Research Papers 1991-2000
2000
J.B. Oldham, L. Lu, X. Zhu, B.D. Porter, T.E. Hefferan, D.R. Larson, B.L. Currier, A.G. Mikos, and M.J. Yaszemski, “Biological Activity of rhBMP-2 Released from PLGA Microspheres,” J. Biomech. Eng., 122, 289-292 (2000).
B.D. Porter, J.B. Oldham, S.-L. He, M.E. Zobitz, R.G. Payne, K.N. An, B.L. Currier, A.G. Mikos, and M.J. Yaszemski, “Mechanical Properties of a Biodegradable Bone Regeneration Scaffold,” J. Biomech. Eng., 122, 286-288 (2000).
J.S. Temenoff and A.G. Mikos, “Injectable Biodegradable Materials for Orthopaedic Tissue Engineering,” Biomaterials, 21, 2405-2412 (2000).
S. He, M.J. Yaszemski, A.W. Yasko, P.S. Engel, and A.G. Mikos, “Injectable Biodegradable Polymer Composites Based on Poly(Propylene Fumarate) Crosslinked with Poly(Ethylene Glycol)-Dimethacrylate,” Biomaterials, 21, 2389-2394 (2000).
Q. Liu, E.L. Hedberg, Z. Liu, R. Bahulekar, R.K. Meszlenyi, and A.G. Mikos, “Preparation of Macroporous Poly(2-Hydroxyethyl Methacrylate) Hydrogels by Enhanced Phase Separation,” Biomaterials, 21, 2163-2169 (2000).
L. Lu, S.J. Peter, M.D. Lyman, H.-L. Lai, S.M. Leite, J.A. Tamada, S. Uyama, J.P. Vacanti, R. Langer, and A.G. Mikos, “In Vitro and In Vivo Degradation of Porous Poly(DL-Lactic-co-Glycolic Acid) Foams,” Biomaterials, 21, 1837-1845 (2000).
W.T. Godbey, M.A. Barry, P. Saggau, K.K. Wu, and A.G. Mikos, “Poly(Ethylenimine)-Mediated Transfection: A New Paradigm for Gene Delivery,” J. Biomed. Mater. Res., 51, 321-328 (2000).
S. Jo, P.S. Engel, and A.G. Mikos, “Synthesis of Poly(Ethylene Glycol)-Tethered Poly(Propylene Fumarate) and Its Modification with GRGD Peptide,” Polymer, 41, 7595-7604 (2000).
J.E. Babensee, L.V. McIntire, and A.G. Mikos, “Growth Factor Delivery for Tissue Engineering,” Pharm. Res., 17, 497-504 (2000)
J.S. Temenoff and A.G. Mikos, “Formation of Highly Porous Biodegradable Scaffolds for Tissue Engineering,” Electronic J. Biotechnol., 3 (2) (2000)
L. Lu, S.J. Peter, M.D. Lyman, H.-L. Lai, S.M. Leite, J.A. Tamada, J.P. Vacanti, R. Langer, and A.G. Mikos, “In Vitro Degradation of Porous Poly(L-Lactic Acid) Foams,” Biomaterials, 21, 1595-1605 (2000).
S.J. Peter, L. Lu, D.J. Kim, G.N. Stamatas, M.J. Miller, M.J. Yaszemski, and A.G. Mikos, “Effects of Transforming Growth Factor-b1 Released from Biodegradable Polymer Microparticles on Marrow Stromal Osteoblasts Cultured on Poly(Propylene Fumarate) Substrates,” J. Biomed. Mater. Res., 50, 452-462 (2000).
L. Lu, G.N. Stamatas, and A.G. Mikos, “Controlled Release of Transforming Growth Factor-b1 from Biodegradable Polymer Microparticles,” J. Biomed. Mater. Res., 50, 440-451 (2000).
