels for Cellular MRI,” Contrast Media Mol. Imaging, 2, 139-146 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

H. Castano-Izquierdo, J. Alvarez-Barreto, J. van den Dolder, J.A. Jansen, A.G. Mikos, and V.I. Sikavitsas, “Pre-Culture Period of Mesenchymal Stem Cells in Osteogenic Media Influences their In Vivo Bone Forming Potential,” J. Biomed. Mater. Res. Part A, 82A, 129-138 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

J.M. Ashcroft, K.B. Hartman, K.R. Kissell, Y. Mackeyev, S. Pheasant, S. Young, P.A.W. Van der Heide, A.G. Mikos, and L.J. Wilson, “Single-Molecule I2@US-Tube Nanocapsules: A New X-Ray Contrast-Agent Design,” Adv. Mater., 19, 573-576 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

J.D. Kretlow, L. Klouda, and A.G. Mikos, “Injectable Matrices and Scaffolds for Drug Delivery in Tissue Engineering,” Adv. Drug Deliv. Rev., 59, 263-273 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

M. Hacker, M. Ringhofer, B. Appel, M. Neubauer, T. Vogel, S. Young, A.G. Mikos, T. Blunk, A. Göpferich, and M.B. Schulz, “Solid Lipid Templating of Macroporous Tissue Engineering Scaffolds,” Biomaterials, 28, 3497-3507 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

B. Sitharaman, X. Shi, L.A. Tran, P.P. Spicer, I. Rusakova, L.J. Wilson, and A.G. Mikos, “Injectable In Situ Crosslinkable Nanocomposites of Biodegradable Polymers and Carbon Nanostructures for Bone Tissue Engineering,” J. Biomater. Sci., Polym. Ed., 18, 655-671 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

J.D. Kretlow and A.G. Mikos, “Mineralization of Synthetic Polymer Scaffolds for Bone Tissue Engineering,” Tissue Eng., 13, 927-938 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

H. Park, J.S. Temenoff, Y. Tabata, A.I. Caplan, and A.G. Mikos, “Injectable Biodegradable Hydrogel Composites for Rabbit Marrow Mesenchymal Stem Cell and Growth Factor Delivery for Cartilage Tissue Engineering,” Biomaterials, 28, 3217-3227 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

T.A. Holland, E.W.H. Bodde, V.M.J.I. Cuijpers, L.S. Baggett, Y. Tabata, A.G. Mikos, and J.A. Jansen, “Degradable Hydrogel Scaffolds for In Vivo Evaluation of Growth Factor Interactions in Cartilage Repair,” Osteoarthritis Cartilage, 15, 187-197 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

E.M. Christenson, K.S. Anseth, J.J.J.P. van den Beucken, C.K. Chan, B. Ercan, J.A. Jansen, C.T. Laurencin, W.-J. Li, R. Murugan, L.S. Nair, S. Ramakrishna, R.S. Tuan, T.J. Webster, and A.G. Mikos, “Nanobiomaterial Applications in Orthopaedics,” J. Orthop. Res., 25, 11-22 (2007).

[Abstract Available on PubMed] [HTML] [PDF]

2006

A.G. Mikos, S.W. Herring, P. Ochareon, J. Elisseeff, H.H. Lu, R. Kandel, F.J. Schoen, M. Toner, D. Mooney, A. Atala, M.E. van Dyke, D. Kaplan, and G. Vunjak-Novakovic, “Engineering Complex Tissues,” Tissue Eng., 12, 3307-3339 (2006).

[Abstract Available on PubMed] [HTML] [PDF]
Q.P. Pham*, U. Sharma*, and A.G. Mikos,”Electrospun Poly(e-Caprolactone) Microfiber and Multilayer Nanofiber/Microfiber Scaffolds: Characterization of Scaffolds and Measurement of Cellular Infiltration,” Biomacromolecules, 7, 2796-2805 (2006). (* Q.P.P and U.S. contributed equally to this work)

[Abstract Available on PubMed] [HTML] [PDF]
M.C. Hacker and A.G. Mikos, “Trends in Tissue Engineering Research,” Tissue Eng., 12, 2049-2057 (2006).

[Abstract Available on PubMed] [HTML] [PDF]
T.A. Holland and A.G. Mikos, “Biodegradable Polymeric Scaffolds, Improvements in Bone Tissue Engineering through Controlled Drug Delivery,” Adv. Biochem. Eng. Biotechnol., 102, 161-185 (2006).

[Abstract Available on PubMed] [HTML] [PDF]
P.Q. Ruhe, O.C. Boerman, F.G.M. Russel, A.G. Mikos, P.H.M. Spauwen, and J.A. Jansen, “In Vivo Release of rhBMP-2 Loaded Porous Calcium Phosphate Cement Pretreated with Albumin,” J. Mater. Sci., Mater. Med., 17, 919-927 (2006).

[Abstract Available on PubMed] [HTML] [PDF]
W.J.E.M. Habraken, J.G.C. Wolke, A.G. Mikos, and J.A. Jansen, “Injectable PLGA Microsphere/Calcium Phosphate Cements: Physical Properties and Degradation Characteristics,” J. Biomater. Sci. Polym. Ed., 17, 1057–1074 (2006).

[Abstract Available on PubMed] [HTML] [PDF]
A. Haesslein*, H. Ueda*, and M.C. Hacker*, S. Jo, D.M. Ammon, R.N. Borazjani, J.F. Kunzler, J.C. Salamone, and A.G. Mikos, “Long-Term Release of Fluocinolone Acetonide Using Biodegradable Fumarate-Based Polymers,” J. Controlled Release, 114, 251-260 (2006). (* A.H., H.U., and M.C.H. contributed equally to this work)

[Abstract Available on PubMed] [Full Text]
A.G. Mikos and P.C. Johnson, “Editorial: Redefining Tissue Engineering . . . And Our New Rapid Publication Policy,” Tissue Eng., 12, 1379-1380 (2006).

[No Abstract Available] [HTML] [PDF]
X. Shi, J.L. Hudson, P.P. Spicer, J.M. Tour, R. Krishnamoorti, and A.G. Mikos, “Injectable Nanocomposites of Single-Walled Carbon Nanotubes and Biodegradable Polymers for Bone Tissue Engineering,” Biomacromolecules, 7, 2237-2242 (2006).

[Abstract Available on PubMed] [HTML] [PDF]
A. Saraf and A.G. Mikos, “Gene Delivery Strategies for Cartilage Tissue Engineering,” Adv. Drug Deliv. Rev., 58, 592-603 (2006).

[Abstract Available on PubMed] [Full Text]
W.T. Godbey and A.G. Mikos, “Gene Delivery for Tissue Engineering,” Adv. Drug Deliv. Rev., 58, 465-466 (2006).

[No Abstract Available] [Full Text]
F.K. Kasper, E. Jerkins, K. Tanahashi, M.A. Barry, Y. Tabata, and A.G. Mikos, “Characterization of DNA Release From Composites of Oligo(poly(ethylene glycol) fumarate) and Cationized Gelatin Microspheres In Vitro,” J. Biomed. Mater. Res. Part A, 78, 823-835 (2006).

