Research Papers 2001-2010
2010
P.M. Mountziaris, S.N. Tzouanas, and A.G. Mikos, “Dose Effect of Tumor Necrosis Factor-α on In Vitro Osteogenic Differentiation of Mesenchymal Stem Cells on Biodegradable Polymeric Microfiber Scaffolds,” Biomaterials, 31, 1666-1675 (2010).
A.S. Mistry, Q.P. Pham, C. Schouten, T. Yeh, E.M. Christenson, A.G. Mikos, and J.A. Jansen, “In Vivo Bone Biocompatibility and Degradation of Porous Fumarate-Based Polymer/Alumoxane Nanocomposites for Bone Tissue Engineering,” J. Biomed. Mater. Res. Part A, 92A, 451-462 (2010).
X. Guo, H. Park, S. Young, J.D. Kretlow, J.J. van den Beucken, L.S. Baggett, Y. Tabata, F.K. Kasper, A.G. Mikos, and J.A. Jansen, “Repair of Osteochondral Defects with Biodegradable Hydrogel Composites Encapsulating Marrow Mesenchymal Stem Cells in a Rabbit Model,” Acta Biomaterialia, 6, 39-47 (2010).
R.A. Thibault, L.S. Baggett, A.G. Mikos, and F.K. Kasper, “Osteogenic Differentiation of Mesenchymal Stem Cells on Pregenerated Extracellular Matrix Scaffolds in the Absence of Osteogenic Cell Culture Supplements,” Tissue Eng. Part A, 16, 431-440 (2010).
A.M. Martins, C.M. Alves, F.K. Kasper, A.G. Mikos, and R.L. Reis, “Responsive and In Situ-Forming Chitosan Scaffolds for Bone Tissue Engineering Applications: An Overview of the Last Decade,” J. Mater. Chem., 20, 1638-1645 (2010).
S.A. Chew, M.C. Hacker, A. Saraf, R.M. Raphael, F.K. Kasper, and A.G. Mikos, “Altering Amine Basicities in Biodegradable Branched Polycationic Polymers for Nonviral Gene Delivery,” Biomacromolecules, 11, 600-609 (2010).
J.D. Kretlow, M.C. Hacker, L. Klouda, B.B. Ma, and A.G. Mikos, “Synthesis and Characterization of Dual Stimuli Responsive Macromers Based on Poly(N-Isopropylacrylamide) and Poly(Vinylphosphonic Acid),” Biomacromolecules, 11, 797-805 (2010).
M. Shi, J.D. Kretlow, A. Nguyen, S. Young, L.S. Baggett, M.E. Wong, F.K. Kasper, and A.G. Mikos, “Antibiotic-Releasing Porous Polymethylmethacrylate Constructs for Osseous Space Maintenance and Infection Control,” Biomaterials, 31, 4146-4156 (2010).
A. Saraf, L.S. Baggett, R.M. Raphael, F.K. Kasper, and A.G. Mikos, “Regulated Non-Viral Gene Delivery from Coaxial Electrospun Fiber Mesh Scaffolds,” J. Controlled Release, 143, 95-103 (2010).
M.W. Zhang, H. Park, X. Guo, K. Nakamura, R.M. Raphael, F.K. Kasper, A.G. Mikos, and P.A. Tsonis, “Adapting Biodegradable Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels for Pigment Epithelial Cell Encapsulation and Lens Regeneration,” Tissue Eng. Part C: Methods, 16, 261-267 (2010).
B. Sitharaman, M. van der Zande, J.S. Ananta, X. Shi, A. Veltien, X.F. Walboomers, L.J. Wilson, A.G. Mikos, A. Heerschap, and J.A. Jansen, “Magnetic Resonance Imaging Studies on Gadonanotube-Reinforced Biodegradable Polymer Nanocomposites,” J. Biomed. Mater. Res. Part A, 93A, 1454-1462 (2010).
W.J.E.M. Habraken, H.B. Liao, Z. Zhang, J.G.C. Wolke, D.W. Grijpma, A.G. Mikos, J. Feijen, and J.A. Jansen, “In Vivo Degradation of Calcium Phosphate Cement Incorporated into Biodegradable Microspheres,” Acta Biomaterialia, 6, 2200-2211 (2010).
J. Liao, X. Guo, D. Nelson, F.K. Kasper, and A.G. Mikos, “Modulation of Osteogenic Properties of Biodegradable Polymer/Extracellular Matrix Scaffolds Generated with a Flow Perfusion Bioreactor,” Acta Biomaterialia, 6, 2386-2393 (2010).
E. Burdett, F.K. Kasper, A.G. Mikos, and J.A. Ludwig, “Engineering Tumors: A Tissue Engineering Perspective in Cancer Biology,” Tissue Eng. Part B: Reviews, 16, 351-359 (2010).
X. Guo, J. Liao, H. Park, A. Saraf, R.M. Raphael, Y. Tabata, F.K. Kasper, and A.G. Mikos, “Effects of TGF-b3 and Preculture Period of Osteogenic Cells on the Chondrogenic Differentiation of Rabbit Marrow Mesenchymal Stem Cells Encapsulated in a Bilayered Hydrogel Composite,” Acta Biomaterialia, 6, 2920-2931 (2010).
A.M. Martins, A. Saraf, R.A. Sousa, C.M. Alves, A.G. Mikos, F.K. Kasper, and R.L. Reis, “Combination of Enzymes and Flow Perfusion Conditions Improves Osteogenic Differentiation of Bone Marrow Stromal Cells Cultured upon Starch/Poly(ε-Caprolactone) Fiber Meshes,” J. Biomed. Mater. Res. Part A, 94A, 1061-1069 (2010).
S.I. Ranganathan, D.M. Yoon, A.M. Henslee, M.B. Nair, C. Smid, F.K. Kasper, E. Tasciotti, A.G. Mikos, P. Decuzzi, and M. Ferrari, “Shaping the Micromechanical Behavior of Multi-Phase Composites for Bone Tissue Engineering,” Acta Biomaterialia, 6, 3448-3456 (2010).
P.M. Mountziaris, D.C. Sing, A.G. Mikos, and P.R. Kramer, “Intra-Articular Microparticles for Drug Delivery to the TMJ,” J. Dent. Res., 89, 1039-1044 (2010).
J. Liao, X. Guo, K.J. Grande-Allen, F.K. Kasper, and A.G. Mikos, “Bioactive Polymer/Extracellular Matrix Scaffolds Fabricated with a Flow Perfusion Bioreactor for Cartilage Tissue Engineering,” Biomaterials, 31, 8911-8920 (2010).
P.P. Spicer and A.G. Mikos, “Fibrin Glue as a Drug Delivery System,” J. Controlled Release, 148, 49-55 (2010).
J.D. Kretlow, M. Shi, S. Young, P.P. Spicer, N. Demian, J.A. Jansen, M.E. Wong, F.K. Kasper, and A.G. Mikos, “Evaluation of Soft Tissue Coverage over Porous Polymethylmethacrylate Space Maintainers within Nonhealing Alveolar Bone Defects,” Tissue Eng. Part C: Methods, 16, 1427-1438, 2010.
K. Gkioni, S.C.G. Leeuwenburgh, T.E.L. Douglas, A.G. Mikos, and J.A. Jansen, “Mineralization of Hydrogels for Bone Regeneration,” Tissue Eng. Part B: Reviews, 16, 577-585 (2010).
J.D. Kretlow, P.P. Spicer, J.A. Jansen, C.A. Vacanti, F.K. Kasper, and A.G. Mikos, “Uncultured Marrow Mononuclear Cells Delivered within Fibrin Glue Hydrogels to Porous Scaffolds Enhance Bone Regeneration within Critical-Sized Rat Cranial Defects,” Tissue Eng. Part A, 16, 3555-3568 (2010).
2009
A. Saraf, G. Lozier, A. Haesslein, F.K. Kasper, R.M. Raphael, L.S. Baggett, and A.G. Mikos, “Fabrication of Nonwoven Coaxial Fiber Meshes by Electrospinning,” Tissue Eng. Part C: Methods, 15, 333-344 (2009).