S.J. Peter, L. Lu, D.J. Kim, and A.G. Mikos, “Marrow Stromal Osteoblast Function on a Poly(Propylene Fumarate)/b-Tricalcium Phosphate Biodegradable Orthopaedic Composite,” Biomaterials, 21, 1207-1213 (2000).
J.S. Temenoff and A.G. Mikos, “Tissue Engineering for Regeneration of Articular Cartilage,” Biomaterials, 21, 431-440 (2000).
1999
D.J. Mooney and A.G. Mikos, “Growing New Organs,” Scientific American Presents, 10 (3), 10-15 (1999).
L. Lu, L. Kam, M. Hasenbein, K. Nyalakonda, R. Bizios, A. Göpferich, J.F. Young, and A.G. Mikos, “Retinal Pigment Epithelial Cell Function on Substrates with Chemically Micropatterned Surfaces,” Biomaterials, 20, 2351-2361 (1999).
W.T. Godbey, K.K. Wu, and A.G. Mikos, “Tracking the Intracellular Path of Poly(Ethylenimine)/DNA Complexes for Gene Delivery,” Proceed. Natl. Acad. Sci. USA, 96, 5177-5181 (1999).
D.J. Mooney and A.G. Mikos, “Growing New Organs,” Scientific American, 280 (4), 60-65 (1999).
W.T. Godbey, K.K. Wu, and A.G. Mikos, “Poly(Ethylenimine) and Its Role in Gene Therapy,” J. Controlled Release, 60, 149-160 (1999).
W.T. Godbey, K.K. Wu, G.J. Hirasaki, and A.G. Mikos, “Improved Packing of Poly(Ethylenimine)/DNA Complexes Increases Transfection Efficiency,” Gene Therapy, 6, 1380-1388 (1999).
A.S. Goldstein, G. Zhu, G.E. Morris, R.K. Meszlenyi, and A.G. Mikos, “Effect of Osteoblastic Culture Conditions on the Structure of Poly(DL-Lactic-co-Glycolic Acid) Foam Scaffolds,” Tissue Eng., 5, 421-433 (1999).
D. Dean, N.S. Topham, C. Rimnac, A.G. Mikos, D.P. Goldberg, K. Jepsen, R. Redtfeldt, Q. Liu, D. Pennington, and R. Ratcheson, “Osseointegration of Preformed PMMA Craniofacial Prostheses Coated with Bone Marrow Impregnated Poly(DL-Lactic-co-Glycolic Acid) (PLGA) Foam,” Plast. Reconstr. Surg., 104, 705-712 (1999).
E. Behravesh, P.S. Engel, A.W. Yasko, and A.G. Mikos, “Synthetic Biodegradable Polymers for Orthopaedic Applications,” Clin. Orthop. Rel. Res., 367S, S118-S125 (1999).
R.C. Thomson, A.G. Mikos, E. Beahm, J.C. Lemon, W.C. Satterfield, T.B. Aufdemorte, and M.J. Miller, “Guided Tissue Fabrication from Periosteum Using Preformed Biodegradable Polymer Scaffolds,” Biomaterials, 20, 2007-2018 (1999).
A. Göpferich, S.J. Peter, A. Lucke, L. Lu, and A.G. Mikos, “Modulation of Marrow Stromal Cell Function Using Poly(D,L-Lactic Acid)-block-Poly(Ethylene Glycol)-Monomethyl Ether Surfaces,” J. Biomed. Mater. Res., 46, 390-398 (1999).
L. Lu, C.A. Garcia, and A.G. Mikos, “In Vitro Degradation of Thin Poly(DL-Lactic-co-Glycolic Acid) Films,” J. Biomed. Mater. Res., 46, 236-244 (1999).
G.R.D. Evans, K. Brandt, M.S. Widmer, L. Lu, R.K. Meszlenyi, P.K. Gupta, A.G. Mikos, J. Hodges, J. Williams, A. Gürlek, A. Nabawi, R. Lohman, and C.W. Patrick, Jr., “In Vivo Evaluation of Poly(L-Lactic Acid) Porous Conduits for Peripheral Nerve Regeneration,” Biomaterials, 20, 1109-1115 (1999).