[Abstract Available on PubMed] [HTML] [PDF]
Q.P. Pham*, U. Sharma*, and A.G. Mikos, “Electrospinning of Polymeric Nanofibers for Tissue Engineering Applications,” Tissue Eng., 12, 1197-1211 (2006) (* Q.P.P. and U.S. contributed equally to this work)

[Abstract Available on PubMed] [HTML] [PDF]
M.E. Gomes, H.L. Holtorf, R.L Reis, and A.G. Mikos, “Influence of the Porosity of Starch-Based Fiber Mesh Scaffolds on the Proliferation and Osteogenic Differentiation of Bone Marrow Stromal Cells Cultured in a Flow Perfusion Bioreactor,” Tissue Eng., 12, 801-809 (2006).

[Abstract Available on PubMed] [HTML] [PDF]
P.Q. Ruhe, E.L. Hedberg-Dirk, N.T. Padron, P.H. Spauwen, J.A. Jansen, and A.G. Mikos, “Porous Poly(DL-Lactic-co-Glycolic Acid)/Calcium Phosphate Cement Composite for Reconstruction of Bone Defects,” Tissue Eng., 12, 789-800 (2006).

[Abstract Available on PubMed] [HTML] [PDF]
F.K. Kasper, S. Young, K. Tanahashi, M.A. Barry, Y. Tabata, J.A. Jansen, and A.G. Mikos, “Evaluation of Bone Regeneration by DNA Release from Composites of Oligo(Poly(Ethylene Glycol) Fumarate) and Cationized Gelatin Microspheres in a Critical-Sized Calvarial Defect,” J. Biomed. Mater. Res. Part A, 78, 335-242 (2006).

[Abstract Available on PubMed] [HTML] [PDF]
N. Datta*, Q.P. Pham*, U. Sharma*, V.I. Sikavitsas, J.A. Jansen, and A.G. Mikos, “In Vitro Generated Extracellular Matrix and Fluid Shear Stress Synergistically Enhance 3D Osteoblastic Differentiation,” Proceed. Natl. Acad. Sci. USA, 103, 2488-2493 (2006). (* N.D., Q.P.P., and U.S. contributed equally to this work)

[Abstract Available on PubMed] [HTML] [PDF]

M.E. Gomes, C.M. Bossano, C.M. Johnston, R.L. Reis, and A.G. Mikos, “In Vitro Localization of Bone Growth Factors in Constructs of Biodegradable Scaffolds Seeded with Marrow Stromal Cells and Cultured in a Flow Perfusion Bioreactor,” Tissue Eng., 12, 177-188 (2006).

[Abstract Available on PubMed] [Full Text]

2005

S. Young, M. Wong, Y. Tabata, and A.G. Mikos, “Gelatin as a Delivery Vehicle for the Controlled Release of Bioactive Molecules,” J. Controlled Release, 109, 256-274 (2005).

[Abstract Available on PubMed] [PDF] [HTML]

C.Y. Lin, R.M. Schek, A.S. Mistry, X. Shi, A.G. Mikos, P.H. Krebsbach, and S.J. Hollister, “Functional Bone Engineering Using ex Vivo Gene Therapy and Topology-Optimized, Biodegradable Polymer Composite Scaffolds,” Tissue Eng., 11, 1589-1598 (2005).

[Abstract Available on PubMed] [PDF] [HTML]

E.L. Hedberg, H.C. Kroese-Deutman, C.K. Shih, J.J. Lemoine, M.A. Liebschner, M.J. Miller, A.W. Yasko, R.S. Crowther, D.H. Carney, A.G. Mikos, and J.A. Jansen, “Methods: A Comparative Analysis of Radiography, Microcomputed Tomography, and Histology for Bone Tissue Engineering,” Tissue Eng., 11, 1356-1367 (2005).

[Abstract Available on PubMed] [PDF] [HTML]

Z. Lalani, M. Wong, E.M. Brey, A.G. Mikos, P.J. Duke, M.J. Miller, C. Johnston, and D. Montufar-Solis, “Spatial and Temporal Localization of FGF-2 and VEGF in Healing Tooth Extraction Sockets in a Rabbit Model,” J. Oral Maxillofac. Surg., 63, 1500-1508 (2005).

[Abstract Available on PubMed] [PDF] [HTML]

F.K. Kasper, T. Kushibiki, Y. Kimura, A.G. Mikos, and Y. Tabata, “In Vivo Release of Plasmid DNA from Composites of Oligo(Poly(Ethylene Glycol) Fumarate) and Cationized Gelatin Microspheres,” J. Controlled Release, 107, 547-561 (2005).

[Abstract Available on PubMed] [PDF] [HTML]

T.A. Holland, E.W.H. Bodde, L.S. Baggett, Y. Tabata, A.G. Mikos, and J.A. Jansen, “Osteochondral Repair in the Rabbit Model Utilizing Bilayered, Degradable Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogel Scaffolds,” J. Biomed. Mater. Res. Part A, 75A, 156-167 (2005).

[Abstract Available on PubMed] [PDF] [HTML]

P.Q. Ruhé, O.C. Boerman, F.G.M. Russel, P.H.M. Spauwen, A.G. Mikos, and J.A. Jansen, “Controlled Release of rhBMP-2 Loaded Poly(DL-Lactic-co-Glycolic Acid)/Calcium Phosphate Cement Composites In Vivo,” J. Controlled Release, 106, 162-171 (2005).

[Abstract Available on PubMed] [PDF] [HTML]

P.Q. Ruhé, E.L. Hedberg, N.T. Padron, P.H.M. Spauwen, J.A. Jansen, and A.G. Mikos, “Biocompatibility and Degradation of Poly(DL-Lactic-co-Glycolic Acid)/Calcium Phosphate Cement Composites,” J. Biomed. Mater. Res. Part A, 74A, 533-544 (2005).

[Abstract Available on PubMed] [PDF] [HTML]

H. Park, J.S. Temenoff, T.A. Holland, Y. Tabata, and A.G. Mikos, “Delivery of TGF-b1 and Chondrocytes via Injectable, Biodegradable Hydrogels for Cartilage Tissue Engineering Applications,” Biomaterials, 26, 7095-7103 (2005).

[Abstract Available on PubMed] [PDF] [HTML]

D. Dean, M.S. Wolfe, Y. Ahmad, A. Totonchi, J.E.-K. Chen, J.P. Fisher, M.N. Cooke, C.M. Rimnac, D.P. Lennon, A.I. Caplan, N.S. Topham, and A.G. Mikos, “Effect of Transforming Growth Factor b2 on Marrow-Infused Foam Poly(Propylene Fumarate) Tissue-Engineered Constructs for the Repair of Critical-Size Cranial Defects in Rabbits,” Tissue Eng., 11, 923-939 (2005).

[Abstract Available on PubMed] [PDF] [HTML]

H.L. Holtorf, T.L. Sheffield, C.G. Ambrose, J.A. Jansen, and A.G. Mikos, “Flow Perfusion Culture of Marrow Stromal Cells Seeded on Porous Biphasic Calcium Phosphate Ceramics,” Ann. Biomed. Eng., 33, 1238-1248 (2005).

[Abstract Available on PubMed] [PDF] [HTML]

H.L. Holtorf, N. Datta, J.A. Jansen, and A.G. Mikos, “Scaffold Mesh Size Affects the Osteoblastic Differentiation of Seeded Marrow Stromal Cells Cultured in a Flow Perfusion Bioreactor,” J. Biomed. Mater. Res. Part A, 74A, 171-180 (2005).

[Abstract Available on PubMed] [PDF] [HTML]

H.L. Holtorf, J.A. Jansen, and A.G. Mikos, “Ectopic Bone Formation in Rat Marrow Stromal Cell/Titanium Fiber Mesh Scaffold Constructs: Effect of Initial Cell Phenotype,” Biomaterials, 26, 6208-6216 (2005).