W.J.E.M. Habraken, J.G.C. Wolke, A.G. Mikos, and J.A. Jansen, “Porcine Gelatin Microsphere/Calcium Phosphate Cement Composites: An In Vitro Degradation Study,” J. Biomed. Mater. Res. Part B: Appl. Biomater., 91B, 555-561 (2009).
E.W.H. Bodde, W.J.E.M. Habraken, A.G. Mikos, P.H.M. Spauwen, and J.A. Jansen, “Effect of Polymer Molecular Weight on the Bone Biological Activity of Biodegradable Polymer/Calcium Phosphate Cement Composites,” Tissue Eng. Part A, 15, 3183-3191 (2009).
S.A. Chew, M.C. Hacker, A. Saraf, R.R. Raphael, F.K. Kasper, and A.G. Mikos, “Biodegradable Branched Polycationic Polymers with Varying Hydrophilic Spacers for Non-Viral Gene Delivery,” Biomacromolecules, 10, 2436-2445 (2009).
W.J.E.M. Habraken, O.C. Boerman, J.G.C. Wolke, A.G. Mikos, and J.A. Jansen, “In Vitro Growth Factor Release from Injectable Calcium Phosphate Cements Containing Gelatin Microspheres,” J. Biomed. Mater. Res. Part A, 91A, 614-622 (2009).
J.D. Kretlow, S. Young, L. Klouda, M. Wong, and A.G. Mikos, “Injectable Biomaterials for Regenerating Complex Craniofacial Tissues,” Adv. Mater., 21, 3368-3393 (2009).
S. Young, Z.S. Patel, J.D. Kretlow, M.B. Murphy, P.M. Mountziaris, L.S. Baggett, H. Ueda, Y. Tabata, J.A. Jansen, M. Wong, and A.G. Mikos, “Dose Effect of Dual Delivery of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein-2 on Bone Regeneration in a Rat Critical-Size Defect Model,” Tissue Eng. Part A, 15, 2347-2362 (2009).
L. Klouda, M.C. Hacker, J.D. Kretlow, and A.G. Mikos, “Cytocompatibility Evaluation of Amphiphilic, Thermally Responsive and Chemically Crosslinkable Macromers for In Situ Forming Hydrogels,” Biomaterials, 30, 4558-4566 (2009).
A.M. Martins, Q.P. Pham, P.B. Malafaya, R.M. Raphael, F.K. Kasper, R.L. Reis, and A.G. Mikos, “Natural Stimulus Responsive Scaffolds/Cells for Bone Tissue Engineering: Influence of Lysozyme upon Scaffold Degradation and Osteogenic Differentiation of Cultured Marrow Stromal Cells Induced by CaP Coatings,” Tissue Eng. Part A, 15, 1953-1963 (2009).
K. Kim, D. Dean, A.G. Mikos, and J.P. Fisher, “Effect of Initial Cell Seeding Density on Early Osteogenic Signal Expression of Rat Bone Marrow Stromal Cells Cultured on Cross-Linked Poly(Propylene Fumarate) Disks,” Biomacromolecules, 10, 1810-1817 (2009).
D.P. Link, J. van den Dolder, J.J.J.P. van den Beucken, W.J.E.M. Habraken, A. Soede, O.C. Boerman, A.G. Mikos, and J.A. Jansen, “Evaluation of an Orthotopically Implanted Calcium Phosphate Cement Containing Gelatin Microparticles,” J. Biomed. Mater. Res. Part A, 90A, 372-379 (2009).
F.K. Kasper, K. Tanahashi, J.P. Fisher, and A.G. Mikos, “Synthesis of Poly(Propylene Fumarate),” Nature Protocols, 4, 518-525 (2009).
X. Guo, H. Park, G. Liu, W. Liu, Y. Cao, Y. Tabata, F.K. Kasper, and A.G. Mikos, “In Vitro Generation of an Osteochondral Construct Using Injectable Hydrogel Composites Encapsulating Rabbit Marrow Mesenchymal Stem Cells,” Biomaterials, 30, 2741-2752 (2009).
A.S. Mistry, S.H. Cheng, T. Yeh, E.M. Christenson, J.A. Jansen, and A.G. Mikos, “Fabrication and In Vitro Degradation of Porous Fumarate-Based Polymer/Alumoxane Nanocomposite Scaffolds for Bone Tissue Engineering,” J. Biomed. Mater. Res. Part A, 89A, 68-79 (2009).
H. Park, X. Guo, J.S. Temenoff, Y. Tabata, A.I. Caplan, F.K. Kasper, and A.G. Mikos, “Effect of Swelling Ratio of Injectable Hydrogel Composites on Chondrogenic Differentiation of Encapsulated Rabbit Marrow Mesenchymal Stem Cells In Vitro,” Biomacromolecules, 10, 541-546 (2009).
L. Klouda and A.G. Mikos, “Biomaterials, Drug Delivery and Bionanotechnology – The Research that Paved the Way: Professor Nicholas Peppas’ Research Over the Years,” Pharm. Res., 26, 599-600 (2009).
M.C. Hacker, A. Haesslein, H. Ueda, W.J. Foster, C.A. Garcia, D.M. Ammon, R.N. Borazjani, J.F. Kunzler, J.C. Salamone, and A.G. Mikos, “Biodegradable Fumarate-Based Drug Delivery Systems for Ophthalmic Applications,” J. Biomed. Mater. Res. Part A, 88A, 976-989 (2009).
H. Park, J.S. Temenoff, Y. Tabata, A.I. Caplan, R.M. Raphael, J.A. Jansen, and A.G. Mikos, “Effect of Dual Growth Factor Delivery on Chondrogenic Differentiation of Rabbit Marrow Mesenchymal Stem Cells Encapsulated in Injectable Hydrogel Composites,” J. Biomed. Mater. Res. Part A, 88A, 889-897 (2009).
A.M. Martins, Q.P. Pham, P.B. Malafaya, R.A. Sousa, M.E. Gomes, R.M. Raphael, F.K. Kasper, R.L. Reis, and A.G. Mikos, “The Role of Lipase and a-Amylase in the Degradation of Starch/Poly(e-Caprolactone) Fiber Meshes and the Osteogenic Differentiation of Cultured Marrow Stromal Cells,” Tissue Eng. Part A, 15, 295-305 (2009).
P.M. Mountziaris, P.R. Kramer, and A.G. Mikos, “Emerging Intra-Articular Drug Delivery Systems for the Temporomandibular Joint,” Methods, 47, 134-140 (2009).
Q.P. Pham, F.K. Kasper, A.S. Mistry, U. Sharma, A.W. Yasko, J.A. Jansen, and A.G. Mikos, “Analysis of the Osteoinductive Capacity and Angiogenicity of an In Vitro Generated Extracellular Matrix,” J. Biomed. Mater. Res. Part A, 88A, 295-303 (2009).
A. Haesslein, M.C. Hacker, H. Ueda, D.M. Ammon, R.N. Borazjani, J.F. Kunzler, J.C. Salamone, and A.G. Mikos, “Matrix Modifications Modulate Ophthalmic Drug Delivery from Photo-Cross-Linked Poly(Propylene Fumarate)-Based Networks,” J. Biomater. Sci., Polym. Ed., 20, 49-69 (2009).
2008
J.D. Kretlow and A.G. Mikos, “From Material to Tissue: Biomaterial Development, Scaffold Fabrication, and Tissue Engineering,” AIChE J., 54, 3048-3067 (2008).
J.D. Kretlow, Y.-Q. Jin, W. Liu, W.J. Zhang, T.-H. Hong, G. Zhou, L.S. Baggett, A.G. Mikos, and Y. Cao, “Donor Age and Cell Passage Affect Differentiation Potential of Murine Bone Marrow-Derived Stem Cells,” BMC Cell Biology, 9, 60 (2008).
B. Sitharaman, T.Y. Zakharian, A. Saraf, P. Misra, J. Ashcroft, S. Pan, Q.P. Pham, A.G. Mikos, L.J. Wilson, and D.A. Engler, “Water-Soluble Fullerene (C60) Derivatives as Nonviral Gene-Delivery Vectors,” Mol. Pharmac., 5, 567-578 (2008).