L.J. Suggs and A.G. Mikos, “Development of Poly(Propylene Fumarate-co-Ethylene Glycol) as an Injectable Carrier for Endothelial Cells,” Cell Transplantation, 8, 345-350 (1999).
L.J. Suggs, M.S. Shive, C.A. Garcia, J.M. Anderson, and A.G. Mikos, “In Vitro Cytotoxicity and In Vivo Biocompatibility of Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels,” J. Biomed. Mater. Res., 46, 22-32 (1999).
W.T. Godbey, K.K. Wu, and A.G. Mikos, “Size Matters: Molecular Weight Affects the Efficiency of Poly(Ethylenimine) as a Gene Delivery Vehicle,” J. Biomed. Mater. Res., 45, 268-275 (1999).
L. Lu and A.G. Mikos, “Biodegradable Polymers for Cell Transplantation,” Science Medicine, 6 (1), 6-7 (1999).
S.J. Peter, L.J. Suggs, M.J. Yaszemski, P.S. Engel, and A.G. Mikos, “Synthesis of Poly(Propylene Fumarate) by Acylation of Propylene Glycol in the Presence of a Proton Scavenger,” J. Biomater. Sci., Polym. Ed., 10, 363-373 (1999).
L.J. Suggs, J.L. West, and A.G. Mikos, “Platelet Adhesion on a Bioresorbable Poly(Propylene Fumarate-co-Ethylene Glycol) Copolymer,” Biomaterials, 20, 683-690 (1999).
S.J. Peter, P. Kim, A.W. Yasko, M.J. Yaszemski, and A.G. Mikos, “Crosslinking Characteristics of an Injectable Poly(Propylene Fumarate)/b-Tricalcium Phosphate Paste and Mechanical Properties of the Crosslinked Composite for Use as a Biodegradable Bone Cement,” J. Biomed. Mater. Res., 44, 314-321 (1999).
1998
S.J. Peter, M.J. Miller, A.W. Yasko, M.J. Yaszemski, and A.G. Mikos, “Polymer Concepts in Tissue Engineering,” J. Biomed. Mater. Res. (Appl. Biomater.), 43, 422-427 (1998).
L.J. Suggs, R.S. Krishnan, C.A. Garcia, S.J. Peter, J.M. Anderson, and A.G. Mikos, “In Vitro and In Vivo Degradation of Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels,” J. Biomed. Mater. Res., 42, 312-320 (1998).
L. Lu, C.A. Garcia, and A.G. Mikos, “Retinal Pigment Epithelium Cell Culture on Thin Biodegradable Poly(DL-Lactic-co-Glycolic Acid) Films,” J. Biomater. Sci., Polym. Ed., 11, 1187-1205 (1998).
M.S. Widmer, P.K. Gupta, L. Lu, R.K. Meszlenyi, G.R.D. Evans, K. Brandt, T. Savel, A. Gurlek, C.W. Patrick, Jr., and A.G. Mikos, “Manufacture of Porous Biodegradable Polymer Conduits by an Extrusion Process for Guided Tissue Regeneration,” Biomaterials, 19, 1945-1955 (1998).
R.C. Thomson, M.J. Yaszemski, J.M. Powers, and A.G. Mikos, “Hydroxyapatite Fiber Reinforced Poly(a-Hydroxy Ester) Foams for Bone Regeneration,” Biomaterials, 19, 1935-1943 (1998).
J.E. Babensee, J.M. Anderson, L.V. McIntire, and A.G. Mikos, “Host Response to Tissue Engineered Devices,” Adv. Drug Deliv. Rev., 33, 111-139 (1998).
S.L. Ishaug-Riley, G.M. Crane-Kruger, M.J. Yaszemski, and A.G. Mikos, “Three-Dimensional Culture of Rat Calvarial Osteoblasts in Porous Biodegradable Polymers,” Biomaterials, 19, 1405-1412 (1998).