[Abstract Available on PubMed] [PDF] [HTML]

X. Shi, J.L. Hudson, P.P. Spicer, J.M. Tour, R. Krishnamoorti, and A.G. Mikos, “Rheological Behavior and Mechanical Characterization of Injectable Poly(Propylene Fumarate)/Single-Walled Carbon Nanotube Composites for Bone Tissue Engineering,” Nanotechnology, 16, S531-S538 (2005).

[Abstract Available on PubMed] [PDF] [HTML]

F.K. Kasper, S.K. Seidlits, A. Tang, R.S. Crowther, D.H. Carney, M.A. Barry, and A.G. Mikos, “In Vitro Release of Plasmid DNA from Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels,” J. Controlled Release, 104, 521-539 (2005).

[Abstract Available on PubMed] [PDF] [HTML]
A.S. Mistry and A.G. Mikos, “Tissue Engineering Strategies for Bone Regeneration,” Adv. Biochem. Eng. Biotechnol., 94, 1-22 (2005).

[Abstract Available on PubMed] [PDFF] [HTML]
L.A. Solchaga, J.S. Temenoff, J. Gao, A.G. Mikos, A.I. Caplan, and V.M. Goldberg, “Repair of Osteochondral Defects with Hyaluronan- and Polyester-based Scaffolds,” Osteoarthritis Cartilage, 13, 297-309 (2005).

[Abstract Available on PubMed] [PDF] [HTML]
E.L. Hedberg, H.C. Kroese-Deutman, C.K. Shih, R.S. Crowther, D.H. Carney, A.G. Mikos, and J.A. Jansen, “In Vivo Degradation of Porous Poly(propylene fumarate)/Poly(DL-lactic-co-glycolic acid) Composite Scaffolds,” Biomaterials, 26, 4616-4623 (2005).

[Abstract Available on PubMed] [PDF] [HTML]
V.I. Sikavitsas, G.N. Bancroft, J.J. Lemoine, M.A. Liebschner, M. Dauner, and A.G. Mikos, “Flow Perfusion Enhances the Calcified Matrix Deposition of Marrow Stromal Cells in Biodegradable Nonwoven Fiber Mesh Scaffolds,” Ann. Biomed. Eng., 33, 63-70 (2005).

[Abstract Available on PubMed] [PDF] [HTML]
E.L. Hedberg, H.C. Kroese-Deutman, C.K. Shih, R.S. Crowther, D.H. Carney, A.G. Mikos, and J.A. Jansen, “Effect of Varied Release Kinetics of the Osteogenic Thrombin Peptide TP508 from Biodegradable, Polymeric Scaffolds on Bone Formation in Vivo,” J. Biomed. Mater. Res. Part A, 72A, 343-353 (2005).

[Abstract Available on PubMed] [PDF] [HTML]
H.L. Holtorf, J.A. Jansen, and A.G. Mikos, “Flow Perfusion Culture Induces the Osteoblastic Differentiation of Marrow Stromal Cell-Scaffold Constructs in the Absence of Dexamethasone,” J. Biomed. Mater. Res. Part A, 72A, 326-334 (2005).

[Abstract Available on PubMed] [PDF] [HTML]
H. Shin, J.S. Temenoff, G.C. Bowden, K. Zygourakis, M.C. Farach-Carson, M.J. Yaszemski, and A.G. Mikos, “Osteogenic Differentiation of Rat Bone Marrow Stromal Cells Cultured on Arg–Gly–Asp Modified Hydrogels Without Dexamethasone and β-Glycerol Phosphate,” Biomaterials, 26, 3645-3654 (2005).

[Abstract Available on PubMed] [PDF] [HTML]
E.L. Hedberg, C.K. Shih, J.J. Lemoine, M.D. Timmer, M.A. Liebschner, J.A. Jansen, and A.G. Mikos, “In Vitro Degradation of Porous Poly(propylene fumarate)/Poly(DL-lactic-co-glycolic acid) Composite Scaffolds,” Biomaterials, 26, 3215-3225 (2005).

[Abstract Available on PubMed] [PDF] [HTML]
J.A. Jansen, J.W.M. Vehof, P.Q. Ruhé, H. Kroeze-Deutman, Y. Kuboki, H. Takita, E.L. Hedberg, and A.G. Mikos, “Growth Factor-Laded Scaffolds for Bone Engineering,” J. Controlled Release, 101, 127-136 (2005).

[Abstract Available on PubMed] [PDF] [HTML]
T.A. Holland, Y. Tabata, and A.G. Mikos, “Dual Growth Factor Delivery from Degradable Oligo(poly(ethylene glycol) fumarate) Hydrogel Scaffolds for Cartilage Tissue Engineering,” J. Controlled Release, 101, 111-125 (2005).

[Abstract Available on PubMed] [PDF] [HTML]
N. Datta, H.L. Holtorf, V.I. Sikavitsas, J.A. Jansen, and A.G. Mikos, “Effect of Bone Extracellular Matrix Synthesized In Vitro on the Osteoblastic Differentiation of Marrow Stromal Cells,” Biomaterials, 26, 971-977 (2005).

[Abstract Available on PubMed] [PDF] [HTML]

2004

E.L. Hedberg, C.K. Shih, L.A. Solchaga, A.I. Caplan, and A.G. Mikos, “Controlled Release of Hyaluronan Oligomers from Biodegradable Polymeric Microparticle Carriers,” J. Control. Release, 100, 257-266 (2004).

[Abstract Available on PubMed] [PDF] [HTML]
J.P. Fisher, S. Jo, A.G. Mikos, and A.H. Reddi, “Thermoreversible Hydrogel Scaffolds for Articular Cartilage Engineering,” J. Biomed. Mater. Res., 71A, 268-274 (2004).

[Abstract Available on PubMed] [PDF] [HTML]
R.A. Horch, N. Shahid, A.S. Mistry, M.D. Timmer, A.G. Mikos, and A.R. Barron, “Nanoreinforcement of Poly(Propylene Fumarate)-Based Networks with Surface Modified Alumoxane Nanoparticles for Bone Tissue Engineering,” Biomacromolecules, 5, 1990-1998 (2004).

[Abstract Available on PubMed] [PDF] [HTML]
J.S. Blum, J.S. Temenoff, H. Park, J.A. Jansen, A.G. Mikos, and M.A. Barry, “Development and Characterization of Enhanced Green Fluorescent Protein and Luciferase Expressing Cell Line for Non-Destructive Evaluation of Tissue Engineering Constructs,” Biomaterials, 25, 5809-5819 (2004).

[Abstract Available on PubMed] [PDF] [HTML]
Z.S. Patel and A.G. Mikos, “Angiogenesis with Biomaterial-Based Drug- and Cell-Delivery Systems,” J. Biomater. Sci., Polym. Ed., 15, 701-726 (2004).

[Abstract Available on PubMed] [PDF] [HTML]
J.S. Temenoff, H. Park, E. Jabbari, T.L. Sheffield, R.G. LeBaron, C.G. Ambrose, and A.G. Mikos, “In Vitro Osteogenic Differentiation of Marrow Stromal Cells Encapsulated in Biodegradable Hydrogels,” J. Biomed. Mater. Res. Part A, 70A, 235-244 (2004).

