Research Papers 2021-Present
2024
C. Paindelli, V. Parietti, S. Barrios, P. Shepherd, T. Pan, W.-L. Wang, R.L. Satcher, C.J. Logothetis, N. Navone, M.T. Campbell, A.G. Mikos, and E. Dondossola, “Bone Mimetic Environments Support Engineering, Propagation, and Analysis of Therapeutic Response of Patient-Derived Cells, Ex Vivo and In Vivo,” Acta Biomaterialia, 178, 83-92 (2024).
S.M. Stanford, T.P. Nguyen, J. Chang, Z. Zhao, G.L. Hackman, E. Santelli, C.M. Sanders, M. Katiki, E. Dondossola, B.L. Brauer, M.A. Diaz, Y. Zhan, S.H. Ramsey, P.A. Watson, B. Sankaran, C. Paindelli, V. Parietti, A.G. Mikos, A. Lodi, A. Bagrodia, A. Elliott, R.R. McKay, R. Murali, S. Tiziani, A.N. Kettenbach, and N. Bottini, “Targeting Prostate Tumor Low-Molecular Weight Tyrosine Phosphatase for Oxidation-Sensitizing Therapy,” Science Adv., 10, eadg7887 (19pp) (2024).
N. Ahuja, K. Awad, S. Yang, H. Dong, A.G. Mikos, P. Aswath, S. Young, M. Brotto, and V. Varanasi, “SiONx Coating Regulates Mesenchymal Stem Cell Antioxidant Capacity via Nuclear Erythroid Factor 2 Activity under Toxic Oxidative Stress Condition,” Antioxidants, 13, 189 (20pp) (2024).
J.P. Fisher, A.G. Mikos, K. Schenke-Layland, H. Shin, J.A. Jansen, and X. Wang, “30 Years of Tissue Engineering,” Tissue Eng. Part A, 30, 3-4 (2024).
J.C. Chen, G. Bhave, F. Alrashdan, A. Dhuliyawalla, K.J. Hogan, A.G. Mikos, and J.T. Robinson, “Self-Rectifying Magnetoelectric Metamaterials for Remote Neural Stimulation and Motor Function Restoration,” Nature Mater., 23, 139-146 (2024).
2023
M. Bousnaki, A. Bakopoulou, I. Grivas, C. Bekiari, A. Pich, M. Rizk, K. Keklikoglou, E. Papachristou, G.C. Papadopoulos, A. Kritis, A.G. Mikos, and P. Koidis, “Managing Temporomandibular Joint Osteoarthritis by Dental Stem Cell Secretome,” Stem Cells Rev. Rep., 19, 2957-2979 (2023).
K.J. Hogan, H. Oztatli, M.R. Perez, S. Si, R. Umurhan, E. Jui, Z. Wang, E.Y. Jiang, S.R. Han, M. Diba, K.J. Grande-Allen, B. Garipcan, and A.G. Mikos, “Development of Photoreactive Demineralized Bone Matrix 3D Printing Colloidal Inks for Bone Tissue Engineering,” Regener. Biomater., 10, rbad090 (14pp) (2023).
K.J. Hogan, M.R. Perez, H. Oztatli, S. Si, Z. Wang, E.Y. Jiang, M. Diba, B. Garipcan, and A.G. Mikos, “Development of 3D-Printing Composite Inks Based on Photoreactive Cartilage Extracellular Matrix and Gelatin Nanoparticles,” Bioprinting, 36, e00317 (15pp) (2023).
E.Y. Jiang, S.T. Desroches, and A.G. Mikos, “Particle Carriers for Controlled Release of Peptides,” J. Controlled Release, 360, 953-968 (2023).
A.G. Mikos, “3D Micropattern Force Regulates Stem Cell Function,” Natl. Sci. Rev., 10, nwad198 (2pp) (2023).
K.J. Hogan, M.R. Perez, and A.G. Mikos, “Extracellular Matrix Component-Derived Nanoparticles for Drug Delivery and Tissue Engineering,” J. Controlled Release, 360, 888-912 (2023).