S.J. Peter, C.R. Liang, D.J. Kim, M.S. Widmer, and A.G. Mikos, “Osteoblastic Phenotype of Rat Marrow Stromal Cells Cultured in the Presence of Dexamethasone, b-Glycerolphosphate, and L-Ascorbic Acid,” J. Cell. Biochem., 71, 55-62 (1998).
S.J. Peter, S.T. Miller, G. Zhu, A.W. Yasko, and A.G. Mikos, “In Vivo Degradation of a Poly(Propylene Fumarate)/b-Tricalcium Phosphate Injectable Composite Scaffold,” J. Biomed. Mater. Res., 41, 1-7 (1998).
L.J. Suggs, E.Y. Kao, L.L. Palombo, R.S. Krishnan, M.S. Widmer, and A.G. Mikos, “Preparation and Characterization of Poly(Propylene Fumarate-co-Ethylene Glycol) Hydrogels,” J. Biomater. Sci., Polym. Ed., 9, 653-666 (1998).
M.C. Wake, P.D. Gerecht, L. Lu, and A.G. Mikos, “Effects of Biodegradable Polymer Particles on Rat Marrow-Derived Stromal Osteoblasts In Vitro,” Biomaterials, 19, 1255-1268 (1998).
1997
S.J. Peter, M.J. Yaszemski, L.J. Suggs, R.G. Payne, R. Langer, W.C. Hayes, M.R. Unroe, L.B. Alemany, P.S. Engel, and A.G. Mikos, “Characterization of Partially Saturated Poly(Propylene Fumarate) for Orthopaedic Application,” J. Biomater. Sci., Polym. Ed., 8, 893-904 (1997).
R.L. Cleek, K.C. Ting, S.G. Eskin, and A.G. Mikos, “Microparticles of Poly(DL-Lactic-co-Glycolic Acid)/Poly(Ethylene Glycol) Blends for Controlled Drug Delivery,” J. Controlled Release, 48, 259-268 (1997).
L.J. Suggs, R.G. Payne, M.J. Yaszemski, L.B. Alemany, and A.G. Mikos, “Synthesis and Characterization of a Block Copolymer Consisting of Poly(Propylene Fumarate) and Poly(Ethylene Glycol),” Macromolecules, 30, 4318-4323 (1997).
S.L. Ishaug, G.M. Crane, M.J. Miller, A.W. Yasko, M.J. Yaszemski, and A.G. Mikos, “Bone Formation by Three-Dimensional Stromal Osteoblast Culture in Biodegradable Polymer Scaffolds,” J. Biomed. Mater. Res., 36, 17-28 (1997).
S.L. Ishaug-Riley, G.M. Crane, A. Gurlek, M.J. Miller, M.J. Yaszemski, A.W. Yasko, and A.G. Mikos, “Ectopic Bone Formation by Marrow Stromal Osteoblast Transplantation Using Poly(DL-Lactic-co-Glycolic Acid) Foams Implanted into the Rat Mesentery,” J. Biomed. Mater. Res., 36, 1-8 (1997).
S.J. Peter, J.A. Nolley, M.S. Widmer, J.E. Merwin, M.J. Yaszemski, A.W. Yasko, P.S. Engel, and A.G. Mikos, “In Vitro Degradation of a Poly(Propylene Fumarate)/b-Tricalcium Phosphate Composite Orthopaedic Scaffold,” Tissue Eng., 3, 207-215 (1997).
R.L. Cleek, A.A. Rege, L.A. Denner, S.G. Eskin, and A.G. Mikos, “Inhibition of Smooth Muscle Cell Growth In Vitro by an Antisense Oligodeoxynucleotide Released from Poly(DL-Lactic-co-Glycolic Acid) Microparticles,” J. Biomed. Mater. Res., 35, 525-530 (1997).
L. Christenson, A.G. Mikos, D.F. Gibbons, and G.L. Picciolo, “Biomaterials for Tissue Engineering: Summary,” Tissue Eng., 3, 71-76 (1997).