[Abstract Available on PubMed] [PDF] [HTML]
H. Shin, K. Zygourakis, M.C. Farach-Carson, M.J. Yaszemski, and A.G. Mikos, “Modulation of Differentiation and Mineralization of Marrow Stromal Cells Cultured on Biomimetic Hydrogels Modified with Arg-Gly-Asp Containing Peptides,” J. Biomed. Mater. Res. Part A, 69A, 535-543 (2004).

[Abstract Available on PubMed] [PDF] [HTML]
C.G. Ambrose, T.A. Clyburn, K. Louden, J. Joseph, J. Wright, P. Gulati, G.R. Gogola, and A.G. Mikos, “Effective Treatment of Osteomyelitis with Biodegradable Microspheres in a Rabbit Model,” Clin. Orthop. Rel. Res., 421, 293-299 (2004).

[Abstract Available on PubMed] [PDF] [HTML]
Z. Lalani, M.E.K. Wong, E.M. Brey, A.G. Mikos, P.J. Duke, and C. Johnston, “Spatial and Temporal Localization of Secretory IgA in Healing Tooth Extraction Sockets in a Rabbit Model,” J. Oral Maxillofac. Surg., 62, 466-472 (2004).

[Abstract Available on PubMed] [PDF] [HTML]
J.S. Blum, M.B. Parrott, A.G. Mikos, and M.A. Barry, “Early Osteoblastic Differentiation Induced by Dexamethasone Enhances Adenoviral Gene Delivery to Marrow Stromal Cells,” J. Orthop. Res., 22, 411-416 (2004).

[Abstract Available on PubMed] [PDF] [HTML]
J.P. Fisher, Z. Lalani, C.M. Bossano, E.M. Brey, N. Demian, C.M. Johnston, D. Dean, J.A. Jansen, M.E.K. Wong, and A.G. Mikos, “Effect of Biomaterial Properties on Bone Healing in a Rabbit Tooth Extraction Socket Model,” J. Biomed. Mater. Res. Part A, 68A, 428-438 (2004).

[Abstract Available on PubMed] [PDF] [HTML]
J.S. Temenoff, H. Park, E. Jabbari, D.E. Conway, T.L. Sheffield, C.G. Ambrose, and A.G. Mikos, “Thermally Cross-Linked Oligo(poly(ethylene glycol) fumarate) Hydrogels Support Osteogenic Differentiation of Encapsulated Marrow Stromal Cells In Vitro,” Biomacromolecules, 5, 5-10 (2004).

[Abstract Available on PubMed] [PDF] [HTML]
T.A. Holland, J.K.V. Tessmar, Y. Tabata, and A.G. Mikos, “Transforming Growth Factor-b1 Release from Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels in Conditions Which Model the Cartilage Wound Healing Environment,” J. Controlled Release, 94, 101-114 (2004).

[Abstract Available on PubMed] [PDF] [HTML]
H. Shin, K. Zygourakis, M.C. Farach-Carson, M.J. Yaszemski, and A.G. Mikos, “Attachment, Proliferation, and Migration of Marrow Stromal Osteoblasts Cultured on Biomimetic Hydrogels Modified with an Osteopontin-Derived Peptide,” Biomaterials, 25, 895-906 (2004).

[Abstract Available on PubMed] [PDF] [HTML]

2003

V.I. Sikavitsas, G.N. Bancroft, H.L. Holtorf, J.A. Jansen, and A.G. Mikos, “Mineralized Matrix Deposition by Marrow Stromal Osteoblasts in 3D Perfusion Culture Increases with Increasing Fluid Shear Forces,” Proceed. Natl. Acad. Sci. USA, 100, 14683-14688 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
 J.S. Blum, M.A. Barry, A.G. Mikos, and J.A. Jansen, “In Vivo Evaluation of Gene Therapy Vectors in Ex Vivo Derived Marrow Stromal Cells for Bone Regeneration in a Rat Critical Size Calvarial Defect Model,” Human Gene Therapy, 14, 1689-1701 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
C.G. Ambrose, G.R. Gogola, T.A. Clyburn, A.K. Raymond, A.S. Peng, and A.G. Mikos, “Antibiotic Microspheres: Preliminary Testing for Potential Treatment of Osteomyelitis,” Clin. Orthop. Rel. Res., 415, 279-285 (2003).

[Abstract Available on PubMed] [HTML]
K. Tanahashi and A.G. Mikos, “Effect of Hydrophilicity and Agmatine Modification on Degradation of Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels,” J. Biomed. Mater. Res. Part A, 67A, 1148-1154 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
J.S. Blum, M.A. Barry, and A.G. Mikos, “Bone Regeneration through Transplantation of Genetically Modified Cells,” Clin. Plast. Surg., 30, 611-620 (2003).

[Abstract Available on PubMed]
V.I. Sikavitsas, J. van den Dolder, G.N. Bancroft, P.H.M. Spauwen, J.A. Jansen, and A.G. Mikos, “Influence of the In Vitro Culture Period on the In Vivo Performance of Cell/Titanium Bone Tissue Engineered Constructs Using a Rat Cranial Critical Size Defect Model,” J. Biomed. Mater. Res. Part A, 67A, 944-951 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
J.S. Temenoff, H. Shin, D.E. Conway, P.S. Engel, and A.G. Mikos, “In Vitro Cytotoxicity of Redox Radical Initiators for Crosslinking of Oligo(Poly(Ethylene Glycol) Fumarate) Macromers,” Biomacromolecules, 4, 1605-1613 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
K. Tanahashi and A.G. Mikos, “Protein Adsorption and Smooth Muscle Cell Adhesion on Biodegradable Agmatine-Modified Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels,” J. Biomed. Mater. Res. Part A, 67A, 448-457 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
Z. Lalani, M. Wong, E.M. Brey, A.G. Mikos, and P.J. Duke, “Spatial and Temporal Localization of Transforming Growth Factor-b1, Bone Morphogenetic Protein-2, and Platelet-Derived Growth Factor-A in Healing Tooth Extraction Sockets in a Rabbit Model,” J. Oral Maxillofac. Surg., 61, 1061-1072 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
J.S. Temenoff, E.S. Steinbis, and A.G. Mikos, “Effect of Drying History on Swelling Properties and Cell Attachment to Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels for Guided Tissue Regeneration Applications,” J. Biomater. Sci., Polym. Ed., 14, 989-1004 (2003).

[Abstract Available on PubMed] [HTML]
J.P. Fisher, T.A. Holland, D. Dean, and A.G. Mikos, “Photoinitiated Crosslinking of the Biodegradable Polyester Poly(Propylene Fumarate). Part II: In Vitro Degradation,” Biomacromolecules, 4, 1335-1342 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
J.P. Fisher, M.D. Timmer, T.A. Holland, D. Dean, P.S. Engel, and A.G. Mikos, “Photoinitiated Cross-Linking of the Biodegradable Polyester Poly(Propylene Fumarate). Part I: Determination of Network Structure,” Biomacromolecules, 4, 1327-1334 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
M.D. Timmer, C. Carter, C.G. Ambrose, and A.G. Mikos, “Fabrication of Poly(Propylene Fumarate)-Based Orthopaedic Implants by Photo-Crosslinking Through Transparent Silicone Molds,” Biomaterials, 24, 4707-4714 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
M.E. Gomes, V.I. Sikavitsas, E. Behravesh, R.L. Reis, and A.G. Mikos, “Effect of Flow Perfusion on the Osteogenic Differentiation of Bone Marrow Stromal Cells Cultured on Starch-Based Three-Dimensional Scaffolds,” J.Biomed. Mater. Res. Part A, 67A, 87-95 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
T.A. Holland, Y. Tabata, and A.G. Mikos, “In Vitro Release of Transforming Growth Factor-b1 from Gelatin Microparticles Encapsulated in Biodegradable, Injectable Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels,” J. Controlled Release, 91, 299-313 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
P.Q. Ruhe, E.L. Hedberg, N.T. Padron, P.H. Spauwen, J.A. Jansen , and Mikos AG, “rhBMP-2 release from injectable poly(DL-lactic-co-glycolic acid)/calcium-phosphate cement composites,” J. Bone Joint Surg. Am., 85-A Suppl 3, 75-81 (2003).