B. van Oirschot, J.J.J.P. van den Beucken, A.G. Mikos, and J.A. Jansen, “Lateral Bone Augmentation Using a Three-Dimensional-Printed Polymeric Chamber to Compare Biomaterials,” Tissue Eng. Part C: Methods, 29, 287-297 (2023).
Q. Liu, I. Lodoso-Torrecilla, R. Klein Gunnewiek, H.R. Harhangi, A.G. Mikos, L. van Niftrik, J.A. Jansen, L. Chen, and J.J.J.P. van den Beucken, “Tunable Calcium Phosphate Cement Formulations for Predictable Local Release of Doxycycline,” Materialia, 28, 101769 (11pp) (2023).
R. Wang, M. Wang, R. Jin, Y. Wang, M. Yi, Q. Li, J. Li, K. Zhang, C. Sun, Y. Nie, C. Huang, A.G. Mikos, and X. Zhang, “High Strength Titanium with Fibrous Grain for Advanced Bone Regeneration,” Adv. Science, 10, 2207698 (11pp) (2023).
L.K. Chim, I.L. Williams, C.J. Bashor, and A.G. Mikos, “Tumor-Associated Macrophages Induce Inflammation and Drug Resistance in a Mechanically Tunable Engineered Model of Osteosarcoma,” Biomaterials, 296, 122076 (12pp) (2023).
B. van Oirschot, A.G. Mikos, Q. Liu, J.J.J.P. van den Beucken, and J.A. Jansen, “Fast Degradable Calcium Phosphate Cement for Maxillofacial Bone Regeneration,” Tissue Eng. Part A, 29, 161-171 (2023).
Y. Zhao, J. Zheng, Y. Xiong, H. Wang, S. Yang, X. Sun, L. Zhao, A.G. Mikos, and X. Wang, “Hierarchically Engineered Artificial Lamellar Bone with High Strength and Toughness,” Small Struct., 4, 2200256 (9pp) (2023).
E. Watson, H.A. Pearce, K.J. Hogan, N.W.M. van Dijk, M.M. Smoak, S. Barrios, B.T. Smith, A.M. Tatara, T.C. Woernley, J. Shum, C.B. Pearl, J.C. Melville, T. Ho, I.A. Hanna, N. Demian, J.J.J.P. van den Beucken, J.A. Jansen, M.E. Wong, and A.G. Mikos, “Repair of Complex Ovine Segmental Mandibulectomy Utilizing Tissue Engineered Bony Flaps,” PLoS One, 18, e0280481 (19pp) (2023).
E. Watson and A.G. Mikos, “Advances in In Vitro and In Vivo Bioreactor-Based Bone Generation for Craniofacial Tissue Engineering,” BME Frontiers, 4, 0004 (14pp) (2023).
K. Loukelis, Z.A. Ηelal, A.G. Mikos, and M. Chatzinikolaidou, “Nanocomposite Bioprinting for Tissue Engineering Applications,” Gels, 9, 103 (30pp) (2023).
M.L. Bedell, Z. Wang, K.J. Hogan, A.L. Torres, H.A. Pearce, L.K. Chim, K.J. Grande-Allen, and A.G. Mikos, “The Effect of Multi-Material Architecture on the Ex Vivo Osteochondral Integration of Bioprinted Constructs,” Acta Biomaterialia, 155, 99-112 (2023).
H.A. Pearce, J.W.R. Swain, L.H. Victor, K.J. Hogan, E.Y. Jiang, M.L. Bedell, A.M. Navara, A. Farsheed, Y.S. Kim, J.L. Guo, J.D. Hartgerink, K.J. Grande-Allen, and A.G. Mikos, “Thermogelling Hydrogel Charge and Lower Critical Solution Temperature Influence Cellular Infiltration and Tissue Integration in an Ex Vivo Cartilage Explant Model,” J. Biomed. Mater. Res. Part A, 111, 15-34 (2023).
B. Mahadik, R. Margolis, S. McLoughlin, A. Melchiorri, S.J. Lee, J. Yoo, A. Atala, A.G. Mikos, and J.P. Fisher, “An Open-Source Bioink Database for Microextrusion 3D Printing,” Biofabrication, 15, 015008 (11pp) (2023).