W.J.E.M. Habraken, L.T. de Jonge, J.G.C. Wolke, L. Yubao, A.G. Mikos, and J.A. Jansen, “Introduction of Gelatin Microspheres into an Injectable Calcium Phosphate Cement,” J. Biomed. Mater. Res. Part A, 87A, 643-655 (2008).
E.W.H. Bodde, O.C. Boerman, F.G.M. Russel, A.G. Mikos, P.H.M. Spauwen, and J.A. Jansen, “The Kinetic and Biological Activity of Different Loaded rhBMP-2 Calcium Phosphate Cement Implants in Rats,” J. Biomed. Mater. Res. Part A, 87A, 780-791 (2008).
D.P. Link, J. van den Dolder, J.J.J.P. van den Beucken, V.M. Cuijpers, J.G.C. Wolke, A.G. Mikos, and J.A. Jansen, “Evaluation of the Biocompatibility of Calcium Phosphate Cement/PLGA Microparticle Composites,” J. Biomed. Mater. Res. Part A, 87A, 760-769 (2008).
Z.S. Patel, S. Young, Y. Tabata, J.A. Jansen, M.E.K. Wong, and A.G. Mikos, “Dual Delivery of an Angiogenic and an Osteogenic Growth Factor for Bone Regeneration in a Critical Size Defect Model,” Bone, 43, 931-940 (2008).
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E. Cosgriff-Hernandez and A.G. Mikos, “New Biomaterials as Scaffolds for Tissue Engineering,” Pharm. Res., 25, 2345-2347 (2008).
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Z.S. Patel, H. Ueda, M. Yamamoto, Y. Tabata, and A.G. Mikos, “In Vitro and In Vivo Release of Vascular Endothelial Growth Factor from Gelatin Microparticles and Biodegradable Composite Scaffolds,” Pharm. Res., 25, 2370-2378 (2008).
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J.P. Fisher, A.G. Mikos, P.C. Johnson, and J.A. Jansen, “A Continued Commitment to Quality Research in Tissue Engineering,” Tissue Eng. Part A, 14, 1457-1458 (2008).
S. Young, J.D. Kretlow, C. Nguyen, A.G. Bashoura, L.S. Baggett, J.A. Jansen, M. Wong, and A.G. Mikos, “Microcomputed Tomography Characterization of Neovascularization in Bone Tissue Engineering Applications,” Tissue Eng. Part B: Reviews, 14, 295-306 (2008).
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W.J.E.M. Habraken, J.G.C. Wolke, A.G. Mikos, and J.A. Jansen, “PLGA Microsphere/Calcium Phosphate Cement Composites for Tissue Engineering: In Vitro Release and Degradation Characteristics,” J. Biomater. Sci., Polym. Ed., 19, 1171-1188 (2008).
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Z.S. Patel, M. Yamamoto, H. Ueda, Y. Tabata, and A.G. Mikos, “Biodegradable Gelatin Microparticles as Delivery Systems for the Controlled Release of Bone Morphogenetic Protein-2,” Acta Biomaterialia, 4, 1126-1138 (2008).
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X. Shi, B. Sitharaman, Q.P. Pham, P.P. Spicer, J.L. Hudson, L.J. Wilson, J.M. Tour, R.M. Raphael, and A.G. Mikos, “In Vitro Cytotoxicity of Single-Walled Carbon Nanotube/Biodegradable Polymer Nanocomposites,” J. Biomed. Mater. Res. Part A, 86A, 813-823 (2008).
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B. Sitharaman, X. Shi, X.F. Walboomers, H. Liao, V. Cuijpers, L.J. Wilson, A.G. Mikos, and J.A. Jansen, “In Vivo Biocompatibility of Ultra-Short Single-Walled Carbon Nanotube/Biodegradable Polymer Nanocomposites for Bone Tissue Engineering,” Bone, 43, 362-370 (2008).
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P.M. Mountziaris and A.G. Mikos, “Modulation of the Inflammatory Response for Enhanced Bone Tissue Regeneration,” Tissue Eng. Part B: Reviews, 14, 179-186 (2008).
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M.C. Hacker, L. Klouda, B.B. Ma, J.D. Kretlow, and A.G. Mikos, “Synthesis and Characterization of Injectable, Thermally and Chemically Gelable, Amphiphilic Poly(N-Isopropylacrylamide)-Based Macromers,” Biomacromolecules, 9, 1558-1570 (2008).
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S. Young, A.G. Bashoura, T. Borden, L.S. Baggett, J.A. Jansen, M. Wong, and A.G. Mikos, “Development and Characterization of a Rabbit Alveolar Bone Nonhealing Defect Model,” J. Biomed. Mater. Res. Part A, 86A, 182-194 (2008).
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Q.P. Pham, F.K. Kasper, L.S. Baggett, R.M. Raphael, J.A. Jansen, and A.G. Mikos, “The Influence of an In Vitro Generated Bone-like Extracellular Matrix on Osteoblastic Gene Expression of Marrow Stromal Cells,” Biomaterials, 29, 2729-2739 (2008).
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J.A. Jansen, A.G. Mikos, and P.C. Johnson, “A New Focus on the Methods of Tissue Engineering,” Tissue Eng. Part C: Methods, 14, 1 (2008).
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W.J.E.M. Habraken, Z. Zhang, J.G.C. Wolke, D.W. Grijpma, A.G. Mikos, J. Feijen, and J.A. Jansen, “Introduction of Enzymatically Degradable Poly(Trimethylene Carbonate) Microspheres into an Injectable Calcium Phosphate Cement,” Biomaterials, 29, 2464-2476 (2008).
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J.P. Fisher, A.G. Mikos, and P.C. Johnson, “Tomorrow’s Tissue Engineering Triumphs Require Understanding of Today’s Achievements,” Tissue Eng. Part B: Reviews, 14, 1 (2008).
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A. Saraf, M.C. Hacker, B. Sitharaman, K.J. Grande-Allen, M.A. Barry, and A.G. Mikos, “Synthesis and Conformational Evaluation of a Novel Gene Delivery Vector for Human Mesenchymal Stem Cells,” Biomacromolecules, 9, 818-827 (2008).
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Y. Khan, M.J. Yaszemski, A.G. Mikos, and C. Laurencin, “Tissue Engineering of Bone: Material and Matrix Considerations,” J. Bone Joint Surg., 90, 36-42 (2008).
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E.W.H. Bodde, P.H.M. Spauwen, A.G. Mikos, and J.A. Jansen, “Closing Capacity of Segmental Radius Defects in Rabbits,” J. Biomed. Mater. Res. Part A, 85A, 206-217 (2008).
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D.P. Link, J. van den Dolder, J.J. van den Beucken, J.G. Wolke, A.G. Mikos, and J.A. Jansen, “Bone Response and Mechanical Strength of Rabbit Femoral Defects Filled with Injectable CaP Cements Containing TGF-β1 Loaded Gelatin Microparticles,” Biomaterials, 29, 675-682 (2008).
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L. Klouda and A.G. Mikos, “Thermoresponsive Hydrogels in Biomedical Applications ,” Eur. J. Pharm. Biopharm., 68, 34-45 (2008).
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A. Haesslein, M.C. Hacker, and A.G. Mikos, “Effects of Macromer Molecular Weight on In Vitro Opthalmic Drug Release from Photo-Crosslinked Matricies ,” Acta Biomater., 4, 1-10 (2008).
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2007
E.M. Christenson, W. Soofi, J.L. Holm, N.R. Cameron, and A.G. Mikos, “Biodegradable Fumarate-Based PolyHIPEs as Tissue Engineering Scaffolds,” Biomacromolecules, 8, 3806-3814 (2007).
P.C. Johnson, A.G. Mikos, J.P. Fisher, and J.A. Jansen, “Strategic Directions in Tissue Engineering,” Tissue Eng., 13, 2827-2837 (2007).
A.S. Mistry, A.G. Mikos, and J.A. Jansen, “Degradation and Biocompatibility of a Poly(Propylene Fumarate)-Based/Alumoxane Nanocomposite for Bone Tissue Engineering,” J. Biomed. Mater. Res. Part A, 83A, 940-953 (2007).