[Abstract Available on PubMed]
J.K. Tessmar, A.G. Mikos, and A. Goepferich, “The Use of Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Derived Copolymers for the Rapid Creation of Biomimetic Surfaces,” Biomaterials, 24, 4475-4486 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
E. Behravesh, V.I. Sikavitsas, and A.G. Mikos, “Quantification of Ligand Surface Concentration of Bulk-Modified Biomimetic Hydrogels,” Biomaterials, 24, 4365-4374 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
H. Shin, S. Jo, and A.G. Mikos, “Biomimetic Materials for Tissue Engineering,” Biomaterials, 24, 4353-4364 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
M.D. Timmer, C.G. Ambrose, and A.G. Mikos, “Evaluation of Thermal- and Photo-Crosslinked Biodegradable Poly(Propylene Fumarate)-Based Networks,” J. Biomed. Mater. Res. Part A, 66A, 811-818 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
E. Behravesh and A.G. Mikos, “Three-Dimensional Culture of Differentiating Marrow Stromal Osteoblasts in Biomimetic Poly(Propylene Fumarate-co-Ethylene Glycol)-Based Macroporous Hydrogels,” J. Biomed. Mater. Res. Part A, 66A, 698-706 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
M.D. Timmer, H. Shin, R.A. Horch, C.G. Ambrose, and A.G. Mikos, “In Vitro Cytotoxicity of Injectable and Biodegradable Poly(Propylene Fumarate)-Based Networks: Unreacted Macromers, Cross-Linked Networks, and Degradation Products,” Biomacromolecules, 4, 1026-1033 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
D. Dean, N.S. Topham, S.C. Meneghetti, M.S. Wolfe, K. Jepsen, S. He, J.E.-K. Chen, J.P. Fisher, M. Cooke, C. Rimnac, and A.G. Mikos, “Poly(Propylene Fumarate) and Poly(DL-Lactic-co-Glycolic Acid) as Scaffold Materials for Solid and Foam-Coated Composite Tissue-Engineered Constructs for Cranial Reconstruction,” Tissue Eng., 9, 495-504 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
J. van den Dolder, G.N. Bancroft, V.I. Sikavitsas, P.H.M. Spauwen, A.G. Mikos, and J.A. Jansen, “Effect of Fibronectin- and Collagen I-Coated Titanium Fiber Mesh on Proliferation and Differentiation of Osteogenic Cells,” Tissue Eng., 9, 505-515 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
G.N. Bancroft, V.I. Sikavitsas, and A.G. Mikos, “Design of a Flow Perfusion Bioreactor System for Bone Tissue-Engineering Applications,” Tissue Eng., 9, 549-554 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
H. Shin, Q. Ruhé, A.G. Mikos, and J.A. Jansen, “In vivo bone and soft tissue response to injectable, biodegradable oligo(poly(ethylene glycol) fumarate) hydrogels,” Biomaterials, 24, 3201-3211 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
M.D. Timmer, R.A. Horch, C.G. Ambrose, and A.G. Mikos, “Effect of Physiological Temperature on the Mechanical Properties and Network Structure of Biodegradable Poly(Propylene Fumarate)-Based Networks,” J. Biomater. Sci., Polym. Ed., 14, 369-382 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
H. Shin, J.S. Temenoff, and A.G. Mikos, “In Vitro Cytotoxicity of Unsaturated Oligo(Poly(Ethylene Glycol) Fumarate) Macromers and their Crosslinked Hydrogels,” Biomacromolecules, 4, 552-560 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
A.K. Shung, E. Behravesh, S. Jo, and A.G. Mikos, “Crosslinking Characteristics of and Cell Adhesion to an Injectable Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogel Using a Water-Soluble Crosslinking System,” Tissue Eng., 9, 243-254 (2003)

[Abstract Available on PubMed] [PDF] [HTML]
E. Behravesh, K. Zygourakis, and A.G. Mikos, “Adhesion and Migration of Marrow-Derived Osteoblasts on Injectable In Situ Crosslinkable Poly(Propylene Fumarate-Co-Ethylene Glycol) Based Hydrogels with a Covalently Linked RGDS Peptide,” J. Biomed. Mater. Res. Part A, 65A, 261-271 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
E. Lieb, J. Tessmar, M. Hacker, C. Fischbach, D. Rose, T. Blunk, A.G. Mikos, A. Göpferich, and M.B. Schulz, “Poly(D,L-Lactic Acid)-Poly(Ethylene Glycol)-Monomethyl Ether Diblock Copolymers Control Adhesion and Osteoblastic Differentiation of Marrow Stromal Cells,” Tissue Eng., 9, 71-84 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
J. van den Dolder, G.N. Bancroft, V.I. Sikavitsas, P.H.M. Spauwen, J.A. Jansen, and A.G. Mikos, “Flow Perfusion Culture of Marrow Stromal Osteoblasts in Titanium Fiber Mesh,” J. Biomed. Mater. Res. Part A, 64A, 235-241 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
M.N. Cooke, J.P. Fisher, D. Dean, C. Rimnac, and A.G. Mikos, “Use of Stereoliphography to Manufacture Critical-Sized 3D Biodegradable Scaffolds for Bone Ingrowth,” J. Biomed. Mater. Res. Part B: Appl. Biomater., 64B, 65-69 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
T.A. Holland and A.G. Mikos, “Advances in Drug Delivery for Articular Cartilage,” J. Controlled Release, 86, 1-14 (2003).

[Abstract Available on PubMed] [PDF] [HTML]
M.D. Timmer, C.G. Ambrose, and A.G. Mikos, “In Vitro Degradation of Polymeric Networks of Poly(Propylene Fumarate) and the Crosslinking Macromer Poly(Propylene Fumarate)-Diacrylate,” Biomaterials, 24, 571-577 (2003).

[Abstract Available on PubMed] [PDF] [HTML]

2002

E.L. Hedberg, A. Tang, R.S. Crowther, D.H. Carney, and A.G. Mikos, “Controlled Release of an Osteogenic Peptide from Injectable Biodegradable Polymeric Composites,” J. Controlled Release, 84, 137-150 (2002).

[Abstract Available on PubMed] [PDF] [HTML]
E. Behravesh, M.D. Timmer, J.J. Lemoine, M.A.K. Liebschner, and A.G. Mikos, “Evaluation of the In Vitro Degradation of Macroporous Hydrogels Using Gravimetry, Confined Compression Testing, and Microcomputed Tomography,” Biomacromolecules, 3, 1263-1270 (2002).

[Abstract Available on PubMed] [PDF] [HTML]
G.N. Bancroft, V.I. Sikavitsas, J. van den Dolder, T.L. Sheffield, C.G. Ambrose, J.A. Jansen, and A.G. Mikos, “Fluid Flow Increases Mineralized Matrix Deposition in 3D Perfusion Culture of Marrow Stromal Osteoblasts in a Dose-Dependent Manner,” Proceed. Natl. Acad. Sci. USA, 99, 12600-12605 (2002).