2022
M. Parlani, M.L. Bedell, A.G. Mikos, P. Friedl, and E. Dondossola, “Dissecting the Recruitment and Self-Organization of aSMA-Positive Fibroblasts in the Foreign Body Response,” Science Adv., 8, eadd0014 (14pp) (2022).
W. Zhao, J. Yang, Y. Kang, K. Hu, M. Jiao, B. Zhao, Y. Jiang, C. Liu, F. Ding, B. Yuan, B. Ma, K. Zhang, A.G. Mikos, and X. Zhang, “Animal Models of Rotator Cuff Injury and Repair: A Systematic Review,” Tissue Eng. Part B: Reviews, 28, 1258-1273 (2022).
B. Yuan, Y. Zhang, R. Zhao, H. Lin, X. Yang, X. Zhu, K. Zhang, A.G. Mikos, and X. Zhang, “A Unique Biomimetic Modification Endows Polyetherketoneketone Scaffold with Osteoinductivity by Activating cAMP/PKA Signaling Pathway,” Science Adv., 8, eabq7116 (12pp) (2022).
H.A. Pearce and A.G. Mikos, “Thermogelling Materials and Their Important Role in Biomedical Engineering Applications,” Curr. Opin. Biomed. Eng., 24, 100412 (7pp) (2022).
M.L. Bedell, A.L. Torres, K.J. Hogan, Z. Wang, B. Wang, A.J. Melchiorri, K.J. Grande-Allen, and A.G. Mikos, “Human Gelatin-Based Composite Hydrogels for Osteochondral Tissue Engineering and their Adaptation into Bioinks for Extrusion, Inkjet, and Digital Light Processing Bioprinting,” Biofabrication, 14, 045012 (26pp) (2022).
P. Zhao, W. Liu, J. Tian, X. Shi, X. Gu, and A.G. Mikos, “Tissue Engineering and Regulatory Science,”
Engineering, 13,9-12 (2022)
C. Paindelli, S. Casarin, F. Wang, L. Diaz-Gomez, J. Zhang, A.G. Mikos, C.J. Logothetis, P. Friedl, and E. Dondossola, “Enhancing 223Ra Treatment Efficacy by Anti-beta1 Integrin Targeting,” J. Nucl. Med., 63, 1039-1045 (2022).
J. Bai, A.M. Navara, L. Zhao, Y. Song, X. Yang, X. Lian, and A.G. Mikos, “Harnessing Electrostatic Interactions for Enhanced Printability of Alginate-Based Bioinks,” Bioprinting, 27, e00215 (11pp) (2022).
X. Song, Z. Tang, W. Liu, K. Chen, J. Liang, B. Yuan, H. Lin, X. Zhu, Y. Fan, X. Shi, P. Zhao, L. Yang, K. Zhang, A.G. Mikos, and X. Zhang, “Biomaterials and Regulatory Science,” J. Mater. Sci. Technol., 128, 221-227 (2022).
B.A.J.A. van Oirschot, E.J.W. Geven, A.G. Mikos, J.J.J.P. van den Beucken, and J.A. Jansen, “A Mini-Pig Mandibular Defect Model for Evaluation of Craniomaxillofacial Bone Regeneration,” Tissue Eng. Part C: Methods, 28, 193-201 (2022).
K. Zhang, B. Ma, K. Hu, B. Yuan, X. Sun, X. Song, Z. Tang, H. Lin, X. Zhu, Y. Zheng, A.J. Garcia, A.G. Mikos, J.M. Anderson, and X. Zhang, “Evidence-Based Biomaterials Research,” Bioact. Mater., 15, 495-503 (2022).
J. Zhu, S. Yang, Y. Qi, Z. Gong, H. Zhang, K. Liang, P. Shen, Y.-Y. Huang, Z. Zhang, W. Ye, L. Yue, S. Fan, S. Shen, A.G. Mikos, X. Wang, and X. Fang, “Stem Cell-Homing Hydrogel-Based miR-29b-5p Delivery Promotes Cartilage Regeneration by Suppressing Senescence in an Osteoarthritis Rat Model,” Science Adv., 8, eabk0011 (16pp) (2022).