S. Kaihara, S. Matsumura, A.G. Mikos, and J.P. Fisher, “Synthesis of Poly(L-Lactide) and Polyglycolide by Ring-Opening Polymerization,” Nature Prot., 2, 2767-2771 (2007).
H. Ueda, M.C. Hacker, A. Haesslein, S. Jo, D.M. Ammon, R.N. Borazjani, J.F. Kunzler, J.C. Salamone, and A.G. Mikos, “Injectable, In Situ Forming Poly(Propylene Fumarate)-Based Ocular Drug Delivery Systems,” J. Biomed. Mater. Res. Part A, 83A, 656-666 (2007).
S.C.G. Leeuwenburgh, John A. Jansen, and A.G. Mikos, “Functionalization of Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels with Finely Dispersed Calcium Phosphate Nanocrystals for Bone-Substituting Purposes,” J. Biomater. Sci. Polym. Ed., 18, 1547-1564 (2007).
M.B. Murphy, J.D. Hartgerink, A. Goepferich, and A.G. Mikos, “Synthesis and In Vitro Hydroxyapatite Binding of Peptides Conjugated to Calcium-Binding Moieties,” Biomacromolecules, 8, 2237-2243 (2007).
X. Shi, B. Sitharaman, Q.P. Pham, F. Liang, K. Wu, W.E. Billups, L.J. Wilson, and A.G. Mikos, “Fabrication of Porous Ultra-Short Single-Walled Carbon Nanotube Nanocomposite Scaffolds for Bone Tissue Engineering,” Biomaterials, 28, 4078-4090 (2007).
B. Sitharaman, L.A. Tran, Q.P. Pham, R.D. Bolskar, R. Muthupillai, S.D. Flamm, A.G. Mikos, and L.J. Wilson, “Gadofullerenes as Nanoscale Magnetic Labels for Cellular MRI,” Contrast Media Mol. Imaging, 2, 139-146 (2007).
H. Castano-Izquierdo, J. Alvarez-Barreto, J. van den Dolder, J.A. Jansen, A.G. Mikos, and V.I. Sikavitsas, “Pre-Culture Period of Mesenchymal Stem Cells in Osteogenic Media Influences their In Vivo Bone Forming Potential,” J. Biomed. Mater. Res. Part A, 82A, 129-138 (2007).
J.M. Ashcroft, K.B. Hartman, K.R. Kissell, Y. Mackeyev, S. Pheasant, S. Young, P.A.W. Van der Heide, A.G. Mikos, and L.J. Wilson, “Single-Molecule I2@US-Tube Nanocapsules: A New X-Ray Contrast-Agent Design,” Adv. Mater., 19, 573-576 (2007).
J.D. Kretlow, L. Klouda, and A.G. Mikos, “Injectable Matrices and Scaffolds for Drug Delivery in Tissue Engineering,” Adv. Drug Deliv. Rev., 59, 263-273 (2007).
M. Hacker, M. Ringhofer, B. Appel, M. Neubauer, T. Vogel, S. Young, A.G. Mikos, T. Blunk, A. Göpferich, and M.B. Schulz, “Solid Lipid Templating of Macroporous Tissue Engineering Scaffolds,” Biomaterials, 28, 3497-3507 (2007).
B. Sitharaman, X. Shi, L.A. Tran, P.P. Spicer, I. Rusakova, L.J. Wilson, and A.G. Mikos, “Injectable In Situ Crosslinkable Nanocomposites of Biodegradable Polymers and Carbon Nanostructures for Bone Tissue Engineering,” J. Biomater. Sci., Polym. Ed., 18, 655-671 (2007).
J.D. Kretlow and A.G. Mikos, “Mineralization of Synthetic Polymer Scaffolds for Bone Tissue Engineering,” Tissue Eng., 13, 927-938 (2007).
H. Park, J.S. Temenoff, Y. Tabata, A.I. Caplan, and A.G. Mikos, “Injectable Biodegradable Hydrogel Composites for Rabbit Marrow Mesenchymal Stem Cell and Growth Factor Delivery for Cartilage Tissue Engineering,” Biomaterials, 28, 3217-3227 (2007).
T.A. Holland, E.W.H. Bodde, V.M.J.I. Cuijpers, L.S. Baggett, Y. Tabata, A.G. Mikos, and J.A. Jansen, “Degradable Hydrogel Scaffolds for In Vivo Evaluation of Growth Factor Interactions in Cartilage Repair,” Osteoarthritis Cartilage, 15, 187-197 (2007).
E.M. Christenson, K.S. Anseth, J.J.J.P. van den Beucken, C.K. Chan, B. Ercan, J.A. Jansen, C.T. Laurencin, W.-J. Li, R. Murugan, L.S. Nair, S. Ramakrishna, R.S. Tuan, T.J. Webster, and A.G. Mikos, “Nanobiomaterial Applications in Orthopaedics,” J. Orthop. Res., 25, 11-22 (2007).
2006
A.G. Mikos, S.W. Herring, P. Ochareon, J. Elisseeff, H.H. Lu, R. Kandel, F.J. Schoen, M. Toner, D. Mooney, A. Atala, M.E. van Dyke, D. Kaplan, and G. Vunjak-Novakovic, “Engineering Complex Tissues,” Tissue Eng., 12, 3307-3339 (2006).
M.E. Gomes, C.M. Bossano, C.M. Johnston, R.L. Reis, and A.G. Mikos, “In Vitro Localization of Bone Growth Factors in Constructs of Biodegradable Scaffolds Seeded with Marrow Stromal Cells and Cultured in a Flow Perfusion Bioreactor,” Tissue Eng., 12, 177-188 (2006).
2005
S. Young, M. Wong, Y. Tabata, and A.G. Mikos, “Gelatin as a Delivery Vehicle for the Controlled Release of Bioactive Molecules,” J. Controlled Release, 109, 256-274 (2005).
C.Y. Lin, R.M. Schek, A.S. Mistry, X. Shi, A.G. Mikos, P.H. Krebsbach, and S.J. Hollister, “Functional Bone Engineering Using ex Vivo Gene Therapy and Topology-Optimized, Biodegradable Polymer Composite Scaffolds,” Tissue Eng., 11, 1589-1598 (2005).
E.L. Hedberg, H.C. Kroese-Deutman, C.K. Shih, J.J. Lemoine, M.A. Liebschner, M.J. Miller, A.W. Yasko, R.S. Crowther, D.H. Carney, A.G. Mikos, and J.A. Jansen, “Methods: A Comparative Analysis of Radiography, Microcomputed Tomography, and Histology for Bone Tissue Engineering,” Tissue Eng., 11, 1356-1367 (2005).
Z. Lalani, M. Wong, E.M. Brey, A.G. Mikos, P.J. Duke, M.J. Miller, C. Johnston, and D. Montufar-Solis, “Spatial and Temporal Localization of FGF-2 and VEGF in Healing Tooth Extraction Sockets in a Rabbit Model,” J. Oral Maxillofac. Surg., 63, 1500-1508 (2005).
F.K. Kasper, T. Kushibiki, Y. Kimura, A.G. Mikos, and Y. Tabata, “In Vivo Release of Plasmid DNA from Composites of Oligo(Poly(Ethylene Glycol) Fumarate) and Cationized Gelatin Microspheres,” J. Controlled Release, 107, 547-561 (2005).
T.A. Holland, E.W.H. Bodde, L.S. Baggett, Y. Tabata, A.G. Mikos, and J.A. Jansen, “Osteochondral Repair in the Rabbit Model Utilizing Bilayered, Degradable Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogel Scaffolds,” J. Biomed. Mater. Res. Part A, 75A, 156-167 (2005).
P.Q. Ruhé, O.C. Boerman, F.G.M. Russel, P.H.M. Spauwen, A.G. Mikos, and J.A. Jansen, “Controlled Release of rhBMP-2 Loaded Poly(DL-Lactic-co-Glycolic Acid)/Calcium Phosphate Cement Composites In Vivo,” J. Controlled Release, 106, 162-171 (2005).