K.B. Hellman, G.L. Picciolo, A.G. Mikos, and C.A. Vacanti, “Workshop on Tissue Engineering: Foreword,” Tissue Eng., 3, 65-66 (1997).
G.G. Giordano, R.C. Thomson, S.L. Ishaug, A.G. Mikos, S. Cumber, C.A. Garcia, and D. Lahiri-Munir, “Retinal Pigment Epithelium Cells Cultured on Synthetic Biodegradable Polymers,” J. Biomed. Mater. Res., 34, 87-93 (1997).
1996
C.R. Ruder, P. Dixon, A.G. Mikos, and M.J. Yaszemski, “The Growth and Phenotypic Expression of Human Osteoblasts,” Cytotechnology, 22, 263-267 (1996).
L. Lu and A.G. Mikos, “The Importance of New Processing Techniques in Tissue Engineering,” MRS Bulletin, 21, 28-32 (1996).
M.J. Yaszemski, R.G. Payne, W.C. Hayes, R. Langer, and A.G. Mikos, “The In Vitro Degradation of a Poly(Propylene Fumarate)-Based Composite Material,” Biomaterials, 17, 2127-2130 (1996).
M.C. Wake, P.K. Gupta, and A.G. Mikos, “Fabrication of Pliable Biodegradable Polymer Foams to Engineer Soft Tissues,” Cell Transplantation, 5, 465-473 (1996).
S.L. Ishaug, R.G. Payne, M.J. Yaszemski, T.B. Aufdemorte, R. Bizios, and A.G. Mikos, “Osteoblast Migration on Poly(a-Hydroxy Esters),” Biotechnol. Bioeng., 50, 443-451 (1996).
A.C. Jen, M.C. Wake, and A.G. Mikos, “Hydrogels for Cell Immobilization,” Biotechnol. Bioeng., 50, 357-364 (1996).
M.J. Miller, D.P. Goldberg, A.W. Yasko, J.C. Lemon, W.C. Satterfield, M.C. Wake, and A.G. Mikos, “Guided Bone Growth in Sheep: A Model for Tissue-Engineered Bone Flaps,” Tissue Eng., 2, 51-59 (1996).
R.C. Thomson, G.G. Giordano, J.H. Collier, S.L. Ishaug, A.G. Mikos, D. Lahiri-Munir, and C.A. Garcia, “Manufacture and Characterization of Poly(a-Hydroxy Ester) Thin Films as Temporary Substrates for Retinal Pigment Epithelium Cells,” Biomaterials, 17, 321-327 (1996).
M.J. Yaszemski, R.G. Payne, W.C. Hayes, R. Langer, and A.G. Mikos, “The Evolution of Bone Transplantation: Molecular, Cellular, and Tissue Strategies to Engineer Human Bone,” Biomaterials, 17, 175-185 (1996).
1995
G.M. Crane, S.L. Ishaug, and A.G. Mikos, “Bone Tissue Engineering,” Nature Medicine, 1, 1322-1324 (1995).
A.D. Ouellette, K.K. Wu, and A.G. Mikos, “Cardiovascular Gene Transfer,” Tissue Eng., 1, 311-322 (1995).
R.C. Thomson, M.C. Wake, M.J. Yaszemski, and A.G. Mikos, “Biodegradable Polymer Scaffolds to Regenerate Organs,” Adv. Polym. Sci., 122, 245-274 (1995).
R.C. Thomson, M.J. Yaszemski, J.M. Powers, and A.G. Mikos, “Fabrication of Biodegradable Polymer Scaffolds to Engineer Trabecular Bone,” J. Biomater. Sci., Polym. Ed., 7, 23-38 (1995).
M.C. Wake, A.G. Mikos, G. Sarakinos, J.P. Vacanti, and R. Langer, “Dynamics of Fibrovascular Tissue Growth in Hydrogel Foams,” Cell Transplantation, 4, 275-279 (1995).