K.J. Hogan, M.M. Smoak, G.L. Koons, M.R. Perez, M.L. Bedell, E.Y. Jiang, S. Young, and A.G. Mikos, “Bioinspired Electrospun Decellularized Extracellular Matrix Scaffolds Promote Muscle Regeneration in a Rat Skeletal Muscle Defect Model,” J. Biomed. Mater. Res. Part A, 110, 1090-1100 (2022).
E.R. Molina, L.K. Chim, S.-E. Lamhamedi-Cherradi, S. Mohiuddin, D. McCall, B. Cuglievan, S. Krishnan, R.W. Porter, D.R. Ingram, W.-L. Wang, A.J. Lazar, D.W. Scott, D.D. Truong, N.C. Daw, J.A. Ludwig, and A.G. Mikos, “Correlation of Nuclear pIGF-1R/IGF-1R and YAP/TAZ in a Tissue Microarray with Outcomes in Osteosarcoma Patients,” Oncotarget, 13, 521-533 (2022).
A.M. Navara, Y.S. Kim, Y. Xu, C.L. Crafton, M. Diba, J.L. Guo, and A.G. Mikos, “A Dual-Gelling Poly(N-isopropylacrylamide)-Based Ink and Thermoreversible Poloxamer Support Bath for High-Resolution Bioprinting,” Bioact. Mater., 14, 302-312 (2022).
M. Sarti, M. Parlani, L. Diaz-Gomez, A.G. Mikos, P. Cerveri, S. Casarin, and E. Dondossola, “Deep Learning for Automated Analysis of Cellular and Extracellular Components of the Foreign Body Response in Multiphoton Microscopy Images,” Front. Bioeng. Biotechnol., 9, 797555 (15pp) (2022).
Y. Chai, H. Zhao, S. Yang, X. Gao, Z. Cao, J. Lu, Q. Sun, W. Liu, Z. Zhang, J. Yang, X. Wang, T. Chen, X. Kong, A.G. Mikos, X. Zhang, Y. Zhang, and X. Wang, “Structural Alignment Guides Oriented Migration and Differentiation of Endogenous Neural Stem Cells for Neurogenesis in Brain Injury Treatment,” Biomaterials, 280, 121310 (11pp) (2022).
2021
H.A. Pearce and A.G. Mikos, “Machine Learning and Medical Devices: The Next Step for Tissue Engineering,” Engineering, 7, 1704-1706 (2021).
H.A. Pearce, E.Y. Jiang, J.W.R. Swain, A.M. Navara, J.L. Guo, Y.S. Kim, A. Woehr, J.D. Hartgerink, and A.G. Mikos, “Evaluating the Physicochemical Effects of Conjugating Peptides into Thermogelling Hydrogels for Regenerative Biomaterials Applications,” Regener. Biomater., 8, rbab073 (13pp) (2021).
S.-E. Lamhamedi-Cherradi, S. Mohiuddin, D.K. Mishra, S. Krishnan, A. Ruiz Velasco, A.M. Vetter, K. Pence, D. McCall, D.D. Truong, B. Cuglievan, B.A. Menegaz, B. Utama, N.C. Daw, E.R. Molina, R.J. Zielinski, J.A. Livingston, R. Gorlick, A.G. Mikos, M.P. Kim, and J.A. Ludwig, “Transcriptional Activators YAP/TAZ and AXL Orchestrate Dedifferentiation, Cell Fate, and Metastasis in Human Osteosarcoma,” Cancer Gene Ther., 28, 1325-1338 (2021).
B. Melendez, S. Shah, Y. Jiang, J. Dottino, E. Watson, H. Pearce, M. Borthwick, R.E. Schmandt, Q. Zhang, K. Cumpian, J. Celestino, B. Fellman, Y. Yuan, K.H. Lu, A.G. Mikos, and M.S. Yates, “Novel Polymer-Based System for Intrauterine Delivery of Everolimus for Anti-Cancer Applications,” J. Controlled Release, 339, 521-530 (2021).
T. Bello, C. Paindelli, L.A. Diaz-Gomez, A. Melchiorri, A.G. Mikos, P.S. Nelson, E. Dondossola, and T.S. Gujral, “Computational Modeling Identifies Multitargeted Kinase Inhibitors as Effective Therapies for Metastatic, Castration-Resistant Prostate Cancer,” Proceed. Natl. Acad. Sci. USA, 118, e2103623118 (11pp) (2021).