[Abstract Available on PubMed] [PDF] [HTML]
K. Tanahashi, S. Jo, and A.G. Mikos, “Synthesis and Characterization of Biodegradable Cationic Poly(Propylene Fumarate-co-Ethylene Glycol) Copolymer Hydrogels Modified with Agmatine for Enhanced Cell Adhesion,” Biomacromolecules, 3, 1030-1037 (2002).

[Abstract Available on PubMed] [PDF] [HTML]
E.L. Chaikof, H. Matthew, J. Kohn, A.G. Mikos, G.D. Prestwich, and C.M. Yip, “Biomaterials and Scaffolds in Reparative Medicine,” Ann. N.Y. Acad. Sci., 961, 96-105 (2002).

[Abstract Available on PubMed] [PDF] [HTML]
E.L. Chaikof, H. Matthew, J. Kohn, G.D. Prestwich, A.G. Mikos, and C.M. Yip, “Bioscaffolds for Tissue Repair,” Ann. N.Y. Acad. Sci., 961, 112-113 (2002).

[Abstract Available on PubMed] [PDF] [HTML]
K. Tanahashi and A.G. Mikos, “Cell Adhesion on Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels,” J. Biomed. Mater. Res., 62, 558-566 (2002).

[Abstract Available on PubMed] [PDF] [HTML]
R.G. Payne, M.J. Yaszemski, A.W. Yasko, and A.G. Mikos, “Development of an Injectable, In Situ Crosslinkable, Degradable Polymeric Carrier for Osteogenic Cell Populations. Part 1. Encapsulation of Marrow Stromal Osteoblasts in Surface Crosslinked Gelatin Microparticles,” Biomaterials, 23, 4359-4371 (2002).

[Abstract Available on PubMed] [HTML] [PDF]
R.G. Payne, J.S. McGonigle, M.J. Yaszemski, A.W. Yasko, and A.G. Mikos, “Development of an Injectable, In Situ Crosslinkable, Degradable Polymeric Carrier for Osteogenic Populations. Part 2. Viability of Encapsulated Marrow Stromal Osteoblasts Cultured on Crosslinking Poly(Propylene Fumarate),” Biomaterials, 23, 4373-4380 (2002).

[Abstract Available on PubMed] [HTML] [PDF]
R.G. Payne, J.S. McGonigle, M.J. Yaszemski, A.W. Yasko, and A.G. Mikos, “Development of an Injectable, In Situ Crosslinkable, Degradable Polymeric Carrier for Osteogenic Populations. Part 3. Proliferation and Differentiation of Encapsulated Marrow Stromal Osteoblasts Cultured on Crosslinking Poly(Propylene Fumarate)” Biomaterials, 23, 4381-4387 (2002).

[Abstract Available on PubMed] [HTML] [PDF]
J.P. Fisher, D. Dean, and A.G. Mikos, “Photocrosslinking Characteristics and Mechanical Properties of Diethyl Fumarate/Poly(Propylene Fumarate) Biomaterials, Biomaterials, 23, 4333-4343 (2002).

[Abstract Available on PubMed] [HTML] [PDF]
V.I. Sikavitsas, G.N. Bancroft, and A.G. Mikos, “Formation of Three-Dimensional Cell/Polymer Constructs for Bone Tissue Engineering in a Spinner Flask and a Rotating Wall Vessel Bioreactor,” J. Biomed. Mater. Res., 62, 136-148 (2002).

[Abstract Available PubMed] [HTML] [PDF]
G.R.D. Evans, K. Brandt, S. Katz, P. Chauvin, L. Otto, M. Bogle, B. Wang, R.K. Meszlenyi, L. Lu, A.G. Mikos, and C.W. Patrick, Jr., “Bioactive Poly(L-Lactic Acid) Conduits Seeded with Schwann Cells for Peripheral Nerve Regeneration,” Biomaterials, 23, 841-848 (2002).

[Abstract Available on PubMed] [HTML] [PDF]
A.K. Shung, M.D. Timmer, S. Jo, P.S. Engel, and A.G. Mikos, “Kinetics of Poly(Propylene Fumarate) Synthesis by Step Polymerization of Diethyl Fumarate and Propylene Glycol Using Zinc Chloride as a Catalyst,” J. Biomater. Sci., Polym. Ed., 13, 95-108 (2002).

[Abstract Available on PubMed] [PDF]
M.S. Wolfe, D. Dean, J.E. Chen, J.P. Fisher, S. Han, C.M. Rimnac, and A.G. Mikos, “In Vitro Degradation and Fracture Toughness of Multilayered Porous Poly(Propylene Fumarate)/b-Tricalcium Phosphate Scaffolds,” J. Biomed. Mater. Res., 61, 159-164 (2002).

[Abstract Available on PubMed] [PDF] [HTML]
H. Shin, S. Jo, and A.G. Mikos, “Modulation of Marrow Stromal Osteoblast Adhesion on Biomimetic Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels Modified with Arg-Gly-Asp Peptides and a Poly(Ethylene Glycol) Spacer,” J. Biomed. Mater. Res., 61, 169-179 (2002).

[Abstract Available on PubMed] [PDF] [HTML]
M.D. Timmer, S. Jo, C. Wang, C.G. Ambrose, and A.G. Mikos, “Characterization of the Cross-Linked Structure of Fumarate-Based Degradable Polymer Networks,” Macromolecules, 35, 4373-4379 (2002).

[PDF] [HTML]
E. Behravesh, S. Jo, K. Zygourakis, and A.G. Mikos, “Synthesis of In Situ Crosslinkable Macroporous Biodegradable Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels,” Biomacromolecules, 3, 374-381 (2002).

[Abstract Available on PubMed] [PDF]
E. Behravesh, A.K. Shung, S. Jo, and A.G. Mikos, “Synthesis and Characterization of Triblock Copolymers of Methoxy Poly(Ethylene Glycol) and Poly(Propylene Fumarate),” Biomacromolecules, 3, 153-158 (2002).

[Abstract Available on PubMed] [PDF]
J.W.M. Vehof, J.P. Fisher, D. Dean, J.-P.C.M. van der Waerden, P.H.M. Spauwen, A.G. Mikos, and J.A. Jansen, “Bone Formation in Transforming Growth Factor b-1-Coated Porous Poly(Propylene Fumarate) Scaffolds,” J. Biomed. Mater. Res., 60, 241-251 (2002).

[Abstract Available on PubMed] [PDF] [HTML]
J.K. Tessmar, A.G. Mikos, and A. Goepferich, “Amine-Reactive Biodegradable Diblock Copolymers,” Biomacromolecules, 3, 194-200 (2002).

[Abstract Available on PubMed] [PDF]
J.P. Fisher, J.W.M. Vehof, D. Dean, J.P.C.M. van der Waerden, T.A. Holland, A.G. Mikos, and J.A. Jansen, “Soft and Hard Tissue Response to Photocrosslinked Poly(Propylene Fumarate) Scaffolds in a Rabbit Model,” J. Biomed. Mater. Res., 59, 547-556 (2002).

[Abstract Available on PubMed] [PDF] [HTML]
J.S. Temenoff, K.A. Athanasiou, R.G. LeBaron, and A.G. Mikos, “Effect of Poly(Ethylene Glycol) Molecular Weight on Tensile and Swelling Properties of Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels for Cartilage Tissue Engineering,” J. Biomed. Mater. Res., 59, 429-437 (2002).