P.Q. Ruhé, E.L. Hedberg, N.T. Padron, P.H.M. Spauwen, J.A. Jansen, and A.G. Mikos, “Biocompatibility and Degradation of Poly(DL-Lactic-co-Glycolic Acid)/Calcium Phosphate Cement Composites,” J. Biomed. Mater. Res. Part A, 74A, 533-544 (2005).
H. Park, J.S. Temenoff, T.A. Holland, Y. Tabata, and A.G. Mikos, “Delivery of TGF-b1 and Chondrocytes via Injectable, Biodegradable Hydrogels for Cartilage Tissue Engineering Applications,” Biomaterials, 26, 7095-7103 (2005).
D. Dean, M.S. Wolfe, Y. Ahmad, A. Totonchi, J.E.-K. Chen, J.P. Fisher, M.N. Cooke, C.M. Rimnac, D.P. Lennon, A.I. Caplan, N.S. Topham, and A.G. Mikos, “Effect of Transforming Growth Factor b2 on Marrow-Infused Foam Poly(Propylene Fumarate) Tissue-Engineered Constructs for the Repair of Critical-Size Cranial Defects in Rabbits,” Tissue Eng., 11, 923-939 (2005).
H.L. Holtorf, T.L. Sheffield, C.G. Ambrose, J.A. Jansen, and A.G. Mikos, “Flow Perfusion Culture of Marrow Stromal Cells Seeded on Porous Biphasic Calcium Phosphate Ceramics,” Ann. Biomed. Eng., 33, 1238-1248 (2005).
H.L. Holtorf, N. Datta, J.A. Jansen, and A.G. Mikos, “Scaffold Mesh Size Affects the Osteoblastic Differentiation of Seeded Marrow Stromal Cells Cultured in a Flow Perfusion Bioreactor,” J. Biomed. Mater. Res. Part A, 74A, 171-180 (2005).
H.L. Holtorf, J.A. Jansen, and A.G. Mikos, “Ectopic Bone Formation in Rat Marrow Stromal Cell/Titanium Fiber Mesh Scaffold Constructs: Effect of Initial Cell Phenotype,” Biomaterials, 26, 6208-6216 (2005).
X. Shi, J.L. Hudson, P.P. Spicer, J.M. Tour, R. Krishnamoorti, and A.G. Mikos, “Rheological Behavior and Mechanical Characterization of Injectable Poly(Propylene Fumarate)/Single-Walled Carbon Nanotube Composites for Bone Tissue Engineering,” Nanotechnology, 16, S531-S538 (2005).
F.K. Kasper, S.K. Seidlits, A. Tang, R.S. Crowther, D.H. Carney, M.A. Barry, and A.G. Mikos, “In Vitro Release of Plasmid DNA from Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels,” J. Controlled Release, 104, 521-539 (2005).
A.S. Mistry and A.G. Mikos, “Tissue Engineering Strategies for Bone Regeneration,” Adv. Biochem. Eng. Biotechnol., 94, 1-22 (2005).
L.A. Solchaga, J.S. Temenoff, J. Gao, A.G. Mikos, A.I. Caplan, and V.M. Goldberg, “Repair of Osteochondral Defects with Hyaluronan- and Polyester-based Scaffolds,” Osteoarthritis Cartilage, 13, 297-309 (2005).
E.L. Hedberg, H.C. Kroese-Deutman, C.K. Shih, R.S. Crowther, D.H. Carney, A.G. Mikos, and J.A. Jansen, “In Vivo Degradation of Porous Poly(propylene fumarate)/Poly(DL-lactic-co-glycolic acid) Composite Scaffolds,” Biomaterials, 26, 4616-4623 (2005).
V.I. Sikavitsas, G.N. Bancroft, J.J. Lemoine, M.A. Liebschner, M. Dauner, and A.G. Mikos, “Flow Perfusion Enhances the Calcified Matrix Deposition of Marrow Stromal Cells in Biodegradable Nonwoven Fiber Mesh Scaffolds,” Ann. Biomed. Eng., 33, 63-70 (2005).
E.L. Hedberg, H.C. Kroese-Deutman, C.K. Shih, R.S. Crowther, D.H. Carney, A.G. Mikos, and J.A. Jansen, “Effect of Varied Release Kinetics of the Osteogenic Thrombin Peptide TP508 from Biodegradable, Polymeric Scaffolds on Bone Formation in Vivo,” J. Biomed. Mater. Res. Part A, 72A, 343-353 (2005).
H.L. Holtorf, J.A. Jansen, and A.G. Mikos, “Flow Perfusion Culture Induces the Osteoblastic Differentiation of Marrow Stromal Cell-Scaffold Constructs in the Absence of Dexamethasone,” J. Biomed. Mater. Res. Part A, 72A, 326-334 (2005).
H. Shin, J.S. Temenoff, G.C. Bowden, K. Zygourakis, M.C. Farach-Carson, M.J. Yaszemski, and A.G. Mikos, “Osteogenic Differentiation of Rat Bone Marrow Stromal Cells Cultured on Arg–Gly–Asp Modified Hydrogels Without Dexamethasone and β-Glycerol Phosphate,” Biomaterials, 26, 3645-3654 (2005).
E.L. Hedberg, C.K. Shih, J.J. Lemoine, M.D. Timmer, M.A. Liebschner, J.A. Jansen, and A.G. Mikos, “In Vitro Degradation of Porous Poly(propylene fumarate)/Poly(DL-lactic-co-glycolic acid) Composite Scaffolds,” Biomaterials, 26, 3215-3225 (2005).
J.A. Jansen, J.W.M. Vehof, P.Q. Ruhé, H. Kroeze-Deutman, Y. Kuboki, H. Takita, E.L. Hedberg, and A.G. Mikos, “Growth Factor-Laded Scaffolds for Bone Engineering,” J. Controlled Release, 101, 127-136 (2005).
T.A. Holland, Y. Tabata, and A.G. Mikos, “Dual Growth Factor Delivery from Degradable Oligo(poly(ethylene glycol) fumarate) Hydrogel Scaffolds for Cartilage Tissue Engineering,” J. Controlled Release, 101, 111-125 (2005).
N. Datta, H.L. Holtorf, V.I. Sikavitsas, J.A. Jansen, and A.G. Mikos, “Effect of Bone Extracellular Matrix Synthesized In Vitro on the Osteoblastic Differentiation of Marrow Stromal Cells,” Biomaterials, 26, 971-977 (2005).
2004
E.L. Hedberg, C.K. Shih, L.A. Solchaga, A.I. Caplan, and A.G. Mikos, “Controlled Release of Hyaluronan Oligomers from Biodegradable Polymeric Microparticle Carriers,” J. Control. Release, 100, 257-266 (2004).
J.P. Fisher, S. Jo, A.G. Mikos, and A.H. Reddi, “Thermoreversible Hydrogel Scaffolds for Articular Cartilage Engineering,” J. Biomed. Mater. Res., 71A, 268-274 (2004).
R.A. Horch, N. Shahid, A.S. Mistry, M.D. Timmer, A.G. Mikos, and A.R. Barron, “Nanoreinforcement of Poly(Propylene Fumarate)-Based Networks with Surface Modified Alumoxane Nanoparticles for Bone Tissue Engineering,” Biomacromolecules, 5, 1990-1998 (2004).
J.S. Blum, J.S. Temenoff, H. Park, J.A. Jansen, A.G. Mikos, and M.A. Barry, “Development and Characterization of Enhanced Green Fluorescent Protein and Luciferase Expressing Cell Line for Non-Destructive Evaluation of Tissue Engineering Constructs,” Biomaterials, 25, 5809-5819 (2004).
Z.S. Patel and A.G. Mikos, “Angiogenesis with Biomaterial-Based Drug- and Cell-Delivery Systems,” J. Biomater. Sci., Polym. Ed., 15, 701-726 (2004).
J.S. Temenoff, H. Park, E. Jabbari, T.L. Sheffield, R.G. LeBaron, C.G. Ambrose, and A.G. Mikos, “In Vitro Osteogenic Differentiation of Marrow Stromal Cells Encapsulated in Biodegradable Hydrogels,” J. Biomed. Mater. Res. Part A, 70A, 235-244 (2004).