G.L. Koons, P.D. Kontoyiannis, M. Diba, L.K. Chim, D.W. Scott, and A.G. Mikos, “Effect of 3D Printing Temperature on Bioactivity of Bone Morphogenetic Protein-2 Released from Polymeric Constructs,” Ann. Biomed. Eng., 49, 2114-2125 (2021).
Y.S. Kim, S.M. Mehta, J.L. Guo, H.A. Pearce, B.T. Smith, E. Watson, G.L. Koons, A.M. Navara, J. Lam, K.J. Grande-Allen, and A.G. Mikos, “Evaluation of Tissue Integration of Injectable, Cell-Laden Hydrogels of Cocultures of Mesenchymal Stem Cells and Articular Chondrocytes with an Ex Vivo Cartilage Explant Model,” Biotechnol. Bioeng., 118, 2958-2966 (2021).
H.A. Pearce, Y.S. Kim, E. Watson, K. Bahrami, M.M. Smoak, E.Y. Jiang, M. Elder, T. Shannon, and A.G. Mikos, “Development of a Modular, Biocompatible Thiolated Gelatin Microparticle Platform for Drug Delivery and Tissue Engineering Applications,” Regener. Biomater., 8, rbab012 (12pp) (2021).
S.M. Bittner, H.A. Pearce, K.J. Hogan, M.M. Smoak, J.L. Guo, A.J. Melchiorri, D.W. Scott, and A.G. Mikos, “Swelling Behaviors of 3D Printed Hydrogel and Hydrogel-Microcarrier Composite Scaffolds,” Tissue Eng. Part A, 27, 665-678 (2021).
J.L. Guo, Y.S. Kim, G.L. Koons, J. Lam, A.M. Navara, S. Barrios, V.Y. Xie, E. Watson, B.T. Smith, H.A. Pearce, E.A. Orchard, J.J.J.P. van den Beucken, J.A. Jansen, M.E. Wong, and A.G. Mikos, “Bilayered, Peptide-Biofunctionalized Hydrogels for In Vivo Osteochondral Tissue Repair,” Acta Biomaterialia, 128, 120-129 (2021).
M. Diba, G.L. Koons, M.L. Bedell, and A.G. Mikos, “3D Printed Colloidal Biomaterials Based on Photo-Reactive Gelatin Nanoparticles,” Biomaterials, 274, 120871 (16pp) (2021).
M.M. Smoak, K.J. Hogan, K.J. Grande-Allen, and A.G. Mikos, “Bioinspired Electrospun dECM Scaffolds Guide Cell Growth and Control the Formation of Myotubes,” Science Adv., 7, eabg4123 (12pp) (2021).
S. Peper, T. Vo, N. Ahuja, K. Awad, A.G. Mikos, and V. Varanasi, “Bioprinted Nanocomposite Hydrogels: A Proposed Approach to Functional Restoration of Skeletal Muscle and Vascular Tissue Following Volumetric Muscle Loss,” Curr. Opin. Pharmacol., 58, 35-43 (2021).
J.L. Guo, L. Diaz-Gomez, V.Y. Xie, S.M. Bittner, E.Y. Jiang, B. Wang, and A.G. Mikos, “Three-Dimensional Printing of Click Functionalized, Peptide Patterned Scaffolds for Osteochondral Tissue Engineering,” Bioprinting, 22, e00136 (9pp) (2021).
S. Wurster, O.E. Ruiz, K.M. Samms, A.M. Tatara, N.D. Albert, P.H. Kahan, A.T. Nguyen, A.G. Mikos, D.P. Kontoyiannis, and G.T. Eisenhoffer, “EGF-Mediated Suppression of Cell Extrusion during Mucosal Damage Attenuates Opportunistic Fungal Invasion,” Cell Reports, 34, 108896 (12pp) (2021).
Y.S. Kim and A.G. Mikos, “Emerging Strategies in Reprogramming and Enhancing the Fate of Mesenchymal Stem Cells for Bone and Cartilage Tissue Engineering,” J. Controlled Release, 330, 565-574 (2021).