[Abstract Available on PubMed] [PDF] [HTML]

2001

L. Lu, M.J. Yaszemski, and A.G. Mikos, “Retinal Pigment Epithelium Engineering Using Synthetic Biodegradable Polymers,” Biomaterials, 22, 3345-3355 (2001).

[Abstract Available on PubMed] [PDF]
J.P. Fisher, D. Dean, P.S. Engel, and A.G. Mikos, “Photoinitiated Polymerization of Biomaterials,” Ann. Rev. Mater. Res., 31, 171-181 (2001).

[PDF] [HTML]
V.I. Sikavitsas, J.S. Temenoff, and A.G. Mikos, “Biomaterials and Bone Mechanotransduction,” Biomaterials, 22, 2581-2593 (2001).

[Abstract Available on PubMed] [PDF]
J.P. Fisher, T.A. Holland, D. Dean, P.S. Engel, and A.G. Mikos, “Synthesis and Properties of Photocross-linked Poly(Propylene Fumarate) Scaffolds,” J. Biomater. Sci., Polym. Ed., 12, 673-687 (2001).

[Abstract Available on PubMed] [PDF]
G. Liu, S.G. Eskin, and A.G. Mikos, “Integrin avb3 Is Involved in Stimulated Migration of Vascular Adventitial Fibroblasts by Basic Fibroblast Growth Factor but not Platelet-Derived Growth Factor,” J. Cell. Biochem., 83, 129-135 (2001).

[Abstract Available on PubMed] [PDF] [HTML]
W.T. Godbey and A.G. Mikos, “Recent Progress in Gene Delivery Using Non-Viral Transfer Complexes,” J. Controlled Release, 72, 115-125 (2001).

[Abstract Available on PubMed] [PDF]
L. Lu, M.J. Yaszemski, and A.G. Mikos, “TGF-b1 Release from Biodegradable Polymer Microparticles: Its Effects on Marrow Stromal Osteoblast Function,” J. Bone Joint Surg., 83-A (Suppl. 1), 82-91 (2001).

[Abstract Available on PubMed] [PDF]
S. Jo, H. Shin, A.K. Shung, J.P. Fisher, and A.G. Mikos, “Synthesis and Characterization of Oligo(Poly(Ethylene Glycol) Fumarate) Macromer,” Macromolecules, 34, 2839-2844 (2001).

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A.S. Goldstein, T.M. Juarez, C.D. Helmke, M.C. Gustin, and A.G. Mikos, “Effect of Convection on Osteoblastic Cell Growth and Function in Biodegradable Polymer Foam Scaffolds,” Biomaterials, 22, 1279-1288 (2001).

[Abstract Available on PubMed] [PDF]
S. Jo, H. Shin, and A.G. Mikos, “Modification of Oligo(Poly(Ethylene Glycol) Fumarate) Macromer with GRGD Peptide for the Preparation of Functionalized Polymer Networks,” Biomacromolecules, 2, 255-261 (2001).

[Abstract Available on PubMed] [PDF] [HTML]
W.T. Godbey, K.K. Wu, and A.G. Mikos, “Poly(Ethylenimine)-Mediated Gene Delivery Affects Endothelial Cell Function and Viability,” Biomaterials, 22, 471-480 (2001).

[Abstract Available on PubMed] [PDF]
J.S. Blum, R.H. Li, A.G. Mikos, and M.A. Barry, “An Optimized Method for the Chemiluminescent Detection of Alkaline Phosphatase Levels during Osteodifferentiation by Bone Morphogenetic Protein 2,” J. Cell. Biochem., 80, 532-537 (2001).

[Abstract Available on PubMed] [PDF] [HTML]
L. Lu, K. Nyalakonda, L. Kam, R. Bizios, A. Göpferich, and A.G. Mikos, “Retinal Pigment Epithelial Cell Adhesion on Novel Micropatterned Surfaces Fabricated from Synthetic Biodegradable Polymers,” Biomaterials, 22, 291-297 (2001).

[Abstract Available on PubMed] [PDF]
S. He, M.D. Timmer, M.J. Yaszemski, A.W. Yasko, P.S. Engel, and A.G. Mikos, “Synthesis of Biodegradable Poly(Propylene Fumarate) Networks with Poly(Propylene Fumarate)-Diacrylate Macromers as Crosslinking Agents and Characterization of Their Degradation Products,” Polymer, 42, 1251-1260 (2001).

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2000

J.B. Oldham, L. Lu, X. Zhu, B.D. Porter, T.E. Hefferan, D.R. Larson, B.L. Currier, A.G. Mikos, and M.J. Yaszemski, “Biological Activity of rhBMP-2 Released from PLGA Microspheres,” J. Biomech. Eng., 122, 289-292 (2000).

[Abstract Available on PubMed] [HTML] [PDF] [PS]
B.D. Porter, J.B. Oldham, S.-L. He, M.E. Zobitz, R.G. Payne, K.N. An, B.L. Currier, A.G. Mikos, and M.J. Yaszemski, “Mechanical Properties of a Biodegradable Bone Regeneration Scaffold,” J. Biomech. Eng., 122, 286-288 (2000).

[Abstract Available on PubMed] [HTML] [PDF] [PS]
J.S. Temenoff and A.G. Mikos, “Injectable Biodegradable Materials for Orthopaedic Tissue Engineering,” Biomaterials, 21, 2405-2412 (2000).

[Abstract Available on PubMed] [PDF]
S. He, M.J. Yaszemski, A.W. Yasko, P.S. Engel, and A.G. Mikos, “Injectable Biodegradable Polymer Composites Based on Poly(Propylene Fumarate) Crosslinked with Poly(Ethylene Glycol)-Dimethacrylate,” Biomaterials, 21, 2389-2394 (2000).

[Abstract Available on PubMed] [PDF]
Q. Liu, E.L. Hedberg, Z. Liu, R. Bahulekar, R.K. Meszlenyi, and A.G. Mikos, “Preparation of Macroporous Poly(2-Hydroxyethyl Methacrylate) Hydrogels by Enhanced Phase Separation,” Biomaterials, 21, 2163-2169 (2000).

[Abstract Available on PubMed] [PDF]
L. Lu, S.J. Peter, M.D. Lyman, H.-L. Lai, S.M. Leite, J.A. Tamada, S. Uyama, J.P. Vacanti, R. Langer, and A.G. Mikos, “In Vitro and In Vivo Degradation of Porous Poly(DL-Lactic-co-Glycolic Acid) Foams,” Biomaterials, 21, 1837-1845 (2000).

[Abstract Available on PubMed] [PDF]
W.T. Godbey, M.A. Barry, P. Saggau, K.K. Wu, and A.G. Mikos, “Poly(Ethylenimine)-Mediated Transfection: A New Paradigm for Gene Delivery,” J. Biomed. Mater. Res., 51, 321-328 (2000).

[Abstract Available on PubMed] [PDF]
S. Jo, P.S. Engel, and A.G. Mikos, “Synthesis of Poly(Ethylene Glycol)-Tethered Poly(Propylene Fumarate) and Its Modification with GRGD Peptide,” Polymer, 41, 7595-7604 (2000).