H. Shin, K. Zygourakis, M.C. Farach-Carson, M.J. Yaszemski, and A.G. Mikos, “Modulation of Differentiation and Mineralization of Marrow Stromal Cells Cultured on Biomimetic Hydrogels Modified with Arg-Gly-Asp Containing Peptides,” J. Biomed. Mater. Res. Part A, 69A, 535-543 (2004).
C.G. Ambrose, T.A. Clyburn, K. Louden, J. Joseph, J. Wright, P. Gulati, G.R. Gogola, and A.G. Mikos, “Effective Treatment of Osteomyelitis with Biodegradable Microspheres in a Rabbit Model,” Clin. Orthop. Rel. Res., 421, 293-299 (2004).
Z. Lalani, M.E.K. Wong, E.M. Brey, A.G. Mikos, P.J. Duke, and C. Johnston, “Spatial and Temporal Localization of Secretory IgA in Healing Tooth Extraction Sockets in a Rabbit Model,” J. Oral Maxillofac. Surg., 62, 466-472 (2004).
J.S. Blum, M.B. Parrott, A.G. Mikos, and M.A. Barry, “Early Osteoblastic Differentiation Induced by Dexamethasone Enhances Adenoviral Gene Delivery to Marrow Stromal Cells,” J. Orthop. Res., 22, 411-416 (2004).
J.P. Fisher, Z. Lalani, C.M. Bossano, E.M. Brey, N. Demian, C.M. Johnston, D. Dean, J.A. Jansen, M.E.K. Wong, and A.G. Mikos, “Effect of Biomaterial Properties on Bone Healing in a Rabbit Tooth Extraction Socket Model,” J. Biomed. Mater. Res. Part A, 68A, 428-438 (2004).
J.S. Temenoff, H. Park, E. Jabbari, D.E. Conway, T.L. Sheffield, C.G. Ambrose, and A.G. Mikos, “Thermally Cross-Linked Oligo(poly(ethylene glycol) fumarate) Hydrogels Support Osteogenic Differentiation of Encapsulated Marrow Stromal Cells In Vitro,” Biomacromolecules, 5, 5-10 (2004).
T.A. Holland, J.K.V. Tessmar, Y. Tabata, and A.G. Mikos, “Transforming Growth Factor-b1 Release from Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels in Conditions Which Model the Cartilage Wound Healing Environment,” J. Controlled Release, 94, 101-114 (2004).
H. Shin, K. Zygourakis, M.C. Farach-Carson, M.J. Yaszemski, and A.G. Mikos, “Attachment, Proliferation, and Migration of Marrow Stromal Osteoblasts Cultured on Biomimetic Hydrogels Modified with an Osteopontin-Derived Peptide,” Biomaterials, 25, 895-906 (2004).
2003
V.I. Sikavitsas, G.N. Bancroft, H.L. Holtorf, J.A. Jansen, and A.G. Mikos, “Mineralized Matrix Deposition by Marrow Stromal Osteoblasts in 3D Perfusion Culture Increases with Increasing Fluid Shear Forces,” Proceed. Natl. Acad. Sci. USA, 100, 14683-14688 (2003).
J.S. Blum, M.A. Barry, A.G. Mikos, and J.A. Jansen, “In Vivo Evaluation of Gene Therapy Vectors in Ex Vivo Derived Marrow Stromal Cells for Bone Regeneration in a Rat Critical Size Calvarial Defect Model,” Human Gene Therapy, 14, 1689-1701 (2003).
C.G. Ambrose, G.R. Gogola, T.A. Clyburn, A.K. Raymond, A.S. Peng, and A.G. Mikos, “Antibiotic Microspheres: Preliminary Testing for Potential Treatment of Osteomyelitis,” Clin. Orthop. Rel. Res., 415, 279-285 (2003).
K. Tanahashi and A.G. Mikos, “Effect of Hydrophilicity and Agmatine Modification on Degradation of Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels,” J. Biomed. Mater. Res. Part A, 67A, 1148-1154 (2003).
J.S. Blum, M.A. Barry, and A.G. Mikos, “Bone Regeneration through Transplantation of Genetically Modified Cells,” Clin. Plast. Surg., 30, 611-620 (2003).
V.I. Sikavitsas, J. van den Dolder, G.N. Bancroft, P.H.M. Spauwen, J.A. Jansen, and A.G. Mikos, “Influence of the In Vitro Culture Period on the In Vivo Performance of Cell/Titanium Bone Tissue Engineered Constructs Using a Rat Cranial Critical Size Defect Model,” J. Biomed. Mater. Res. Part A, 67A, 944-951 (2003).
J.S. Temenoff, H. Shin, D.E. Conway, P.S. Engel, and A.G. Mikos, “In Vitro Cytotoxicity of Redox Radical Initiators for Crosslinking of Oligo(Poly(Ethylene Glycol) Fumarate) Macromers,” Biomacromolecules, 4, 1605-1613 (2003).
K. Tanahashi and A.G. Mikos, “Protein Adsorption and Smooth Muscle Cell Adhesion on Biodegradable Agmatine-Modified Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels,” J. Biomed. Mater. Res. Part A, 67A, 448-457 (2003).
Z. Lalani, M. Wong, E.M. Brey, A.G. Mikos, and P.J. Duke, “Spatial and Temporal Localization of Transforming Growth Factor-b1, Bone Morphogenetic Protein-2, and Platelet-Derived Growth Factor-A in Healing Tooth Extraction Sockets in a Rabbit Model,” J. Oral Maxillofac. Surg., 61, 1061-1072 (2003).
J.S. Temenoff, E.S. Steinbis, and A.G. Mikos, “Effect of Drying History on Swelling Properties and Cell Attachment to Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels for Guided Tissue Regeneration Applications,” J. Biomater. Sci., Polym. Ed., 14, 989-1004 (2003).
J.P. Fisher, T.A. Holland, D. Dean, and A.G. Mikos, “Photoinitiated Crosslinking of the Biodegradable Polyester Poly(Propylene Fumarate). Part II: In Vitro Degradation,” Biomacromolecules, 4, 1335-1342 (2003).
J.P. Fisher, M.D. Timmer, T.A. Holland, D. Dean, P.S. Engel, and A.G. Mikos, “Photoinitiated Cross-Linking of the Biodegradable Polyester Poly(Propylene Fumarate). Part I: Determination of Network Structure,” Biomacromolecules, 4, 1327-1334 (2003).
M.D. Timmer, C. Carter, C.G. Ambrose, and A.G. Mikos, “Fabrication of Poly(Propylene Fumarate)-Based Orthopaedic Implants by Photo-Crosslinking Through Transparent Silicone Molds,” Biomaterials, 24, 4707-4714 (2003).
M.E. Gomes, V.I. Sikavitsas, E. Behravesh, R.L. Reis, and A.G. Mikos, “Effect of Flow Perfusion on the Osteogenic Differentiation of Bone Marrow Stromal Cells Cultured on Starch-Based Three-Dimensional Scaffolds,” J.Biomed. Mater. Res. Part A, 67A, 87-95 (2003).
T.A. Holland, Y. Tabata, and A.G. Mikos, “In Vitro Release of Transforming Growth Factor-b1 from Gelatin Microparticles Encapsulated in Biodegradable, Injectable Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels,” J. Controlled Release, 91, 299-313 (2003).
P.Q. Ruhe, E.L. Hedberg, N.T. Padron, P.H. Spauwen, J.A. Jansen , and Mikos AG, “rhBMP-2 release from injectable poly(DL-lactic-co-glycolic acid)/calcium-phosphate cement composites,” J. Bone Joint Surg. Am., 85-A Suppl 3, 75-81 (2003).
J.K. Tessmar, A.G. Mikos, and A. Goepferich, “The Use of Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Derived Copolymers for the Rapid Creation of Biomimetic Surfaces,” Biomaterials, 24, 4475-4486 (2003).
E. Behravesh, V.I. Sikavitsas, and A.G. Mikos, “Quantification of Ligand Surface Concentration of Bulk-Modified Biomimetic Hydrogels,” Biomaterials, 24, 4365-4374 (2003).