H.A. von Recum, R.L. Cleek, S.G. Eskin, and A.G. Mikos, “Degradation of Polydispersed Poly(L-Lactic Acid) to Modulate Lactic Acid Release,” Biomaterials, 16, 441-447 (1995).
M.J. Yaszemski, R.G. Payne, W.C. Hayes, R. Langer, T.B. Aufdemorte, and A.G. Mikos, “The Ingrowth of New Bone Tissue and Initial Mechanical Properties of a Degrading Polymeric Composite Scaffold,” Tissue Eng., 1, 41-52 (1995).
1994
S.L. Ishaug, M.J. Yaszemski, R. Bizios, and A.G. Mikos, “Osteoblast Function on Synthetic Biodegradable Polymers,” J. Biomed. Mater. Res., 28, 1445-1453 (1994).
M.C. Wake, C.W. Patrick, Jr., and A.G. Mikos, “Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer Substrates,” Cell Transplantation, 3, 339-341 (1994).
A.G. Mikos, M.G. Papadaki, S. Kouvroukoglou, S.L. Ishaug, and R.C. Thomson, “Islet Transplantation to Create a Bioartificial Pancreas,” Biotechnol. Bioeng., 43, 673-677 (1994).
A.G. Mikos, A.J. Thorsen, L.A. Czerwonka, Y. Bao, R. Langer, D.N. Winslow, and J.P. Vacanti, “Preparation and Characterization of Poly(L-Lactic Acid) Foams,” Polymer, 35, 1068-1077 (1994).
A.G. Mikos, M.D. Lyman, L.E. Freed, and R. Langer, “Wetting of Poly(L-Lactic Acid) and Poly(DL-Lactic-co-Glycolic Acid) Foams for Tissue Culture,” Biomaterials, 15, 55-58 (1994).
1993
A.G. Mikos, G. Sarakinos, M.D. Lyman, D.E. Ingber, J.P. Vacanti, and R. Langer, “Prevascularization of Porous Biodegradable Polymers,” Biotechnol. Bioeng., 42, 716-723 (1993).
A.G. Mikos and N.A. Peppas, “Bioadhesive Phenomena in Controlled Release Systems,” Pharmakeftiki, 6, 1-10 (1993).
A.G. Mikos, G. Sarakinos, S.M. Leite, J.P. Vacanti, and R. Langer, “Laminated Three-Dimensional Biodegradable Foams for Use in Tissue Engineering,” Biomaterials, 14, 323-330 (1993).
H.L. Wald, G. Sarakinos, M.D. Lyman, A.G. Mikos, J.P. Vacanti, and R. Langer, “Cell Seeding in Porous Transplantation Devices,” Biomaterials, 14, 270-278 (1993).
A.G. Mikos, Y. Bao, L.G. Cima, D.E. Ingber, J.P. Vacanti, and R. Langer, “Preparation of Poly(Glycolic Acid) Bonded Fiber Structures for Cell Attachment and Transplantation,” J. Biomed. Mater. Res., 27, 183-189 (1993).
L.E. Freed, J.C. Marquis, A. Nohria, J. Emmanual, A.G. Mikos, and R. Langer, “Neocartilage Formation In Vitro and In Vivo Using Cells Cultured on Synthetic Biodegradable Polymers,” J. Biomed. Mater. Res., 27, 11-23 (1993).
1991
A.G. Mikos, E. Mathiowitz, R. Langer, and N.A. Peppas, “Interaction of Polymer Microspheres with Mucin Gels as a Means of Characterizing Polymer Retention on Mucus,” J. Colloid Interface Sci., 143, 366-373 (1991).
A.G. Mikos and C. Kiparissides, “Skin Formation in Heterogeneous Polymerization Reactions,” J. Membrane Sci., 59, 205-217 (1991).
A.G. Mikos and N.A. Peppas, “Brittle Fracture of Entangled Polymers,” J. Polym. Sci., Polym. Phys. Ed., 29, 837-841 (1991).