J.E. Babensee, L.V. McIntire, and A.G. Mikos, “Growth Factor Delivery for Tissue Engineering,” Pharm. Res., 17, 497-504 (2000)

[Abstract Available on PubMed]
J.S. Temenoff and A.G. Mikos, “Formation of Highly Porous Biodegradable Scaffolds for Tissue Engineering,” Electronic J. Biotechnol., 3 (2) (2000)

[Available online]
L. Lu, S.J. Peter, M.D. Lyman, H.-L. Lai, S.M. Leite, J.A. Tamada, J.P. Vacanti, R. Langer, and A.G. Mikos, “In Vitro Degradation of Porous Poly(L-Lactic Acid) Foams,” Biomaterials, 21, 1595-1605 (2000).

[Abstract Available on PubMed] [PDF]
S.J. Peter, L. Lu, D.J. Kim, G.N. Stamatas, M.J. Miller, M.J. Yaszemski, and A.G. Mikos, “Effects of Transforming Growth Factor-b1 Released from Biodegradable Polymer Microparticles on Marrow Stromal Osteoblasts Cultured on Poly(Propylene Fumarate) Substrates,” J. Biomed. Mater. Res., 50, 452-462 (2000).

[Abstract Available on PubMed] [PDF]
L. Lu, G.N. Stamatas, and A.G. Mikos, “Controlled Release of Transforming Growth Factor-b1 from Biodegradable Polymer Microparticles,” J. Biomed. Mater. Res., 50, 440-451 (2000).

[Abstract Available on PubMed] [PDF]
S.J. Peter, L. Lu, D.J. Kim, and A.G. Mikos, “Marrow Stromal Osteoblast Function on a Poly(Propylene Fumarate)/b-Tricalcium Phosphate Biodegradable Orthopaedic Composite,” Biomaterials, 21, 1207-1213 (2000).

[Abstract Available on PubMed] [PDF]
J.S. Temenoff and A.G. Mikos, “Tissue Engineering for Regeneration of Articular Cartilage,” Biomaterials, 21, 431-440 (2000).

[Abstract Available on PubMed] [PDF]

2016

S.I. Simon, A.G. Mikos, and L.V. McIntire, “Fond Memories of our Mentor J. David Hellums, Annals of Biomedical Engineering,” Ann. Biomed. Eng., 44, 3157 (2016).

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M. Santoro, S.R. Shah, J.L. Walker, and A.G. Mikos, “Poly(Lactic Acid) Nanofibrous Scaffolds for Tissue Engineering,” Adv. Drug Deliv. Rev., 107, 206-212 (2016).

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A.M. Tatara, S.R. Shah, N. Demian, T. Ho, J. Shum, J.J.J.P. van den Beucken, J.A. Jansen, M.E. Wong, and A.G. Mikos, “Reconstruction of Large Mandibular Defects Using Autologous Tissues Generated from In Vivo Bioreactors,” Acta Biomaterialia, 45, 72-84 (2016).

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J.E. Trachtenberg, J.K. Placone, B.T. Smith, C.M. Piard, M. Santoro, D.W. Scott, J.P. Fisher, and A.G. Mikos, “Extrusion-Based 3D Printing of Poly(Propylene Fumarate) in a Full-Factorial Design,” ACS Biomater. Sci. Eng., 2, 1771-1780 (2016).

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S.-E. Lamhamedi-Cherradi, B.A. Menegaz, V. Ramamoorthy, D. Vishwamitra, Y. Wang, R.L. Maywald, A.S. Buford, I. Fokt, S. Skora, J. Wang, A. Naing, A.J. Lazar, E.M. Rohren, N.C. Daw, V. Subbiah, R.S. Benjamin, R. Ratan, W. Priebe, A.G. Mikos, H.M. Amin, and J.A. Ludwig, “IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma,” J. Natl. Cancer Inst., 108, djw182 (2016).

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S.R. Shah, S. Young, J.L. Goldman, J.A. Jansen, M.E. Wong, and A.G. Mikos, “A Composite Critical-Size Rabbit Mandibular Defect for Evaluation of Craniofacial Tissue Regeneration,” Nature Protocols, 11, 1989-2009 (2016).

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A.M. Tatara and A.G. Mikos, “Tissue Engineering in Orthopaedics,” J. Bone Joint Surg., 98, 1132-1139 (2016).

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A.M. Tatara, A.G. Mikos, and D.P. Kontoyiannis, “Factors Affecting Patient Outcome in Primary Cutaneous Aspergillosis,” Medicine, 95, e3747 (2016).

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T.N. Vo, Y. Tabata, and A.G. Mikos, “Effects of Cellular Parameters on the In Vitro Osteogenic Potential of Dual-Gelling Mesenchymal Stem Cell-Laden Hydrogels,” J. Biomater. Sci., Polym. Ed., 27, 1277-1290 (2016).

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S. Lu, E.J. Lee, J. Lam, Y. Tabata, and A.G. Mikos, “Evaluation of Gelatin Microparticles as Adherent-Substrates for Mesenchymal Stem Cells in a Hydrogel Composite,” Ann. Biomed. Eng., 44, 1894-1907 (2016).

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S.R. Shah, A.M. Tatara, J. Lam, S. Lu, D.W. Scott, G.N. Bennett, J.J.J.P. van den Beucken, J.A. Jansen, M.E. Wong, and A.G. Mikos, “Polymer-Based Local Antibiotic Delivery for Prevention of Polymicrobial Infection in Contaminated Mandibular Implants,” ACS Biomater. Sci. Eng., 2, 558-566 (2016).

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J. Lam, E.C. Clark, E.L.S. Fong, E.J. Lee, S. Lu, Y. Tabata, and A.G. Mikos, “Data Describing the Swelling Behavior and Cytocompatibility of Biodegradable Polyelectrolyte Hydrogels Incorporating Poly(L-Lysine) for Applications in Cartilage Tissue Engineering,” Data-in-Brief, 7, 614-619 (2016).

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J. Lam, E.C. Clark, E.L.S. Fong, E.J. Lee, S. Lu, Y. Tabata, and A.G. Mikos, “Evaluation of Cell-Laden Polyelectrolyte Hydrogels Incorporating Poly(L-Lysine) for Applications in Cartilage Tissue Engineering,” Biomaterials, 83, 332-346 (2016).

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T.N. Vo, S.R. Shah, S. Lu, A.M. Tatara, E.J. Lee, T.T. Roh, Y. Tabata, and A.G. Mikos, “Injectable Dual-Gelling Cell-Laden Composite Hydrogels for Bone Tissue Engineering,” Biomaterials, 83, 1-11 (2016).

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A.M. Tatara and A.G. Mikos, “2015 Lifetime Achievement Award of Tissue Engineering and Regenerative Medicine International Society-Americas: Antonios G. Mikos, PhD,” Tissue Eng. Part A, 22, 1-2 (2016).

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P.M. Mountziaris, S.R. Shah, J. Lam, G.N. Bennett, and A.G. Mikos, “A Rapid, Flexible Method for Incorporating Controlled Antibiotic Release into Porous Polymethylmethacrylate Space Maintainers for Craniofacial Reconstruction,” Biomater. Sci., 4, 121-129 (2016).

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E.L.S. Fong, X. Wan, J. Yang, M. Morgado, A.G. Mikos, D.A. Harrington, N.M. Navone, and M.C. Farach-Carson, “A 3D In Vitro Model of Patient-Derived Prostate Cancer Xenograft for Controlled Interrogation of In Vivo Tumor-Stromal Interactions,” Biomaterials, 77, 164-172 (2016).

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