H. Shin, S. Jo, and A.G. Mikos, “Biomimetic Materials for Tissue Engineering,” Biomaterials, 24, 4353-4364 (2003).
M.D. Timmer, C.G. Ambrose, and A.G. Mikos, “Evaluation of Thermal- and Photo-Crosslinked Biodegradable Poly(Propylene Fumarate)-Based Networks,” J. Biomed. Mater. Res. Part A, 66A, 811-818 (2003).
E. Behravesh and A.G. Mikos, “Three-Dimensional Culture of Differentiating Marrow Stromal Osteoblasts in Biomimetic Poly(Propylene Fumarate-co-Ethylene Glycol)-Based Macroporous Hydrogels,” J. Biomed. Mater. Res. Part A, 66A, 698-706 (2003).
M.D. Timmer, H. Shin, R.A. Horch, C.G. Ambrose, and A.G. Mikos, “In Vitro Cytotoxicity of Injectable and Biodegradable Poly(Propylene Fumarate)-Based Networks: Unreacted Macromers, Cross-Linked Networks, and Degradation Products,” Biomacromolecules, 4, 1026-1033 (2003).
D. Dean, N.S. Topham, S.C. Meneghetti, M.S. Wolfe, K. Jepsen, S. He, J.E.-K. Chen, J.P. Fisher, M. Cooke, C. Rimnac, and A.G. Mikos, “Poly(Propylene Fumarate) and Poly(DL-Lactic-co-Glycolic Acid) as Scaffold Materials for Solid and Foam-Coated Composite Tissue-Engineered Constructs for Cranial Reconstruction,” Tissue Eng., 9, 495-504 (2003).
J. van den Dolder, G.N. Bancroft, V.I. Sikavitsas, P.H.M. Spauwen, A.G. Mikos, and J.A. Jansen, “Effect of Fibronectin- and Collagen I-Coated Titanium Fiber Mesh on Proliferation and Differentiation of Osteogenic Cells,” Tissue Eng., 9, 505-515 (2003).
G.N. Bancroft, V.I. Sikavitsas, and A.G. Mikos, “Design of a Flow Perfusion Bioreactor System for Bone Tissue-Engineering Applications,” Tissue Eng., 9, 549-554 (2003).
H. Shin, Q. Ruhé, A.G. Mikos, and J.A. Jansen, “In vivo bone and soft tissue response to injectable, biodegradable oligo(poly(ethylene glycol) fumarate) hydrogels,” Biomaterials, 24, 3201-3211 (2003).
M.D. Timmer, R.A. Horch, C.G. Ambrose, and A.G. Mikos, “Effect of Physiological Temperature on the Mechanical Properties and Network Structure of Biodegradable Poly(Propylene Fumarate)-Based Networks,” J. Biomater. Sci., Polym. Ed., 14, 369-382 (2003).
H. Shin, J.S. Temenoff, and A.G. Mikos, “In Vitro Cytotoxicity of Unsaturated Oligo(Poly(Ethylene Glycol) Fumarate) Macromers and their Crosslinked Hydrogels,” Biomacromolecules, 4, 552-560 (2003).
A.K. Shung, E. Behravesh, S. Jo, and A.G. Mikos, “Crosslinking Characteristics of and Cell Adhesion to an Injectable Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogel Using a Water-Soluble Crosslinking System,” Tissue Eng., 9, 243-254 (2003)
E. Behravesh, K. Zygourakis, and A.G. Mikos, “Adhesion and Migration of Marrow-Derived Osteoblasts on Injectable In Situ Crosslinkable Poly(Propylene Fumarate-Co-Ethylene Glycol) Based Hydrogels with a Covalently Linked RGDS Peptide,” J. Biomed. Mater. Res. Part A, 65A, 261-271 (2003).
E. Lieb, J. Tessmar, M. Hacker, C. Fischbach, D. Rose, T. Blunk, A.G. Mikos, A. Göpferich, and M.B. Schulz, “Poly(D,L-Lactic Acid)-Poly(Ethylene Glycol)-Monomethyl Ether Diblock Copolymers Control Adhesion and Osteoblastic Differentiation of Marrow Stromal Cells,” Tissue Eng., 9, 71-84 (2003).
J. van den Dolder, G.N. Bancroft, V.I. Sikavitsas, P.H.M. Spauwen, J.A. Jansen, and A.G. Mikos, “Flow Perfusion Culture of Marrow Stromal Osteoblasts in Titanium Fiber Mesh,” J. Biomed. Mater. Res. Part A, 64A, 235-241 (2003).
M.N. Cooke, J.P. Fisher, D. Dean, C. Rimnac, and A.G. Mikos, “Use of Stereoliphography to Manufacture Critical-Sized 3D Biodegradable Scaffolds for Bone Ingrowth,” J. Biomed. Mater. Res. Part B: Appl. Biomater., 64B, 65-69 (2003).
T.A. Holland and A.G. Mikos, “Advances in Drug Delivery for Articular Cartilage,” J. Controlled Release, 86, 1-14 (2003).
M.D. Timmer, C.G. Ambrose, and A.G. Mikos, “In Vitro Degradation of Polymeric Networks of Poly(Propylene Fumarate) and the Crosslinking Macromer Poly(Propylene Fumarate)-Diacrylate,” Biomaterials, 24, 571-577 (2003).
2002
E.L. Hedberg, A. Tang, R.S. Crowther, D.H. Carney, and A.G. Mikos, “Controlled Release of an Osteogenic Peptide from Injectable Biodegradable Polymeric Composites,” J. Controlled Release, 84, 137-150 (2002).
E. Behravesh, M.D. Timmer, J.J. Lemoine, M.A.K. Liebschner, and A.G. Mikos, “Evaluation of the In Vitro Degradation of Macroporous Hydrogels Using Gravimetry, Confined Compression Testing, and Microcomputed Tomography,” Biomacromolecules, 3, 1263-1270 (2002).
G.N. Bancroft, V.I. Sikavitsas, J. van den Dolder, T.L. Sheffield, C.G. Ambrose, J.A. Jansen, and A.G. Mikos, “Fluid Flow Increases Mineralized Matrix Deposition in 3D Perfusion Culture of Marrow Stromal Osteoblasts in a Dose-Dependent Manner,” Proceed. Natl. Acad. Sci. USA, 99, 12600-12605 (2002).
K. Tanahashi, S. Jo, and A.G. Mikos, “Synthesis and Characterization of Biodegradable Cationic Poly(Propylene Fumarate-co-Ethylene Glycol) Copolymer Hydrogels Modified with Agmatine for Enhanced Cell Adhesion,” Biomacromolecules, 3, 1030-1037 (2002).
E.L. Chaikof, H. Matthew, J. Kohn, A.G. Mikos, G.D. Prestwich, and C.M. Yip, “Biomaterials and Scaffolds in Reparative Medicine,” Ann. N.Y. Acad. Sci., 961, 96-105 (2002).
E.L. Chaikof, H. Matthew, J. Kohn, G.D. Prestwich, A.G. Mikos, and C.M. Yip, “Bioscaffolds for Tissue Repair,” Ann. N.Y. Acad. Sci., 961, 112-113 (2002).
K. Tanahashi and A.G. Mikos, “Cell Adhesion on Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels,” J. Biomed. Mater. Res., 62, 558-566 (2002).
R.G. Payne, M.J. Yaszemski, A.W. Yasko, and A.G. Mikos, “Development of an Injectable, In Situ Crosslinkable, Degradable Polymeric Carrier for Osteogenic Cell Populations. Part 1. Encapsulation of Marrow Stromal Osteoblasts in Surface Crosslinked Gelatin Microparticles,” Biomaterials, 23, 4359-4371 (2002).
R.G. Payne, J.S. McGonigle, M.J. Yaszemski, A.W. Yasko, and A.G. Mikos, “Development of an Injectable, In Situ Crosslinkable, Degradable Polymeric Carrier for Osteogenic Populations. Part 2. Viability of Encapsulated Marrow Stromal Osteoblasts Cultured on Crosslinking Poly(Propylene Fumarate),” Biomaterials, 23, 4373-4380 (2002).
R.G. Payne, J.S. McGonigle, M.J. Yaszemski, A.W. Yasko, and A.G. Mikos, “Development of an Injectable, In Situ Crosslinkable, Degradable Polymeric Carrier for Osteogenic Populations. Part 3. Proliferation and Differentiation of Encapsulated Marrow Stromal Osteoblasts Cultured on Crosslinking Poly(Propylene Fumarate)” Biomaterials, 23, 4381-4387 (2002).
J.P. Fisher, D. Dean, and A.G. Mikos, “Photocrosslinking Characteristics and Mechanical Properties of Diethyl Fumarate/Poly(Propylene Fumarate) Biomaterials, Biomaterials, 23, 4333-4343 (2002).
V.I. Sikavitsas, G.N. Bancroft, and A.G. Mikos, “Formation of Three-Dimensional Cell/Polymer Constructs for Bone Tissue Engineering in a Spinner Flask and a Rotating Wall Vessel Bioreactor,” J. Biomed. Mater. Res., 62, 136-148 (2002).
G.R.D. Evans, K. Brandt, S. Katz, P. Chauvin, L. Otto, M. Bogle, B. Wang, R.K. Meszlenyi, L. Lu, A.G. Mikos, and C.W. Patrick, Jr., “Bioactive Poly(L-Lactic Acid) Conduits Seeded with Schwann Cells for Peripheral Nerve Regeneration,” Biomaterials, 23, 841-848 (2002).
A.K. Shung, M.D. Timmer, S. Jo, P.S. Engel, and A.G. Mikos, “Kinetics of Poly(Propylene Fumarate) Synthesis by Step Polymerization of Diethyl Fumarate and Propylene Glycol Using Zinc Chloride as a Catalyst,” J. Biomater. Sci., Polym. Ed., 13, 95-108 (2002).
M.S. Wolfe, D. Dean, J.E. Chen, J.P. Fisher, S. Han, C.M. Rimnac, and A.G. Mikos, “In Vitro Degradation and Fracture Toughness of Multilayered Porous Poly(Propylene Fumarate)/b-Tricalcium Phosphate Scaffolds,” J. Biomed. Mater. Res., 61, 159-164 (2002).
H. Shin, S. Jo, and A.G. Mikos, “Modulation of Marrow Stromal Osteoblast Adhesion on Biomimetic Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels Modified with Arg-Gly-Asp Peptides and a Poly(Ethylene Glycol) Spacer,” J. Biomed. Mater. Res., 61, 169-179 (2002).
M.D. Timmer, S. Jo, C. Wang, C.G. Ambrose, and A.G. Mikos, “Characterization of the Cross-Linked Structure of Fumarate-Based Degradable Polymer Networks,” Macromolecules, 35, 4373-4379 (2002).
E. Behravesh, S. Jo, K. Zygourakis, and A.G. Mikos, “Synthesis of In Situ Crosslinkable Macroporous Biodegradable Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels,” Biomacromolecules, 3, 374-381 (2002).
E. Behravesh, A.K. Shung, S. Jo, and A.G. Mikos, “Synthesis and Characterization of Triblock Copolymers of Methoxy Poly(Ethylene Glycol) and Poly(Propylene Fumarate),” Biomacromolecules, 3, 153-158 (2002).
J.W.M. Vehof, J.P. Fisher, D. Dean, J.-P.C.M. van der Waerden, P.H.M. Spauwen, A.G. Mikos, and J.A. Jansen, “Bone Formation in Transforming Growth Factor b-1-Coated Porous Poly(Propylene Fumarate) Scaffolds,” J. Biomed. Mater. Res., 60, 241-251 (2002).
J.K. Tessmar, A.G. Mikos, and A. Goepferich, “Amine-Reactive Biodegradable Diblock Copolymers,” Biomacromolecules, 3, 194-200 (2002).
J.P. Fisher, J.W.M. Vehof, D. Dean, J.P.C.M. van der Waerden, T.A. Holland, A.G. Mikos, and J.A. Jansen, “Soft and Hard Tissue Response to Photocrosslinked Poly(Propylene Fumarate) Scaffolds in a Rabbit Model,” J. Biomed. Mater. Res., 59, 547-556 (2002).
J.S. Temenoff, K.A. Athanasiou, R.G. LeBaron, and A.G. Mikos, “Effect of Poly(Ethylene Glycol) Molecular Weight on Tensile and Swelling Properties of Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels for Cartilage Tissue Engineering,” J. Biomed. Mater. Res., 59, 429-437 (2002).
2001
L. Lu, M.J. Yaszemski, and A.G. Mikos, “Retinal Pigment Epithelium Engineering Using Synthetic Biodegradable Polymers,” Biomaterials, 22, 3345-3355 (2001).
J.P. Fisher, D. Dean, P.S. Engel, and A.G. Mikos, “Photoinitiated Polymerization of Biomaterials,” Ann. Rev. Mater. Res., 31, 171-181 (2001).
V.I. Sikavitsas, J.S. Temenoff, and A.G. Mikos, “Biomaterials and Bone Mechanotransduction,” Biomaterials, 22, 2581-2593 (2001).
J.P. Fisher, T.A. Holland, D. Dean, P.S. Engel, and A.G. Mikos, “Synthesis and Properties of Photocross-linked Poly(Propylene Fumarate) Scaffolds,” J. Biomater. Sci., Polym. Ed., 12, 673-687 (2001).
G. Liu, S.G. Eskin, and A.G. Mikos, “Integrin avb3 Is Involved in Stimulated Migration of Vascular Adventitial Fibroblasts by Basic Fibroblast Growth Factor but not Platelet-Derived Growth Factor,” J. Cell. Biochem., 83, 129-135 (2001).
W.T. Godbey and A.G. Mikos, “Recent Progress in Gene Delivery Using Non-Viral Transfer Complexes,” J. Controlled Release, 72, 115-125 (2001).
L. Lu, M.J. Yaszemski, and A.G. Mikos, “TGF-b1 Release from Biodegradable Polymer Microparticles: Its Effects on Marrow Stromal Osteoblast Function,” J. Bone Joint Surg., 83-A (Suppl. 1), 82-91 (2001).
S. Jo, H. Shin, A.K. Shung, J.P. Fisher, and A.G. Mikos, “Synthesis and Characterization of Oligo(Poly(Ethylene Glycol) Fumarate) Macromer,” Macromolecules, 34, 2839-2844 (2001).
A.S. Goldstein, T.M. Juarez, C.D. Helmke, M.C. Gustin, and A.G. Mikos, “Effect of Convection on Osteoblastic Cell Growth and Function in Biodegradable Polymer Foam Scaffolds,” Biomaterials, 22, 1279-1288 (2001).
S. Jo, H. Shin, and A.G. Mikos, “Modification of Oligo(Poly(Ethylene Glycol) Fumarate) Macromer with GRGD Peptide for the Preparation of Functionalized Polymer Networks,” Biomacromolecules, 2, 255-261 (2001).
W.T. Godbey, K.K. Wu, and A.G. Mikos, “Poly(Ethylenimine)-Mediated Gene Delivery Affects Endothelial Cell Function and Viability,” Biomaterials, 22, 471-480 (2001).
J.S. Blum, R.H. Li, A.G. Mikos, and M.A. Barry, “An Optimized Method for the Chemiluminescent Detection of Alkaline Phosphatase Levels during Osteodifferentiation by Bone Morphogenetic Protein 2,” J. Cell. Biochem., 80, 532-537 (2001).
L. Lu, K. Nyalakonda, L. Kam, R. Bizios, A. Göpferich, and A.G. Mikos, “Retinal Pigment Epithelial Cell Adhesion on Novel Micropatterned Surfaces Fabricated from Synthetic Biodegradable Polymers,” Biomaterials, 22, 291-297 (2001).
S. He, M.D. Timmer, M.J. Yaszemski, A.W. Yasko, P.S. Engel, and A.G. Mikos, “Synthesis of Biodegradable Poly(Propylene Fumarate) Networks with Poly(Propylene Fumarate)-Diacrylate Macromers as Crosslinking Agents and Characterization of Their Degradation Products,” Polymer, 42, 1251-1260 (2001).